Diagnosis Based on Detection of CXCL10 in Urine as Biomarker for The Determining Diagnosis of Active Lung Tuberculosis

Mertaniasih, Ni Made; Ananda, I Gede Yogi Prema; Soedarsono, Soedarsono; Kusumaningrum, Deby

doi:10.20473/ijtid.v9i1.22160

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Pulmonary tuberculosis is the infectious and the most common form of tuberculosis, occurring in over 80% of cases. 19 A study found that patients who had recently been infected with M tuberculosis caused functional fatigue and reduced CD4+ T cells. This correlation between M. tuberculosis infection and CD4+ T cells which underlies that tuberculosis treatment will correlate with an increase in CD4+ T cells counts.…”

Section: Discussionmentioning

confidence: 99%

A patient with CD4+ T cells deficiency and HIV negative with pulmonary tuberculosis, tuberculous pleuritis and meningitis tuberculosis

Triwicaksana¹,

Rusli²,

Arfijanto³

et al. 2022

Bali Med J.

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Background: CD4+ T cells deficiency generally occurs in human immunodeficiency virus (HIV) patients, leading to some infections such as pulmonary and extrapulmonary tuberculosis. A rare case of decreased CD4+ T cells is idiopathic CD4+ T cell lymphocytopenia, a rare and unexplained immunodeficiency syndrome with no evidence of HIV infection. In this case report, we are reporting a patient with CD4+ T cells deficiency, pulmonary tuberculosis, pleuritis tuberculosis, and meningitis with HIV test negative. Case Presentation: A 58-year-old male was referred to the Emergency Department of Dr. Soetomo General Hospital with a gradual decrease of consciousness following six days of hospitalization at a private hospital. During hospitalization, one liter of fluid was evacuated from the right lung and analyzed, revealing tuberculosis infection. History of diabetes, hypertension, stroke, hepatitis, and cardiovascular disease was denied. The patient also never had chemotherapy or radiation treatment. Based on history taking, physical examination, and laboratory results, this patient has been diagnosed new case of pulmonary tuberculosis with deficiency CD4+ T cells and altered consciousness et causes meningitis tuberculosis with pleurisy tuberculosis. After 32 days of hospitalization with anti-mycobacterium therapy, the patient was improved and was discharged. Conclusion: This case highlights the challenges of having the definitive cause of CD4+ T cells deficiency either active tuberculosis infection or idiopathic CD4+ lymphocytopenia. Therefore, serial analyses of CD4+ T cells are advised on the patient during the treatment with anti-tuberculosis drug.

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Section: Discussionmentioning

confidence: 99%

A patient with CD4+ T cells deficiency and HIV negative with pulmonary tuberculosis, tuberculous pleuritis and meningitis tuberculosis

Triwicaksana¹,

Rusli²,

Arfijanto³

et al. 2022

Bali Med J.

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“…Preliminary studies has been showed that CXCL10 is associated with a variety of human diseases including infectious diseases, chronic inflammatory disease, and immune dysfunctions ( Mertaniasih et al, 2021 ). This makes CXCL10 currently considered as a diagnostic tool for leprosy, because of its role in their pathogenesis and easily accessible detection method ( Pujiastuti, Agusni & Rahmadewi, 2017 ; Medeiros et al, 2015 ; Mertaniasih et al, 2021 ). Identifying CXCL10 can be convenient through easily accessible lateral flow assays, rendering it a feasible indicator for detecting leprosy ( Van Hooij et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The role of CXCL10 as a biomarker for immunological response among patients with leprosy: a systematic literature review

Prakoeswa,

Haningtyas,

Dewi

et al. 2024

PeerJ

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Introduction Involvement of a chemokine known as C-X-C motif chemokine ligand 10 or CXCL10 in the immunopathology of leprosy has emerged as a possible immunological marker for leprosy diagnosis and needed to be investigate further. The purpose of this systematic review is to assess CXCL10’s potential utility as a leprosy diagnostic tool and evaluation of therapy. Methods This systematic review is based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. A thorough search was carried out to find relevant studies only in English and limited in humans published up until September 2023 using PubMed, Scopus, Science Direct, and Wiley Online Library database with keywords based on medical subject headings (MeSH) and no exclusion criteria. The Newcastle-Ottawa Scale (NOS) was utilized for quality assessment, while the Risk of Bias Assessment tool for Non-randomized Studies (RoBANS) was utilized for assessing the risk of bias. Additionally, a narrative synthesis was conducted to provide a comprehensive review of the results. Results We collected a total of 115 studies using defined keywords and 82 studies were eliminated after titles and abstracts were screened. We assessed the eligibility of the remaining 26 reports in full text and excluded four studies due to inappropriate study design and two studies with incomplete outcome data. There were twenty included studies in total with total of 2.525 samples. The included studies received NOS quality evaluation scores ranging from 6 to 8. The majority of items in the risk bias assessment, using RoBANS, across all included studies yielded low scores. However, certain items related to the selection of participants and confounding variables showed variations. Most of studies indicate that CXCL10 may be a helpful immunological marker for leprosy diagnosis, particularly in leprosy reactions as stated in seven studies. The results are better when paired with other immunological markers. Its effectiveness in field-friendly diagnostic tools makes it one of the potential biomarkers used in diagnosing leprosy patients. Additionally, CXCL10 may be utilized to assess the efficacy of multidrug therapy (MDT) in leprosy patients as stated in three studies. Conclusion The results presented in this systematic review supports the importance of CXCL10 in leprosy diagnosis, particularly in leprosy responses and in tracking the efficacy of MDT therapy. Using CXCL10 in clinical settings might help with leprosy early diagnosis. Yet the findings are heterogenous, thus more investigation is required to determine the roles of CXCL10 in leprosy while taking into account for additional confounding variables.

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Diagnosis Based on Detection of CXCL10 in Urine as Biomarker for The Determining Diagnosis of Active Lung Tuberculosis

Cited by 2 publications

References 25 publications

A patient with CD4+ T cells deficiency and HIV negative with pulmonary tuberculosis, tuberculous pleuritis and meningitis tuberculosis

A patient with CD4+ T cells deficiency and HIV negative with pulmonary tuberculosis, tuberculous pleuritis and meningitis tuberculosis

The role of CXCL10 as a biomarker for immunological response among patients with leprosy: a systematic literature review

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