Diagnosis and Treatment of Vascular Surgery Related Infection

Yong-gan, Zhang; Song, Yan; Miao, Chao-Feng; Zhang, Chuang; Chen, Ningheng

doi:10.2174/1874120701509010250

Cited by 9 publications

(15 citation statements)

References 16 publications

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“…Infections in artificial veins can sometimes lead to its replacement 21 or even serious organ damage 20 . The epidermis is the primary source of bacteria.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Noninvasive thrombectomy of graft by nano-magnetic ablating particles

Moghanizadeh

Ashrafizadeh

Varshosaz

et al. 2021

Sci Rep

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Artificial vascular treatment is an emerging interdisciplinary subject of medicine. Although the use of artificial vessels has led to many successful advancements, blood clotting remains a major challenge, especially in terms of mural clots created along the vessel wall that do not completely block the vessel. The main objective of this study is to present a method for declotting artificial vessels. This research introduces a novel thrombectomy technique in artificial vessels by employing nano-magnetic particles under a rotating magnetic field to remove mural clots in artificial vessels. A mathematical model describes the relationship between process parameters. In vitro tests confirm the feasibility of nano-magnetic thrombectomy in cleaning and declotting artificial vessels. The results show that the clot fragments are nano-sized, which eliminates the risk of distal emboli as a concern of using current atherectomy techniques. Meanwhile, no damage to the artificial vessels is observed. The results show that the frequency of rotating the magnetic field has the greatest effect on clot removal. The conceptual principles stated in this study also have the potential to be used in other vascular depositions, such as the accumulation of lipids, and calcification atherosclerosis.

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“…Infections in artificial veins can sometimes lead to its replacement 21 or even serious organ damage 20 . The epidermis is the primary source of bacteria.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Noninvasive thrombectomy of graft by nano-magnetic ablating particles

Moghanizadeh

Ashrafizadeh

Varshosaz

et al. 2021

Sci Rep

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“…Although a major source for vascular surgery infections is by bacteria transference with vascular graft tissue, 44 patients undergoing non-implant surgery -as with most surgical procedures -are also prone to infection via the surgical procedure. In a recent (non-randomised comparative) study, the use of Leukomed Sorbact was shown to be an effective treatment in this indication.…”

Section: Vascular Surgerymentioning

confidence: 99%

Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review

Chadwick

Ousey

2019

J Wound Care

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The aim of this review was to present the clinical data on the use of the family of bacterial-binding dressings (Sorbact; dialkylcarbamoyl chloride-coated) in the treatment of a variety of acute and chronic wounds. The findings are discussed in terms of the effectiveness of the bacterial-binding dressings on bacterial bioburden reduction, infection prevention, initiation/progression of wound healing and cost-effectiveness. The evidence in support of the bacterial-binding dressings is strongest in the area of infection prevention in surgical wounds, with several controlled trials showing the prophylactic benefit of the dressing in these wounds. Wound bioburden management in chronic wounds is supported by a number of clinical studies. In total, 29 published clinical studies (with a total of 4044 patients) were included in this review.

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“…Periprosthetic joint infections (PJIs) can be a devastating complication resulting from some arthroplasties and can involve infection of both the soft tissue surrounding the prosthetic implant as well as the inside of the bone in severe cases [ 1 ]. To mitigate the development of and to treat PJIs, antibiotic-laden poly(methyl methacrylate) (PMMA) bone cement is often utilized where it is either directly implanted in the bone (i.e., arthroplasty fixation) or in the form of beads that are embedded into the surrounding infected soft tissue to locally deliver antibiotics [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. When antibiotic-laden PMMA is directly implanted into the bone, there is a unique challenge to administer additional antibiotic doses into the implanted PMMA if the infection is prolonged.…”

Section: Introductionmentioning

confidence: 99%

Poly(methyl methacrylate) Bone Cement Composite Can Be Refilled with Antibiotics after Implantation in Femur or Soft Tissue

Cyphert

Zhang

Marques

et al. 2021

JFB

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While periprosthetic joint infections (PJIs) result in a small percentage of patients following arthroplasties, they are challenging to treat if they spread into bone and soft tissue. Treatment involves delivering antibiotics using poly(methyl methacrylate) (PMMA) bone cement. However, antibiotic release is insufficient for prolonged infections. Previous work demonstrated efficacy of incorporating insoluble cyclodextrin (CD) microparticles into PMMA to improve antibiotic release and allow for post-implantation drug refilling to occur in a tissue-mimicking model. To simulate how antibiotic refilling may be possible in more physiologically relevant models, this work investigated development of bone and muscle refilling models. The bone refilling model involved embedding PMMA-CD into rabbit femur and administering antibiotic via intraosseous infusion. Muscle tissue refilling model involved implanting PMMA-CD beads in bovine muscle tissue and administering antibiotic via tissue injection. Duration of antimicrobial activity of refilled PMMA-CD was evaluated. PMMA-CD composite in bone and muscle tissue models was capable of being refilled with antibiotics and resulted in prolonged antimicrobial activity. PMMA-CD provided sustained and on-demand antimicrobial activity without removal of implant if infection develops. Intraosseous infusion appeared to be a viable technique to enable refilling of PMMA-CD after implantation in bone, reporting for the first time the ability to refill PMMA in bone.

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Diagnosis and Treatment of Vascular Surgery Related Infection

Cited by 9 publications

References 16 publications

RETRACTED ARTICLE: Noninvasive thrombectomy of graft by nano-magnetic ablating particles

RETRACTED ARTICLE: Noninvasive thrombectomy of graft by nano-magnetic ablating particles

Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review

Poly(methyl methacrylate) Bone Cement Composite Can Be Refilled with Antibiotics after Implantation in Femur or Soft Tissue

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