Diagnosis and Treatment of the Extraesophageal Manifestations of Gastroesophageal Reflux Disease

Sidwa, Feroze; Moore, Alessandra L.; Alligood, Elaine; Fisichella, P. Marco

doi:10.1007/978-3-319-46885-3_5

Cited by 4 publications

(6 citation statements)

References 56 publications

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“…If acidic reflux is excluded, the therapeutic options are much more narrow: In these cases, no effective medical therapy is available, and a purely surgical approach is not recommended based on current experience [40] since no high-quality studies, particularly randomized trials, have been published so far [41]. It is not surprising that patients reporting concomitant typical reflux symptoms are more likely to benefit from antireflux surgery compared to those in whom typical GERD symptoms are lacking [42], placing a question mark over the surgical option ( fig. 3).…”

Section: Extraesophageal Manifestationsmentioning

confidence: 99%

Medical Therapy of Gastroesophageal Reflux Disease Beyond Proton Pump Inhibitors: Where Are We Heading

Koop

2018

Visc Med

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Proton pump inhibitors (PPI) have greatly improved the treatment of gastroesophageal reflux disease. However, recent investigations have revealed that reflux symptoms persist in a substantial number of patients. Therefore, treatment strategies beyond PPI are urgently required. One such strategy may involve more reliable acid suppression, e.g., with new acid inhibitory drugs. Furthermore, the rapid appearance of an acidic compartment in the proximal stomach after a meal, which is largely responsible for postprandial heartburn, requires a specific kind of therapy in addition to PPI which still needs to be established. Pharmacological augmentation of the lower esophageal sphincter may represent another approach to diminish reflux, but the clinical efficacy of compounds tested so far is limited. Altered e-sophageal perception represents a major component involved in the generation of reflux symptoms, particularly in non-erosive reflux disease, but effective pharmacological intervention is largely lacking. Presumed reflux-induced respiratory symptoms (cough, laryngitis, etc.) in the absence of typical esophageal symptoms (e.g., heartburn) remain a hot topic, but recent research points towards a hypersensitivity syndrome and only a minor role of gastroesophageal reflux. Treatment options for this condition are still pending.

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Section: Extraesophageal Manifestationsmentioning

confidence: 99%

Medical Therapy of Gastroesophageal Reflux Disease Beyond Proton Pump Inhibitors: Where Are We Heading

Koop

2018

Visc Med

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“…Identifying dogs with AeroD is important as failing to treat occult GI disease may, as in people, allow for progression of disease and contribute to patient morbidity and mortality. (5,108,117,140,162,163) Based on our study, evaluation of alimentary tract disorders using VFSS should be considered as a part of the clinical evaluation of coughing dogs.…”

Section: Discussionmentioning

confidence: 95%

“…Concurrent nasal disease (sneezing, nasal discharge and reverse sneezing) were also encountered, paralleling human studies where extra-esophageal reflux (EER) results in nasopharyngeal as signs as well as cough. (4,117,164) Four dogs had neurologic deficits on physical examination. Though this was identified in a relatively small number of patients, this study and others support a relationship between neurologic dysfunction, dysphagia, and respiratory disease.…”

Section: Discussionmentioning

confidence: 99%

“…(107)(108)(109)(110)(111) Adjunctive diagnostic and monitoring strategies for GER and EER in veterinary medicine incorporate a combination of client surveys, treatment trials with proton pump inhibitors (PPIs), esophagoscopy, and rarely esophageal manometry and ambulatory pH probes. (19,(112)(113)(114)(115)(116)(117)(118)(119) However, these have significant limitations. Client reporting is inherently prone to bias due to variable client vigilance, and a failure to recognize episodic, subtle clinical signs.…”

Section: Diagnostic Testing For Aerodigestive Disordersmentioning

confidence: 99%

“…Current diagnostic methods for reflux and aspiration in dogs lack sensitivity and specificity due to intermittent reflux events, variable client vigilance, small volumes of refluxate, and the presence of non-acidic refluxate, which may account for as many as 90% of events in people (19,112,113,117,121). Nuclear scintigraphy has potential to address many of these limitations and has been used successfully to detect reflux and aspiration people (127)(128)(129)(130)(131).…”

Section: Introductionmentioning

confidence: 99%

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Reflux, aspiration and respiratory disease in dogs : clinical consideration and advances in aerodigestive diagnostics

Grobman¹

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The aspiration of gastric contents into the respiratory tract has been associated with the development and progression of multiple respiratory diseases in humans. In veterinary medicine the term "aspiration" is considered synonymous with "aspiration pneumonia" which, while frequently encountered, does not accurately reflect the breadth of aspiration associated respiratory syndromes (AARS). In the clinical veterinary literature, the effect of alimentary dysfunction on respiratory disease (aerodigestive disease) is rarely investigated despite evidence in the human literature, animal models, and some studies and case reports linking alimentary and respiratory disease in clinical small animal patients. Aerodigestive disease is rarely investigated in veterinary medicine due to lack of clinical recognition and limitations in available diagnostics. Furthermore, AARS may be precipitated by several potentially occult alimentary disorders. Current methods of investigating aerodigestive diseases in veterinary patients are limited by sensitivity, specificity, potential for bias, cost, and availability. This necessitates investigations into advanced diagnostics to identify a potentially underrecognized patient population with AARS. Additionally, similarities in anatomy, physiology, and several pathologic disorders between dogs and humans, make experimental and naturally occurring canine models integral to translational research. Thus, evaluating dogs with aerodigestive disease may represent an area of substantial clinical relevance in human as well as veterinary medicine.

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Hiatal hernia repair and magnetic sphincter augmentation to treat laryngopharyngeal reflux aiding the prevention of recurrent laryngeal cancer

Smoot

Ward

Arviso

et al. 2020

Baylor University Medical Center Proceedings

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Diagnosis and Treatment of the Extraesophageal Manifestations of Gastroesophageal Reflux Disease

Cited by 4 publications

References 56 publications

Medical Therapy of Gastroesophageal Reflux Disease Beyond Proton Pump Inhibitors: Where Are We Heading

Medical Therapy of Gastroesophageal Reflux Disease Beyond Proton Pump Inhibitors: Where Are We Heading

Reflux, aspiration and respiratory disease in dogs : clinical consideration and advances in aerodigestive diagnostics

Hiatal hernia repair and magnetic sphincter augmentation to treat laryngopharyngeal reflux aiding the prevention of recurrent laryngeal cancer

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