Diagnosis and treatment of pituitary microadenoma: report of 80 cases

Zhang, Hongwei; Sun, Wei; Yang, Jun; Chen, Yan; Yu, Chunmei

doi:10.1179/174313208x310287

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…1 In the diagnostics of pancreatic duct stones, endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) have the highest levels of sensitivity. 2 Endoscopic retrograde cholangiopancreatography (ERCP) along with endoscopic sphincterotomy (ES) followed by stone extraction, in some cases also combined with extracorporeal shock wave lithotripsy (ESWL), is the preferred treatment for pancreatic duct stones. 3 The high rates of recurrence of pancreatolithiasis constitute a severe problem.…”

Section: Resultsmentioning

confidence: 99%

“…Due to its availability, low cost, reproducibility and noninvasive character, abdominal ultrasound is the first-line diagnostic approach in pancreatolithiasis. 2 However, the sensitivity of classic ultrasonography is much lower than EUS, MRCP or CT. 2,6 Calcifications of the pancreas may be also visible in a plain abdominal radiogram in as many as 30% of patients with chronic pancreatitis. 7 ERCP is both a diagnostic and a therapeutic procedure, allowing to determine the location, size and number of pancreatic stones and to distinguish true stones from false ones.…”

Section: Diagnosismentioning

confidence: 99%

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Pancreatic duct stones – a report of 16 cases

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Pancreatic duct stones – a report of 16 cases

et al. 2017

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The Diagnostic Value of Conventional MRI Combined With Diffusion‐Weighted Imaging in Microprolactinomas

Wang,

Yu,

Han

et al. 2024

Magnetic Resonance Imaging

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BackgroundTurbo spin‐echo (TSE) diffusion‐weighted imaging (DWI) sequences may reduce susceptibility artifacts and image distortion in sellar region, allowing better visualization of small pituitary lesions, and may be used to assist in the diagnosis of pituitary microadenomas.PurposeTo explore the application value of conventional MRI combined with DWI sequences in the diagnosis of microprolactinomas.Study TypeProspective.PopulationThirty‐four patients in microprolactinomas with high signal on T2WI (HT2‐PRL) group (34 females, 34 ± 7 years), 26 patients in microprolactinomas with equal or low signal on T2WI (ELT2‐PRL) group (21 females, 34 ± 7 years), 35 patients with hyperprolactinemia (33 females, 32 ± 8 years), and 30 normal controls (25 females, 31 ± 7 years).Field Strength/SequenceTSE sequence at 3 T.AssessmentPituitary morphological parameters (such as length and volume), dynamic contrast‐enhanced parameters (such as time to peak) and the apparent diffusion coefficients (ADCs) were measured in each group.Statistical TestsANOVA and Mann–Whitney U test were used to compare parameters among groups. Spearman's coefficient was used to evaluate the correlation between variables. ROC analysis was used to assess the performance of the parameters. A P‐value <0.05 was considered statistically significant.ResultsThe pituitary volume of patients in HT2‐PRL, ELT2‐PRL, and hyperprolactinemia group were 831.00 (747.60, 887.60), 923.63 ± 219.34, and 737.20 (606.40, 836.80) mm3. The pituitary maximum height in these three groups were 7.03 (6.43, 8.63), 8.03 ± 1.41, and 6.63 ± 1.28 mm, respectively. The lesion ADC value was significantly correlated with T2 relative signal intensity (the ratio of signal intensity of microprolactinoma or anterior pituitary to left temporal cortex) (r = 0.821). Compared with patients with hyperprolactinemia, the diagnostic efficacy of T2 relative signal intensity was higher in HT2‐PRL group, with an AUC of 0.954, whereas the ADC value was the highest in ELT2‐PRL group, with an AUC of 0.924.ConclusionDWI sequences can be used to assist in the diagnosis of pituitary microadenomas.Evidence Level1Technical EfficacyStage 2

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Treatment of hyperprolactinemia: a systematic review and meta-analysis

et al. 2012

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BackgroundHyperprolactinemia is a common endocrine disorder that can be associated with significant morbidity. We conducted a systematic review and meta-analyses of outcomes of hyperprolactinemic patients, including microadenomas and macroadenomas, to provide evidence-based recommendations for practitioners. Through this review, we aimed to compare efficacy and adverse effects of medications, surgery and radiotherapy in the treatment of hyperprolactinemia.MethodsWe searched electronic databases, reviewed bibliographies of included articles, and contacted experts in the field. Eligible studies provided longitudinal follow-up of patients with hyperprolactinemia and evaluated outcomes of interest. We collected descriptive, quality and outcome data (tumor growth, visual field defects, infertility, sexual dysfunction, amenorrhea/oligomenorrhea and prolactin levels).ResultsAfter review, 8 randomized and 178 nonrandomized studies (over 3,000 patients) met inclusion criteria. Compared to no treatment, dopamine agonists significantly reduced prolactin level (weighted mean difference, -45; 95% confidence interval, -77 to −11) and the likelihood of persistent hyperprolactinemia (relative risk, 0.90; 95% confidence interval, 0.81 to 0.99). Cabergoline was more effective than bromocriptine in reducing persistent hyperprolactinemia, amenorrhea/oligomenorrhea, and galactorrhea. A large body of noncomparative literature showed dopamine agonists improved other patient-important outcomes. Low-to-moderate quality evidence supports improved outcomes with surgery and radiotherapy compared to no treatment in patients who were resistant to or intolerant of dopamine agonists.ConclusionOur results provide evidence to support the use of dopamine agonists in reducing prolactin levels and persistent hyperprolactinemia, with cabergoline proving more efficacious than bromocriptine. Radiotherapy and surgery are useful in patients with resistance or intolerance to dopamine agonists.

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Diagnosis and treatment of pituitary microadenoma: report of 80 cases

Cited by 3 publications

References 21 publications

Pancreatic duct stones – a report of 16 cases

Pancreatic duct stones – a report of 16 cases

The Diagnostic Value of Conventional MRI Combined With Diffusion‐Weighted Imaging in Microprolactinomas

Treatment of hyperprolactinemia: a systematic review and meta-analysis

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