Diagnosis and Treatment of Musculotendinous Deficiencies of the Hip

Deckard, Evan R.; Meneghini, R. Michael

doi:10.1016/j.arth.2022.03.021

Cited by 2 publications

(2 citation statements)

References 23 publications

(23 reference statements)

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“…Data Diagnosis (DD) ( 58 ) performs diagnostic tests for both experimental design and experimental performance. These test for variables that are associated with variations in performance and identify which values of the variables are associated with good or bad performance.…”

Section: Methodsmentioning

confidence: 99%

Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop

Cummins

Vrana²,

Moseley

et al. 2023

Synthetic Biology

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Computational tools addressing various components of design–build–test–learn (DBTL) loops for the construction of synthetic genetic networks exist but do not generally cover the entire DBTL loop. This manuscript introduces an end-to-end sequence of tools that together form a DBTL loop called Design Assemble Round Trip (DART). DART provides rational selection and refinement of genetic parts to construct and test a circuit. Computational support for experimental process, metadata management, standardized data collection and reproducible data analysis is provided via the previously published Round Trip (RT) test–learn loop. The primary focus of this work is on the Design Assemble (DA) part of the tool chain, which improves on previous techniques by screening up to thousands of network topologies for robust performance using a novel robustness score derived from dynamical behavior based on circuit topology only. In addition, novel experimental support software is introduced for the assembly of genetic circuits. A complete design-through-analysis sequence is presented using several OR and NOR circuit designs, with and without structural redundancy, that are implemented in budding yeast. The execution of DART tested the predictions of the design tools, specifically with regard to robust and reproducible performance under different experimental conditions. The data analysis depended on a novel application of machine learning techniques to segment bimodal flow cytometry distributions. Evidence is presented that, in some cases, a more complex build may impart more robustness and reproducibility across experimental conditions.

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Section: Methodsmentioning

confidence: 99%

Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop

Cummins

Vrana²,

Moseley

et al. 2023

Synthetic Biology

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show abstract

“…Groin pain can be a problem following total hip arthroplasty (THA), often caused by aseptic loosening, periprosthetic joint infection or periprosthetic fracture [31,36]. Iliopsoas impingement against an overhanging cup [13,40], a bulging screw or protruding cement [36] could cause iliopsoas tendinopathy, which is often underdiagnosed when investigating the cause of groin pain [9,11,20]. Recent studies have reported an incidence of symptomatic iliopsoas tendinopathy between 2% and 11% following primary THA [4,23,34,37,40,44].…”

Section: Introductionmentioning

confidence: 99%

Satisfactory mid‐term clinical outcomes of endoscopic tenotomy for iliopsoas tendinopathy following total hip arthroplasty

Erard,

Viamont‐Guerra,

Bonin

2024

Knee surg. sports traumatol. arthrosc.

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PurposeTo report 5‐year outcomes of endoscopic iliopsoas tenotomy in patients with iliopsoas tendinopathy following total hip arthroplasty (THA) and determine whether clinical scores are associated with cup position.MethodsPatients who underwent endoscopic iliopsoas tenotomy for iliopsoas tendinopathy following THA (2014–2017) were contacted. Indications for endoscopic iliopsoas tenotomy after THA were groin pain during active hip flexion, exclusion of other causes of groin pain, and no pain relief after 6 months of conservative treatment. Pretenotomy cup inclination and anteversion were measured on radiographs; axial and sagittal cup overhang were measured on computed tomography (CT) scans. Oxford hip score (OHS), modified Harris hip score (mHHS), and groin pain were assessed.ResultsThe initial cohort comprised 16 men (17 hips) and 31 women (32 hips), aged 60.7 ± 10.6 years. Cup inclination and anteversion were, respectively, 46.2 ± 6.2° and 14.6 ± 8.4°, while axial and sagittal cup overhang were, respectively, 4.4 ± 4.0 mm and 6.9 ± 4.5 mm. At ≥5 years follow‐up, four hips underwent cup and stem revision, two underwent isolated cup revision and one underwent secondary iliopsoas tenotomy. OHS improved by 23 ± 10 and mHHS improved by 31 ± 16. Posttenotomy groin pain was slight in 20.0%, mild in 17.5% and moderate in 12.5%. Regression analyses revealed that net change in mHHS decreased with sagittal cup overhang (β = –3.1; 95% confidence interval [CI] = –4.6 to –1.7; p < 0.001), but that there were no associations between cup position and net change in OHS.ConclusionsEndoscopic iliopsoas tenotomy provides good mid‐term clinical outcomes in patients with iliopsoas tendinopathy following THA. Furthermore, improvements in mHHS were found to decrease with increasing sagittal cup overhang, in cases for which adequate preoperative imaging was available.Level of EvidenceLevel IV.

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Diagnosis and Treatment of Musculotendinous Deficiencies of the Hip

Cited by 2 publications

References 23 publications

Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop

Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop

Satisfactory mid‐term clinical outcomes of endoscopic tenotomy for iliopsoas tendinopathy following total hip arthroplasty

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