Diagnosis and Treatment of Malignant Pleural Mesothelioma

Panadero, Francisco Rodríguez

doi:10.1016/j.arbr.2015.02.009

Cited by 19 publications

(18 citation statements)

References 102 publications

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“…MT as a real-time invasive procedure enables clinicians to improve tumor staging, particularly in the mediastinal region, by enabling the exact sampling point with adequate tissue for biopsy. Our current data support the consideration that MT is considered the best way for making diagnosis of MPM [ 23 ].…”

Section: Discussionsupporting

confidence: 85%

Malignant pleural mesothelioma: diagnostic value of medical thoracoscopy and long-term prognostic analysis

Xu¹,

Yang

Wang

et al. 2018

BMC Pulm Med

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BackgroundMalignant pleural mesothelioma (MPM) is marked by its difficult diagnosis and poor prognosis. Medical thoracoscopy (MT) is an effective and safe procedure for the diagnosis of exudative pleural effusions and many factors associated with poor prognosis of MPM. We conducted this study to investigate the value of MT for diagnosing of MPM and to identify prognostic factors for MPM patients.MethodsFrom July 2005 through June 2014, a total of 833 patients with undiagnosed pleural effusions underwent MT and pleural biopsies were taken. Clinical data of all patients with MPM were retrospectively analyzed, and those with complete follow-up data were analyzed for prognostic factors.ResultsEventually, MPM was the final diagnosis in 40 patients. Diagnostic efficiency of MT for MPM was 87.5%, since diagnosis of MPM failed to be established in 5 patients during the initial MT. Median survival was 17.1 mo (95% confidence interval: 13.6–20.7 mo). MT findings of pleural adhesion and plaques were adverse prognostic factors for MPM. In addition, old age, male gender, smoking history, histological type, poor staging, no treatment, low total protein level in pleural fluid, and computed tomographic findings such as pulmonary consolidation or infiltration, mediastinal lymphopathy, pulmonary mass or nodules, and pleural nodularity were also poor prognostic factors for MPM.ConclusionsMT is safe with a high positive rate in the diagnosis of MPM, and pleural adhesion and plaques seen under MT may be the adverse prognostic factors for MPM. Multiple clinical characteristics can affect the survival of MPM patients.

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Section: Discussionsupporting

confidence: 85%

Malignant pleural mesothelioma: diagnostic value of medical thoracoscopy and long-term prognostic analysis

Xu¹,

Yang

Wang

et al. 2018

BMC Pulm Med

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“…Wierman et al reported in 1954 that HOA was present in 60% of fibrous tumors of the pleura . In their paper, the detailed correlation between malignant mesothelioma and HOA was not described, and immunostaining, which is considered essential to diagnose malignant mesothelioma, was not performed . The diagnosis of malignant mesothelioma was immunohistochemically confirmed in our patient.…”

Section: Discussionmentioning

confidence: 77%

A case of severe arthralgia with malignant mesothelioma‐associated hypertrophic osteoarthropathy

Yamakawa

Sekine

Kato

et al. 2016

Clinical Case Reports

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“…Aside from careful and thorough history and physical examination, imaging is an early diagnostic tool in the evaluation of patients with suspected MPM. PET in addition to CT may add additional information but has poor sensitivity and may be confused for other pleural diseases [7]. FDG-PET may be a better modality in investigating lymphadenopathy as well as metastatic disease [8].…”

Section: Discussionmentioning

confidence: 99%

A 75 year old male with recurrent unilateral pleural effusion and positive ANA

Wallen

Jagan

Krishnan

et al. 2019

Respiratory Medicine Case Reports

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This case report describes the clinical course and diagnostic challenges arising in a 75 year old man who initially presented with progressive shortness of breath. Imaging revealed a pleural effusion, which was recurrent following thoracentesis. While his initial workup suggested an autoimmune etiology, further diagnostic testing revealed a diagnosis of malignant pleural mesothelioma. Curiously, the patient had no known asbestos exposure, which is classically associated with acquired mesothelioma. There are a small number of similar cases with a possible overlap between positive autoimmune serologies and mesothelioma; however, the underlying pathophysiology remains elusive. It is the authors' goal to contribute this case to the few cases describing such overlap syndromes.

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Diagnosis and Treatment of Malignant Pleural Mesothelioma

Cited by 19 publications

References 102 publications

Malignant pleural mesothelioma: diagnostic value of medical thoracoscopy and long-term prognostic analysis

Malignant pleural mesothelioma: diagnostic value of medical thoracoscopy and long-term prognostic analysis

A case of severe arthralgia with malignant mesothelioma‐associated hypertrophic osteoarthropathy

A 75 year old male with recurrent unilateral pleural effusion and positive ANA

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