Diagnosis and Treatment of Lymphocutaneous Sporotrichosis: What Are the Options?

Bonifáz, Alexandro; Vázquez-González, Denisse

doi:10.1007/s12281-013-0140-3

Cited by 37 publications

(46 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although there are numerous oral drugs which can be utilized to treat sporotrichosis, the two agents which are most widely used are potassium iodide (KI) and itraconazole, with the former being the treatment of choice in developing nations. 9 While the usual dosage of itraconazole is 200 mg per day, it can be increased up to 200 mg twice daily if the clinical response is poor. 3 Itraconazole should be administered until 2-4 weeks after all lesions have resolved, with a total treatment duration of 3-6 months.…”

Section: Discussionmentioning

confidence: 99%

Lymphocutaneous Sporotrichosis in a Patient with Underlying Systemic Lupus Erythematosus

Wahab

Ding

Yusoff³

2019

J. Medicine

View full text Add to dashboard Cite

Sporotrichosis is a globally prevalent subcutaneous mycosis commonly acquired through traumatic inoculation. A 66-year-old woman with underlying systemic lupus erythematosus (SLE) presented initially with a painful non-healing nodule on her right thumb. There was no history of traumatic contact with soil, plants or animals. She was started on an antibiotic but developed multiple nodules on her right forearm which appeared to spread proximally. Culture of her skin biopsy specimen yielded Sporothrix schenckii. The lesions were successfully treated with oral itraconazole. In conclusion, a history of traumatic inoculation need not always be present in SLE patients with sporotrichosis and obtaining a laboratory diagnosis is crucial for those presenting with nodular skin lesions that spread proximally J MEDICINE JAN 2020; 21 (1) : 59-61

show abstract

Section: Discussionmentioning

confidence: 99%

Lymphocutaneous Sporotrichosis in a Patient with Underlying Systemic Lupus Erythematosus

Wahab

Ding

Yusoff³

2019

J. Medicine

View full text Add to dashboard Cite

show abstract

“…En contraste, en la epidemia de esporotricosis de transmisión zoonótica en Brasil (S. brasiliensis), la infección fue transmitida por gatos, los que cursan con una infección diseminada con lesiones extensas con levaduras abundantes 1,9,18 . Tradicionalmente, el tratamiento de primera elección ha sido el yoduro de potasio, el que es el más utilizado en países subdesarrollados por ser efectivo, bien tolerado y de bajo costo; sin embargo, con algunos efectos colaterales 1,4,19 . Su uso se reserva a la forma cutánea-fija y linfangítica.…”

Section: Discussionunclassified

“…En pacientes inmunocomprometidos o casos con enfermedad diseminada la dosis debe elevarse a 300-400 mg al día 2,[19][20][21][22] . Terbinafina parece ser menos efectiva en la práctica que itraconazol (aunque in vitro presenta CIM más bajas) 19 , sin embargo, en un estudio comparativo se encontró que 250 mg al día de terbinafina fue igualmente efectivo que 100 mg al día de itraconazol 22 . Es una buena alternativa al itraconazol en caso de intolerancia o por múltiples interacciones farmacológicas 19 .…”

Section: Discussionunclassified

Esporotricosis del pabellón auricular. Comunicación de un caso atípico simulando una celulitis bacteriana

Ochoa-Reyes¹,

Ramos-Martínez

Treviño-Rangel

et al. 2018

Rev. chil. infectol.

Self Cite

View full text Add to dashboard Cite

Sporotrichosis is the most common subcutaneous or implantation mycosis in Mexico. The case of a preauricular cutaneous-fixed sporotrichosis simulating atypical bacterial cellulitis is reported in an elderly patient with no history of trauma. The biopsy showed a suppurative granuloma with scarce yeast. Sporothrix schenckii was identified in the culture and confirmed by molecular biology. She was treated with itraconazole and a clinical and mycological cure was obtained. The case of atypical presentation is presented, coming from a semi-arid zone with extreme weather.Key words: Sporotrichosis; Sporothrix schenckii; fixed-cutaneous; bacterial cellulitis; itraconazole; PCR Palabras clave: Esporotricosis; Sporothrix schenckii; cutánea-fija, celulitis bacteriana; itraconazol, RPC.Introducción L a esporotricosis es una micosis generalmente subcutánea, de curso subagudo o crónico. Es causada por hongos dimorfos comprendidos dentro del complejo Sporothrix schenckii, del cual se han identificado seis especies, siendo las tres más frecuentes y patógenas: S. schenckii (sensu stricto), Sporothrix brasiliensis, y Sporothrix globosa; y ocasionales: Sporothrix mexicana, Sporothrix lurei y Sporothrix pallida [1][2][3] . Es la micosis por implantación más ampliamente distribuida en el mundo y se observa con mayor frecuencia tanto en regiones intertropicales como en climas templados 1,4,5 . Las diversas especies del complejo Sporothrix viven en el suelo, materia orgánica, plantas, paja, ramas, zacate y musgos. La infección se adquiere por inoculación traumática con material contaminado y puede transmitirse como una zoonosis por animales domésticos como perros y en especial, gatos. Se consideran grupos de riesgo de presentar la enfermedad: habitantes del medio rural, horticultores, trabajadores forestales, floristas y carpinteros. Por este motivo, la esporotricosis se le ha llamado la "enfermedad de los jardineros" o la "enfermedad de los cultivadores de rosas"

show abstract

“…3 Sporotrichosis can be distinguished from other skin diseases, such as leishmaniasis, tuberculosis, sarcoidosis, paracoccidioidomycosis, and chromoblastomycosis. 4 Developments in molecular phylogeny have clarified species boundaries and suggest that there are several cryptic species of clinical interest, including Sporothrix brasiliensis, Sporothrix schenckii s.s., Sporothrix globosa, and Sporothrix luriei.…”

Section: Introductionmentioning

confidence: 99%

Atypical Clinical Presentation of Sporotrichosis Caused by Sporothrix globosa Resistant to Itraconazole

Gompertz¹,

Rodrigues²,

Fernandes³

et al. 2016

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Sporotrichosis is a polymorphic disease of humans and animals, which is acquired via traumatic inoculation of Sporothrix propagules into cutaneous or subcutaneous tissue. The etiological agents are in a clinical complex, which includes Sporothrix brasiliensis, Sporothrix schenckii, Sporothrix globosa, and Sporothrix luriei, each of which has specific epidemiological and virulence characteristics. Classical manifestation in humans includes a fixed localized lesion at the site of trauma plus lymphocutaneous sporotrichosis with fungal spreading along the lymphatic channels. Atypical sporotrichosis is a challenge to diagnosis because it can mimic many other dermatological diseases. We report an unusual, itraconazoleresistant cutaneous lesion of sporotrichosis in a 66-year-old Brazilian man. Histopathological examination of the skin revealed vascular and fibroblastic proliferation with chronic granulomatous infiltrate composed of multinucleated giant cells. Sporothrix were isolated from the skin lesion, and phylogenetic analyses confirmed it to be sporotrichosis due to S. globosa, a widespread pathogen. Immunoblotting analysis showed several IgG-reactive molecules in autochthonous preparations of the whole cellular proteins (160, 80, 60, 55, 46, 38,35, and 30 kDa) and exoantigen (35 and 33 kDa). The patient was first unsuccessfully treated with daily itraconazole, and then successfully treated with potassium iodide.

show abstract

Diagnosis and Treatment of Lymphocutaneous Sporotrichosis: What Are the Options?

Cited by 37 publications

References 47 publications

Lymphocutaneous Sporotrichosis in a Patient with Underlying Systemic Lupus Erythematosus

Lymphocutaneous Sporotrichosis in a Patient with Underlying Systemic Lupus Erythematosus

Esporotricosis del pabellón auricular. Comunicación de un caso atípico simulando una celulitis bacteriana

Atypical Clinical Presentation of Sporotrichosis Caused by Sporothrix globosa Resistant to Itraconazole

Contact Info

Product

Resources

About