Diagnosis and treatment of lymph node metastases of a rectal carcinoid tumor using In111-octreotide-scintigraphy and intraoperative gamma probe detection

Rossetti, Antonio Carlos; Travaglia, T; Rossini, Pierluigi; Odeh, Majed; Arru, Luca; Ragni, Fulvio

doi:10.1016/j.ijscr.2011.01.002

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The majority of published studies using OCT described a 24-72-h interval between administration and surgery. Even though this is a much shorter period than suggested as optimal by Wang, 10 of the 11 authors described how RGS benefitted the surgeon by identifying additional foci over other techniques [10][11][12]15,16,18,19 ; minimising the extent or duration of surgery [12][13][14]16 ; assisting with differentiation between normal tissue and tumour 12,13,15 ; and /or aiding the surgeon in localising the tumour 12,[15][16][17] .…”

Section: Rgs With Indium-111 Pentetreotide (Oct)mentioning

confidence: 99%

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review

Cockburn

Toumi

Mackie

et al. 2021

Journal of Gastrointestinal Surgery

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Background Radioguided surgery (RGS) for gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has been suggested as a way to improve intraoperative lesion detection. This systematic literature review of reports of the use of RGS for GEP-NETs was performed to determine if there is a benefit. Methods A literature search was conducted using Google Scholar and PubMed, and snowballing from any relevant literature. Full-text studies were included if they were published in the English language and reported outcomes of RGS on human subjects with GEP-NETs. Qualitative data synthesis was performed. Results Twenty-six papers including a total of 209 patients were included. The tracers used were predominantly indium-111 pentetreotide, gallium-68 DOTA-peptides, and technetium-99m EDDA/HYNIC-peptides. Heterogeneous protocols make comparisons difficult, but most papers reported a benefit from the use of RGS in tumours in the gastrointestinal tract; utility in localisation of pancreatic tumours was less clear. Time between tracer administration and operation varied: from 16 h to 8 days with indium-111, 0–24 h with technetium-99m, and 19–193 min with gallium-68. Eight teams reported the thresholding technique used for discrimination—four used a ratio, four statistical methods, and one looked at the sensitivity and specificity of different cut-offs. Six teams performed follow-up of 24 patients (three pancreas, eight gastrinoma, 13 gastrointestinal tract) for between 3 months and 3 years. Two patients relapsed (one pancreas, one gastrinoma) between 6 and 12 months post-surgery. Conclusions RGS appears to aid in localisation of gastrointestinal NETs, but the benefit is more equivocal in pancreatic NETs. Further work into outcomes is warranted.

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Section: Rgs With Indium-111 Pentetreotide (Oct)mentioning

confidence: 99%

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review

Cockburn

Toumi

Mackie

et al. 2021

Journal of Gastrointestinal Surgery

View full text Add to dashboard Cite

show abstract

“…The majority of published studies using OCT described a 24-72 hour interval between administration and surgery. Even though this is a much shorter period than suggested as optimal by Wang, 10 of the 11 authors described how RGS bene tted the surgeon by: identifying additional foci over other techniques [11][12][13][14][15][16][17]; minimising the extent or duration of surgery [12,16,18,19]; assisting with differentiation between normal tissue and tumour [12,15,18]; and /or aiding the surgeon in localising the tumour [12,15,16,20].…”

Section: Study Characteristicsmentioning

confidence: 99%

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours; a Systematic Literature Review

Cockburn

Toumi

Mackie

et al. 2021

Preprint

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Background:Radioguided surgery (RGS) for gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has been suggested as a way to improve intraoperative lesion detection. This systematic literature review of reports of the use of RGS for GEP-NETs was performed to determine if there is a benefit.Methods: A literature search was conducted using Google Scholar and PubMed, and snowballing from any relevant literature. Full-text studies were included if they were published in the English Language and reported outcomes of RGS on human subjects with GEP-NETs. Qualitative data synthesis was performed. Results: 26 papers including a total of 209 patients were included. The tracers used were predominantly indium-111 pentetreotide, gallium-68 DOTA-Peptides, and technetium-99m EDDA/HYNIC-Peptides. Heterogeneous protocols make comparisons difficult, but most papers reported a benefit from the use of RGS in tumours in the gastrointestinal tract; utility in localisation of pancreatic tumours was less clear. Time between tracer administration and operation varied; from 16 hours to 8 days with indium-111, 0-24 hours with technetium-99m and 19-193 minutes with gallium-68. Eight teams reported the thresholding technique used for discrimination – four used a ratio, four statistical methods, and one looked at the sensitivity and specificity of different cut-offs. Six teams performed follow-up of 24 patients (three pancreas, eight gastrinoma, 13 gastrointestinal tract) for between 3 months and 3 years. Two patients relapsed (one pancreas, one gastrinoma) between six and 12 months post-surgery. Conclusions:RGS appears to aid in localisation of gastrointestinal NETs, but the benefit is more equivocal in pancreatic NETs. Further work into outcomes is warranted.

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Pediatric Neuroendocrine Carcinoid Tumors: Review of Diagnostic Imaging Findings and Recent Advances

Degnan

Tadros

Tocchio

2017

American Journal of Roentgenology

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Improvements in functional imaging with novel somatostatin receptor-specific radiotracers along with fused functional and anatomic imaging have substantially improved the clinical detection of carcinoid tumors. Although rare, these tumors are encountered in children, and an awareness of the appropriate use of various imaging methods is essential for pediatric specialists. Further research is needed to ascertain the diagnostic value of newer imaging methods and radiotracer-based treatment approaches, especially in the pediatric population.

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Diagnosis and treatment of lymph node metastases of a rectal carcinoid tumor using In111-octreotide-scintigraphy and intraoperative gamma probe detection

Abstract: Carcinoids represent 1-2% of the rectal cancer. We report the case of a woman with a rectal carcinoid and a hypogastric node metastasis. We propose a less invasive treatment of the metastase using In11-octreotide-scintigraphy and intraoperative gamma-probe detector.

Cited by 3 publications

References 15 publications

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours; a Systematic Literature Review

Pediatric Neuroendocrine Carcinoid Tumors: Review of Diagnostic Imaging Findings and Recent Advances

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