Diagnosis and Treatment of Lyme Disease

Bratton, Robert L.; Whiteside, John W.; Hovan, Michael J.; Engle, Richard L.; Edwards, Frederick D.

doi:10.1016/s0025-6196(11)60731-3

Cited by 99 publications

(62 citation statements)

References 23 publications

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“…The respondents reported myalgia (74%), arthritis (64%), rheumatoid changes (41%), myocarditis (28%) as other symptoms of Lyme disease. These symptoms are characteristic of disseminated and late stage of the disease, which has been confirmed by the literature data [12,16]. In the opinion of 7% of the interviewed subjects, dyspnoea is also a symptom of the disease.…”

Section: Discussionsupporting

confidence: 77%

“…In the case of Lyme disease, infections have favourable conditions for development due to a high percentage of forested areas, the presence of numerous tourist and holiday centres, as well as propagation of healthy lifestyle. The endemic areas are those in which the percentage of the infected ticks is quite high [4,11,12]. In 2008, the National Hygiene Department considered provinces with the highest disease incidence as endemic, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…This is a manifestation of an inflammatory process; however, 30% of the respondents think that this is the sign of the disease. lesions (erythema migrans) are the first symptoms of the disease, while fever only rarely accompanies the lesions [4,12]. The respondents reported myalgia (74%), arthritis (64%), rheumatoid changes (41%), myocarditis (28%) as other symptoms of Lyme disease.…”

Section: Discussionmentioning

confidence: 99%

“…In the opinion of 7% of the interviewed subjects, dyspnoea is also a symptom of the disease. It results from severe lesions of the atrio-ventricular block [12,16]. According to 10-11% of the respondents, vomiting and nausea were the symptoms of Lyme disease; actually, however, they are rarely observed and appear only in association with cerebrospinal meningitis.…”

Section: Discussionmentioning

confidence: 99%

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Knowledge on Lyme disease among foresters

Kurnatowski¹,

Warpechowska²,

Kurnatowska³

2011

International Journal of Occupational Medicine and Environmental Health

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Objectives: The first aim was an attempt to evaluate the level of knowledge on Lyme disease among people whose profession involves working in the forest; the second -recognition of the health problems that should be included in health education programmes concerning Lyme disease in this group of professionals. Materials and Methods: The study was performed on 159 subjects. Results: Only 15% know the etiological factor of disease, 98% -the main cause of infection, and route of pathogen transmission. Conclusion: Propagation of knowledge on Lyme disease, particularly among risk group people, is not satisfactory. Little knowledge on tick risk among secondary school students indicate the necessity for cooperation between teachers, epidemiologists, and health service providers in order to propagate the knowledge on parasites, symptoms, spread and methods of prevention.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Knowledge on Lyme disease among foresters

Kurnatowski¹,

Warpechowska²,

Kurnatowska³

2011

International Journal of Occupational Medicine and Environmental Health

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“…This may be due to the actual spread of the disease and/ or alternatively to improved diagnostic methods. 4 In Cuba, Lyme disease has not been officially reported, although specific antibodies against B. burgdorferi sensu lato complex, measured by ELISA and Western blot techniques, have been found in individuals that have presented compatible clinical manifestations with this borreliosis. [6][7][8] The aim of the present study was to estimate the prevalence of specific antibodies to B. burgdorferi sensu stricto in a human population from Cuba, in order to continue the investigations about the presence of this pathogen in the country.…”

mentioning

confidence: 99%

Prevalence of antibodies to Borrelia burgdorferi sensu stricto in humans from a Cuban village

Rodríguez¹,

Fernández²,

Sánchez³

et al. 2012

Braz J Infect Dis

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Methods: Serum specimens from 247 persons randomly selected from the population of the village were examined by IgG Western blot using B31 strain for estimating the prevalence of antibodies profile.Results: A seroprevalence value interval (95% CI) of 0.6%-7.2% was estimated for the studied population. The prevalent borrelial protein bands on immunoblots were 41, 72, 90/93, 34, 47, 60, 58, 56, 65/66 and 31 kDa in a decreasing order of significance. Conclusion:These results support the previous serological findings, suggesting the presence of this borreliosis in Cuba.

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Structure-Based Design of Diagnostics and Vaccines for Lyme Disease

Thomas

2021

Vaccine Design

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Changes in climate have increased the geographical range of insect vectors responsible for the transmission of several diseases. Lyme disease, caused by the bacterial pathogen Borrelia burgdorferi, has become recognized as the most prevalent arthropod-borne infection in the USA. It is transmitted to humans through the bite of infected blacklegged ticks. As yet, there are no commercial vaccines available that effectively provide protection against Lyme disease. Vaccination strategies involving use of subunit vaccines developed in many laboratories have been found to be less efficient in protecting against the disease. Hence, there is a need to develop powerful vaccines that provide robust protection against Borrelia. Recently, using the principle of structure-based design, we designed and developed novel diagnostics and vaccine candidates that protected against Lyme disease in animal models. This chapter describes design and development of peptides based on the principle of structure-based design for use in diagnostics and vaccines to protect against Lyme disease in an animal model.

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Diagnosis and Treatment of Lyme Disease

Cited by 99 publications

References 23 publications

Knowledge on Lyme disease among foresters

Knowledge on Lyme disease among foresters

Prevalence of antibodies to Borrelia burgdorferi sensu stricto in humans from a Cuban village

Structure-Based Design of Diagnostics and Vaccines for Lyme Disease

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