Diagnosis and treatment of interstitial cystitis (IC/PBS)

Bschleipfer, T.; Doggweiler, Ragi; Schultz-Lampel, D.; Jong, Jeroen de; Gonsior, Andreas; Hensen, J.; Heßdörfer, Elke; Kaftan, Björn Theodor; Kühn, Annette; Kunzendorf, Ulrich; Lampel, A.; Landmesser, A; Loch, Alexander; Moormann, Oliver; Müller, Bert; Neuhaus, Jochen; Reich, Andreas; Roth, Rebecca; Schumacher, Stefan; Stratmeyer, R; Vahlensieck, W.; Wördehoff, A.; Münder-Hensen, B

doi:10.1007/s00120-019-01054-2

Cited by 11 publications

(8 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IC treatment alternatives are very diverse, and the desired response level cannot be obtained from oral treatments. 4 Due to the limitation of oral treatments, intravesical treatments that can provide more intensive use of therapeutic agents in the bladder and have less systemic side effects are used effectively. Intravesical treatments such as chondroitin sulfate and hyaluronic acid instillations have come to the forefront in addition to the intravesical treatments recommended in the guidelines, such as lidocaine, heparin, and dimethylsulfoxide.…”

Section: Introductionmentioning

confidence: 99%

“…The incomplete understanding of the pathophysiology also complicates the development of effective treatment models. IC treatment alternatives are very diverse, and the desired response level cannot be obtained from oral treatments 4 . Due to the limitation of oral treatments, intravesical treatments that can provide more intensive use of therapeutic agents in the bladder and have less systemic side effects are used effectively.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of intravesical tarantula cubensis extract (Theranekron) on inflammation in an interstitial cystitis rat model

Abdullah¹,

Yenisey

Tuğrul

et al. 2022

LUTS

View full text Add to dashboard Cite

Objectives: To reveal the histopathological and immunological outcomes of intravesical treatment with tarantula cubensis extract (TCE) in a rat model of interstitial cystitis.Methods: A total of 30 female Wistar albino rats were divided into three groups: group 1 (control group), group 2 (disease group), and group 3 (treatment group). The rat model of interstitial cystitis was created by biweekly intraperitoneal administration of cyclophosphamide (CYP). In group 3, TCE (a venom extracted from a brown spider known as tarantula cubensis) was administered intravesically after the model

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of intravesical tarantula cubensis extract (Theranekron) on inflammation in an interstitial cystitis rat model

Abdullah¹,

Yenisey

Tuğrul

et al. 2022

LUTS

View full text Add to dashboard Cite

show abstract

“…2 The pathogenesis behind BPS remains unclear with several theories proposed such as neuronal hyperactivity, inflammation, histamine intolerance and damage to the glycosaminoglycans (GAG) layer. 3 The GAG layer is a complex set of proteoglycans and glycoproteins that cover the bladder mucosa and plays an important role in preventing bacterial adhesion and penetration of noxious substances from the urine. 4 In patients with BPS, it is postulated that disruption of this layer leaves patients with significant symptoms and deterioration in their quality of life.…”

Section: Introductionmentioning

confidence: 99%

“…4 In patients with BPS, it is postulated that disruption of this layer leaves patients with significant symptoms and deterioration in their quality of life. 3 Studies suggest that exogenously produced GAGs may bind to the damaged urothelium to ‘repair’ barrier defects. 3…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Elmiron (pentosanpolysulphate sodium) with pigmented maculopathy: An update for urologists and patients

Kailavasan

Goddard

2021

Journal of Clinical Urology

View full text Add to dashboard Cite

Introduction: Bladder pain syndrome (BPS) is a difficult disorder to diagnose and manage with a limited number of treatment options that have a good evidence base. Elmiron (pentosanpolysulphate sodium (PPS)) is recognised as a main second-line treatment option in many international guidelines. Recently published retrospective studies suggest that there is an association between Elmiron and pigmented maculopathy, a rare disease associated with visual impairment. Objectives: To review the known literature on Elmiron and pigmented maculopathy and alternative oral pharmacotherapy options for BPS. To promote awareness on this topic and aid urologists in managing Elmiron prescription. Methods: We reviewed the most commonly used oral treatments for BPS, in particular Elmiron, the current evidence to support this association with eye disease and its position in the management pathway of this complex condition. Conclusions: Recent retrospective longitudinal studies have demonstrated an association of Elmiron with pigmented maculopathy. However, as yet the exact nature of this relationship is unknown. Nevertheless, Elmiron remains an important part of the treatment pathway for BPS. We suggest clinicians should fully inform patients of this association, including patients who have been previously comenced on Elmiron. There should be ongoing and continuing reviews of all treatments to review its efficacy in indiviual patients. Level of evidence: Not applicable

show abstract

Rehabilitation der interstitiellen Zystitis

Vahlensieck

Zermann

2023

Die Urologie

View full text Add to dashboard Cite

Diagnosis and treatment of interstitial cystitis (IC/PBS)

Cited by 11 publications

References 98 publications

Effect of intravesical tarantula cubensis extract (Theranekron) on inflammation in an interstitial cystitis rat model

Effect of intravesical tarantula cubensis extract (Theranekron) on inflammation in an interstitial cystitis rat model

Association of Elmiron (pentosanpolysulphate sodium) with pigmented maculopathy: An update for urologists and patients

Rehabilitation der interstitiellen Zystitis

Contact Info

Product

Resources

About