Diagnosis and Treatment of Hypogonadism in the Male*

Evolutionary changes in the physiological control of mating behavior in mammals.

“…Regardless of the age at operation, it is possible to bring out normal coital responses in the ovariectomized female during adulthood by the injection of the appropriate ovarian hormones. This has been found true in the case of the guinea pig (25), hamster (49), mouse (84), rat (16), dog (66), cat (8), ferret (76), sheep (78) and cow (1). The only published study dealing with subanthropoid primates indicates that although the female rhesus monkey refuses the male after loss of the gonads, she will become sexually receptive if estrogen is injected.…”

“…Ovariectomy of prepuberal rats, guinea pigs, rabbits, and other lower mammals precludes the occurrence of mating responses in adulthood (117), and similar operation after the attainment of reproductive maturity promptly and permanently abolishes all manifestations of sexual heat in rodents (60,103,112), ungulates (3,78) and carnivores (8,66,68,71). Regardless of the age at operation, it is possible to bring out normal coital responses in the ovariectomized female during adulthood by the injection of the appropriate ovarian hormones.…”