Diagnosis and treatment of cutaneous paraneoplastic disorders

Velez, Ana Maria Abreu; Howard, Michael S.

doi:10.1111/j.1529-8019.2010.01371.x

Cited by 56 publications

(36 citation statements)

References 75 publications

(442 reference statements)

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“…However, the expression of collagen III is regulated by the activity of local fibroblasts [6]. Collagen IV, as a major component of the BM, participates in the inflammatory responses during tissue repair [7, 28, 29], principally via cellular regulation and migration [9, 30]. Indeed, Col4a1 (human collagen IV gene) mutation-associated phenotypic features include chronic inflammation and immune activation [10, 11].…”

Section: Discussionmentioning

confidence: 99%

Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF‐κB Activation

et al. 2016

Oxidative Medicine and Cellular Longevity

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Fibroblasts are essential for tissue repair due to producing collagens, and lysosomal proteinase cathepsin B (CatB) is involved in promoting chronic inflammation. We herein report that CatB regulates the expression of collagens III and IV by fibroblasts in response to a TLR2 agonist, lipopolysaccharide from Porphyromonas gingivalis (P.g. LPS). In cultured human BJ fibroblasts, mRNA expression of CatB was significantly increased, while that of collagens III and IV was significantly decreased at 24 h after challenge with P.g. LPS (1 μg/mL). The P.g. LPS-decreased collagen expression was completely inhibited by CA-074Me, the specific inhibitor of CatB. Surprisingly, expression of collagens III and IV was significantly increased in the primary fibroblasts from CatB-deficient mice after challenge with P.g. LPS. The increase of CatB was accompanied with an increase of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and a decrease of IκBα. Furthermore, the P.g. LPS-increased 8-OHdG and decreased IκBα were restored by CA-074Me. Moreover, 87% of CatB and 86% of 8-OHdG were colocalized with gingival fibroblasts of chronic periodontitis patients. The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-κB activation and oxidative stress. CatB-specific inhibitors may therefore improve chronic inflammation-delayed tissue repair.

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Section: Discussionmentioning

confidence: 99%

Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF‐κB Activation

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…The most common skin paraneoplastic manifestations are acanthosis nigricans, erythromelalgia, thrombotic thrombocytopenic purpura, acrokeratosis paraneoplastica, paraneoplastic hypertrichosis lanuginosa acquisita, dermatomyositis, systemic sclerosis, and scleroderma [11–13]. …”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Presenting as Paraneoplastic Erythroderma: An Extremely Rare Case

Protopsaltis

Drossou

Katsantonis

et al. 2014

Case Reports in Medicine

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The skin may exhibit the first clinical evidence of a systemic disease and may provide the first clues to a diagnosis in malignancies. Erythroderma is defined as generalized redness and scaling and it is a clinical manifestation of a variety of underlying diseases including, rarely, solid tumors. Breast cancer is associated with a variety of skin paraneoplastic manifestations like acanthosis nigricans, erythromelalgia, thrombotic thrombocytopenic purpura, acrokeratosis paraneoplastica, dermatomyositis, systemic sclerosis, and scleroderma. However, in the literature, the correlation of erythroderma with breast cancer is quite infrequent. Here, we describe a case of a 76-year-old woman who presented with a paraneoplastic manifestation of erythroderma due to breast cancer.

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“…The pathogenesis of Bazex syndrome remains unknown. It may be caused by the production of epidermal growth factor by tumor cells or by cross-reactivity between epidermal and tumor antigens [5]. In approximately 90% of all cases, the dermatosis follows the neoplastic course with an improvement after the effective treatment of the neoplasia [6] and a recurrence when the tumor returns.…”

Section: Discussionmentioning

confidence: 99%