Diagnosis and treatment of classic and iatrogenic Kaposi's sarcoma: Italian recommendations

Brambilla, Lucia; Genovese, Giovanni; Berti, Emilio; Peris, Ketty; Rongioletti, Franco; Micali, Giuseppe; Ayala, Fabio; Bella, Silvia Della; Mancuso, Roberta; Pinton, Piergiacomo Calzavara; Tourlaki, Athanasia

doi:10.23736/s2784-8671.20.06703-6

Cited by 22 publications

(59 citation statements)

References 79 publications

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“…KS lesions initially present as macules or patches (macular-patch stage), and subsequently evolve into plaque (plaque stage/plaque stage) and nodules (nodular-tumoral stage/nodular-tumor stage). There is currently no standard treatment for KS, but it depends on the extent and location of the lesions, as well as the clinical type of the disease [3]. Local therapies include different approaches, depending on the characteristics of the sarcoma, such as clinical monitoring, use of compression stockings for the prevention of lymphedema, surgery, cryotherapy, radiotherapy, intralesional chemotherapy and laser therapy [4,5].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Safety of Treatment with Neodymium:YAG Laser 1064 nm in Patients with Classic and Epidemic Kaposi Sarcoma

et al. 2022

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Kaposi’s sarcoma (KS) is a vascular neoplasm Herpes Virus 8 (HHV8), which can affect the skin, mucous membranes and viscera. There is currently no standard treatment for KS; this study evaluated the efficacy and safety of Neodymium:YAG (Nd:YAG) laser 1064 nm treatment in patients with classic and HIV-associated KS. 15 patients with classic KS (group A) and 15 with epidemic KS (group B), with exclusively cutaneous localization, were treated with Nd:YAG laser 1064 nm. Four treatment sessions were performed at 4 weeks intervals. 24/30 (80%) of treated patients underwent clinical improvement. Better results have been obtained in HIV-positive patients, especially in terms of reduced lesion size and the flattening of elevated lesions. The 1064 nm Nd:YAG laser is effective and safe in the treatment of classic and epidemic KS, especially in patients with symptomatic, slow-progressing local disease, where other treatment options may be inappropriate.

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Section: Introductionmentioning

confidence: 99%

Effectiveness and Safety of Treatment with Neodymium:YAG Laser 1064 nm in Patients with Classic and Epidemic Kaposi Sarcoma

et al. 2022

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“…A management strategy of KS associated with AIDS is limited to HAART, given that 50% of tumours are potentially regressing under this treatment [15]. Treatment options for the dermatological lesions of KS are surgical excision and curettage, CO 2 laser therapy and cryosurgery, silver nitrate cauterization, intralesional injections with vincristine, bleomicine, α-interferon, and other topical applications of imiquimod or alitretinoin [16]. Electrochemotherapy, brachytherapy with high radiation doses and low voltage photonic radiation can also be used for superficial lesions, while local radiotherapy is recommended for deeper skin lesions [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Treatment options for the dermatological lesions of KS are surgical excision and curettage, CO 2 laser therapy and cryosurgery, silver nitrate cauterization, intralesional injections with vincristine, bleomicine, α-interferon, and other topical applications of imiquimod or alitretinoin [16]. Electrochemotherapy, brachytherapy with high radiation doses and low voltage photonic radiation can also be used for superficial lesions, while local radiotherapy is recommended for deeper skin lesions [15,16]. Systemic or extended forms benefit from the administration of liposomal doxorubicin as first-line therapy or second-line paclitaxel [16].…”

Section: Introductionmentioning

confidence: 99%

“…Electrochemotherapy, brachytherapy with high radiation doses and low voltage photonic radiation can also be used for superficial lesions, while local radiotherapy is recommended for deeper skin lesions [15,16]. Systemic or extended forms benefit from the administration of liposomal doxorubicin as first-line therapy or second-line paclitaxel [16]. Interferon alfa continues to be used for its antiviral, antiangiogenic, antiproliferative and immunomodulatory properties [17].…”

Section: Introductionmentioning

confidence: 99%

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AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania

Arbune

Padurariu-Covit

Rebegea

et al. 2021

JCM

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Kaposi’s sarcoma (KS) was peculiarly described in the first notified cases of the acquired immunodeficiency syndrome as an opportunistic condition. However, the medical progress and the development of active antiretroviral therapy allowed the control of the HIV/AIDS epidemic, although the features of KS have changed throughout the past decades. The purpose of our study is to assess the epidemiological and clinical features of AIDS related KS in Romanian patients. A retrospective follow-up study was achieved in a single infectious diseases’ clinic from Galati—Romania, between 2001 and 2021. Referring to 290 new HIV diagnosed cases from our clinic retained in care, the prevalence of KS was 3.4%. The main characteristics of patients with KS are a median age of 33, a predominance of males, prevalent severe systemic forms of diseases, frequent association of past or concomitant tuberculosis, and context of immune reconstruction syndrome. The mortality rate was 70%. KS has occurred in patients with delayed HIV diagnoses and inadequate adherence to therapy. Early recognition of both infections, the close monitoring of latent or symptomatic tuberculosis, improving the antiretroviral adherence and raising the access to oncologic procedures in Romanian HIV patients could improve their prognosis related to KS.

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“…The former can either be adopted alone for localized lesions or combined with the latter in disseminated KS. 2 …”

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confidence: 99%

Reply to “Successful treatment of nodular human immunodeficiency virus–associated Kaposi sarcoma of the foot utilizing combination intralesional bleomycin and cryotherapy.”

Maronese

Tourlaki²,

Marletta

et al. 2022

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Diagnosis and treatment of classic and iatrogenic Kaposi's sarcoma: Italian recommendations

Cited by 22 publications

References 79 publications

Effectiveness and Safety of Treatment with Neodymium:YAG Laser 1064 nm in Patients with Classic and Epidemic Kaposi Sarcoma

Effectiveness and Safety of Treatment with Neodymium:YAG Laser 1064 nm in Patients with Classic and Epidemic Kaposi Sarcoma

AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania

Reply to “Successful treatment of nodular human immunodeficiency virus–associated Kaposi sarcoma of the foot utilizing combination intralesional bleomycin and cryotherapy.”

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