2016
DOI: 10.1016/j.bjhh.2016.07.004
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Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia

Abstract: Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) established by physical examination and blood counts, as well as by several biological and genetic markers. In t… Show more

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Cited by 33 publications
(29 citation statements)
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References 107 publications
(92 reference statements)
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“…Use of regimens with low evidence of benefit, such as CHOP, CVP or chlorambucil monotherapy, was observed in a significant proportion of patients (45%).Finally, the registry is also intended to promote greater scientific integration. The Brazilian Group of CLL (GBLLC) was created in 2013, with periodic meetings, recruitment for clinical trials and publication of recommendations for CLL diagnosis and treatment 8. Cooperative efforts in Brazil and other developing countries are in need for a more representative scenario of CLL, and the adequate assessment of epidemiology, outcomes and unmet needs in diagnosis, prognostic evaluation and treatment.…”
mentioning
confidence: 99%
“…Use of regimens with low evidence of benefit, such as CHOP, CVP or chlorambucil monotherapy, was observed in a significant proportion of patients (45%).Finally, the registry is also intended to promote greater scientific integration. The Brazilian Group of CLL (GBLLC) was created in 2013, with periodic meetings, recruitment for clinical trials and publication of recommendations for CLL diagnosis and treatment 8. Cooperative efforts in Brazil and other developing countries are in need for a more representative scenario of CLL, and the adequate assessment of epidemiology, outcomes and unmet needs in diagnosis, prognostic evaluation and treatment.…”
mentioning
confidence: 99%
“…Apesar de ibrutinibe não fazer parte do rol da Agência Nacional de Saúde Suplementar (ANS) (Ministério da Saúde -Brasil, 2016b), essa opção terapêutica foi adicionada à análise por se tratar de uma alternativa de segunda linha nas diretrizes (Hallek, 2015;Rodrigues et al, 2016) seguidas pela metodologia deste estudo.…”
Section: Discussionunclassified
“…As linhas de tratamento consideradas na análise foram adotadas de acordo com as condutas e diretrizes de tratamento para as terapias subsequentes pós-progressão, baseadas nas recomendações do GBLLC (Rodrigues et al, 2016) e o protocolo médico alemão de LLC publicado por Hallek, em 2015(Hallek, 2015. Vale ressaltar que as opções terapêu-ticas e as condutas médicas apresentadas foram adaptadas à realidade do mercado brasileiro.…”
Section: Métodosunclassified
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