Diagnosis and Treatment of Adult-Onset Still’s Disease

Abstract

Adult-onset Still’s disease (AOSD) is an obscure disease that is usually diagnosed after the exclusion of other febrile diseases, including other autoimmune, infectious, and malignant diseases. Although definitive diagnostic criteria and treatment guidelines for AOSD are thus far lacking, the typical manifestations of AOSD have been identified and effective medications for remission and maintenance have been proposed. The pathophysiology of the AOSD is unclear, but diagnostic criteria and treatment guidelines for AOSD can be established by determining its core etiology and conducting clinical trials of previously tested immunosuppressants and biologics.

Adult-onset Still's disease in clinical practice of infectious diseases: A case report

“…Kao faktori rizika navode se genetski (HLA DRB1*1201 i 1501, B35, DR2 i DR5), bakterijske i virusne infekcije (3), poremećaji imunološkog sistema, stres (1,5). Smatra se da je reč o autoimunom oboljenju u kojem neidentifikovani okidač pokreće imunološku kaskadu sa oslobađanjem proinflamatornih citokina, koji prouzrokuju sistemski zapaljenski odgovor (1,6). Laboratorijski testovi indikativni za dijagnozu jesu anemija, leukocitoza, LDH, sedimentacija eritrocita, CRP.…”

“…Laboratorijski testovi indikativni za dijagnozu jesu anemija, leukocitoza, LDH, sedimentacija eritrocita, CRP. Hiperferitinemija je često prisutna u ovom oboljenju pa se čak i predlaže praćenje nivoa feritina kao markera terapijskog odgovora (3,4,6).…”

Bibliometrics analysis on the research status and trends of adult-onset Still’s disease: 1921-2021

“…In the past few years, a number of scholars have carried out basic and clinical studies on the pathogenesis and treatment of AOSD ( 36 ). However, few reports have analyzed the characteristics and development trend of the AOSD over a long period of time, which is not conducive for researchers to accurately grasp the occurrence, development rules and characteristics of the AOSD ( 37 ).…”