Diagnosis and treatment guide for autoimmune hepatitis in Japan, 2013

森一, 恩地; 幹男, 銭谷; 和秀, 山本; 博仁, 坪内

doi:10.2957/kanzo.54.723

Cited by 10 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2013, the Ministry of Health, Labor, and Welfare's "Research on intractable liver and biliary diseases" group revised the AIH diagnostic guidelines. 17 In 2021, the diagnostic criteria is minor changed (Table 2). The genetic background, clinical presentation, and treatment responsiveness of AIH differ to a certain degree between races.…”

Section: Eases" Groupmentioning

confidence: 99%

“…16 In 2013, diagnostic and therapeutic guidelines for AIH were revised based on a nationwide survey conducted in 2009 and the latest research findings. 17 In 1993, the International Autoimmune Hepatitis Group (IAIHG) proposed an international descriptive criteria and a scoring system, 18 which were revised in 1999. 18,19 In 2008, the group proposed simplified international diagnostic criteria that were more in line with everyday medical practice.…”

Section: Introductionmentioning

confidence: 99%

“…Diagnostic criteria for AIH were formulated in 1996 16 . In 2013, diagnostic and therapeutic guidelines for AIH were revised based on a nationwide survey conducted in 2009 and the latest research findings 17 . In 1993, the International Autoimmune Hepatitis Group (IAIHG) proposed an international descriptive criteria and a scoring system, 18 which were revised in 1999 18,19 .…”

Section: Disease Concept and Introduced Changesmentioning

confidence: 99%

See 2 more Smart Citations

Clinical practice guidelines for autoimmune hepatitis

Ohira

Takahashi

Zeniya

et al. 2022

Hepatology Research

Self Cite

View full text Add to dashboard Cite

Section: Eases" Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Disease Concept and Introduced Changesmentioning

confidence: 99%

See 1 more Smart Citation

Clinical practice guidelines for autoimmune hepatitis

Ohira

Takahashi

Zeniya

et al. 2022

Hepatology Research

Self Cite

View full text Add to dashboard Cite

“…Due to severe hepatitis (10) (PT <60%, ALT >200 U/L, T.Bil >5 mg/dL), oral PSL 50 mg/day (1 mg/kg/day) was initiated from the 7th day of hospitalization. PSL was reduced to 40 mg/day 7 days after the initiation.…”

Section: Case Reportmentioning

confidence: 99%

Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate

et al. 2019

View full text Add to dashboard Cite

We herein report the first case of immune-mediated drug-induced liver injury that may have been caused by laninamivir. A 15-year-old girl was diagnosed with influenza and prescribed 40 mg laninamivir. Six weeks later, she was admitted to our hospital because of jaundice and fatigue. Laboratory examinations revealed elevated levels of hepatobiliary enzymes, and acute liver injury was suspected. Laboratory examinations and histological findings were characteristic of autoimmune hepatitis. Steroid treatment was ineffective, and azathioprine was added to the treatment. Twenty-two months after the onset, a second biopsy revealed the absence of inflammatory infiltrations, and the drugs were withdrawn. Liver function tests remained normal nine months after withdrawal.

show abstract

“…The current diagnostic criteria set a strict limit on AIH cases showing chronic active hepatitis with distinctive hepatitic activity. The classical AIH criteria of the Intractable Hepatobiliary Disease Study Group in Japan (2013) include the following: (i) exclusion of other causes of liver disease; (ii) positivity for anti‐nuclear antibody (ANA) and/or anti‐smooth muscle antibody; (iii) increased immunoglobulin G (IgG) level (>1.10 times the upper normal limit); (iv) interface hepatitis and plasma cell infiltration in liver tissues; and (v) marked efficacy of steroid therapy. Typical AIH is defined by the presence of (i) and any three items among (ii)–(v), whereas atypical AIH is defined by (i) and any one or two items among (ii)–(v).…”

Section: Classical Chronic Aihmentioning

confidence: 99%

Challenges and difficulties in pathological diagnosis of autoimmune hepatitis

Harada

Canh

Ohira

2017

Hepatology Research

View full text Add to dashboard Cite

Autoimmune hepatitis (AIH) with acute presentation is widely recognized as a distinct clinical entity, and its clinicopathology has been extensively studied. In most cases, AIH with acute presentation is merely acute exacerbation of classical chronic AIH, but pure acute-onset AIH without previous symptoms of chronic liver disease is also encountered. Rapid diagnosis and initiation of immunosuppressive treatment are necessary for both acute exacerbation and acute-onset to prevent fatal liver failure. The diagnostic criteria commonly used for classical AIH are generally applicable to acute exacerbation, but acute-onset AIH may present with additional pathological features. These features include an acute hepatitis phase characterized by centrilobular necrosis. However, centrilobular necrosis is also a feature of drug-induced liver injury, and there are no known histological characteristics exclusive to acute-onset AIH. Moreover, the possibilities of drug-induced AIH and immune-mediated drug-induced liver injury make diagnosis even more difficult. At present, liver biopsy is mandatory for the diagnosis of AIH with acute presentation, but careful consideration of all clinicopathological signs is necessary for differential diagnosis.

show abstract

Diagnosis and treatment guide for autoimmune hepatitis in Japan, 2013

Cited by 10 publications

References 0 publications

Clinical practice guidelines for autoimmune hepatitis

Clinical practice guidelines for autoimmune hepatitis

Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate

Challenges and difficulties in pathological diagnosis of autoimmune hepatitis

Contact Info

Product

Resources

About