Diagnosis and surgical treatment of carotid body tumor: A retrospective analysis of 58 patients

Hua, Qingquan; Xu, Zhihua; Jiang, Yang

doi:10.3892/ol.2017.6582

Cited by 17 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently DOTA coupled peptides PET/CT is required for further evaluation and the diagnosis is inferred based on the extent of somatostatin receptor uptake 2 . Preoperative biopsy is technically challenging because of risk of adrenergic crisis and excessive bleeding in HNPGL 3 …”

Section: Introductionmentioning

confidence: 99%

Dynamic contrast‐enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma

et al. 2021

View full text Add to dashboard Cite

Background and Purpose Morphological assessment with conventional magnetic resonance imaging (MRI) sequences has limited specificity to distinguish between paragangliomas and schwannomas. Assessing the differences in microvascular properties through pharmacokinetic parameters of dynamic contrast‐enhanced (DCE)‐MRI can provide additional information to aid in this differentiation. Materials and Methods A prospective study on MR characterization of neck masses was performed between January 2017 and March 2019 in our department, out of which 40 patients with head and neck paragangliomas (HNPGLs) (33 lesions) and schwannomas (15 lesions) were included in this analysis. MR perfusion using dynamic axial T1WI fat suppressed fast spoiled gradient recalled sequence with parallel imaging was performed in all the patients, in addition to single‐shot turbo spin‐echo axial diffusion weighted imaging (DWI) and routine MRI. ROI‐based method was used to obtain signal‐time curves, permeability measurements, and mean apparent diffusion coefficient (ADC) to differentiate paragangliomas from schwannomas. Statistical analysis was done to assess the significance and establish a cutoff to distinguish between the two entities. The available images of DOTANOC PET/CT (34 lesions) were analyzed retrospectively. Correlations between the perfusion, diffusion, and molecular PET/CT parameters were done. Results Paragangliomas had a higher wash‐in rate, wash‐out rate, Ktrans, Kep, and Vp (p < 0.001); while schwannomas had a higher relative enhancement (p < 0.012), time to peak, time of onset, brevity of enhancement, and Ve (p < 0.001). Among the perfusion parameters, Kep (area under curve (AUC) 0.994) and Vp (AUC 0.992) were found to have the highest diagnostic value. In diffusion‐weighted imaging, paragangliomas had a lower mean ADC compared to schwannomas (p < 0.001). The SUVmax and SUVmean were significantly associated with Ktrans, Kep, and Vp in paragangliomas. Conclusion DCE‐MRI in addition to DWI‐MRI can accurately distinguish HNPGL from schwannoma and may replace the need for any additional imaging and preoperative biopsy in most cases.

show abstract

Section: Introductionmentioning

confidence: 99%

Dynamic contrast‐enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Splaying of the internal and external carotid arteries and causing a lyre-like appearance is a feature indicating CBT. Besides the invasive nature, ectopic embolism, vascular ruptures and a high prevalence of cardiac arrest during angiographic assessment of CBTs were previously reported (15,16). Before MRI and CT can be performed, thorough protocols need to be evaluated respecting potential comorbidities of the patients like renal impairment, thyroid gland disbalances, allergic reactions to contrast media in order to safeguard appropriate scans.…”

Section: Introductionmentioning

confidence: 99%

Single-center study: dynamic contrast-enhanced ultrasound in the diagnostic assessment of carotid body tumors

Schwarze

Marschner

Figueiredo

et al. 2020

Quant Imaging Med Surg

View full text Add to dashboard Cite

Background: Carotid body tumors (CBTs) depict the most common paraganglioma of the head and neck that can metastasize in up to 15% of cases. They develop either sporadically or hereditarily and may produce catecholamines ("functioning CBTs") resulting in associated symptoms like headache, palpitations or flush.Non-functioning CBTs usually present as slowly and often tender growing mass which may affect adjacent cranial nerves. CBTs can be visualized by ultrasound, CT, MRI or angiography. Pre-surgical interventional embolization, surgical resection and radiation therapy are therapeutical options. The aim of this retrospective single-center study is to assess the safe and real-time evaluation of CBTs by contrast-enhanced ultrasound (CEUS).Methods: Ten patients with CBT were included in this study on whom CEUS was performed between 2007-2018 (mean age: 62 years). In 6/10 patients, results were confirmed by MRI, 4/12 patients underwent subsequent angiography. CEUS was performed and interpreted by a single consultant radiologist with experience since 2000 (EFSUMB level 3). VueBox ® software was used for standardized perfusion quantification.Results: CEUS allowed to detect all CBTs and visualize intratumoral microcirculation. Perfusion quantification was performed in 6/10 cases. CBTs showed significantly reduced peak-enhancement (PE), reduced wash-in perfusion index (WiPI) and significantly elevated time to peak (TTP) compared to common carotid arteries (CCA).Conclusions: CEUS is a useful and safe tool for identifying CBTs and evaluating intratumoral microperfusion at high spatial and temporal resolutions in real-time. In addition to conventional ultrasound, CT, MRI and digital substraction angiography (DSA), CEUS may be implemented in the future diagnostic work-up and follow-up of CBT patients.

show abstract

“…Furthermore, a functioning paraganglioma requires preprocedural treatment with an a-blocker to avoid hypertensive crisis. 3,4 Occasionally schwannomas can mimic paragangliomas on conventional cross-sectional imaging. [3][4][5] Digital subtraction angiography (DSA) remains the gold standard technique to differentiate between the two entities; however, the procedure itself carries a 1-2% increased risk of stroke.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Occasionally schwannomas can mimic paragangliomas on conventional cross-sectional imaging. [3][4][5] Digital subtraction angiography (DSA) remains the gold standard technique to differentiate between the two entities; however, the procedure itself carries a 1-2% increased risk of stroke. 6 We aim to explore the potential role of the enhancement pattern on neck computed tomography angiography (CTA) in differentiating paragangliomas from schwannomas.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Computed tomography angiography lightbulb sign: Characteristic enhancement pattern on neck computed tomography angiography in differentiating paraganglioma from schwannoma of the carotid space

Suthiphosuwan

Bai

et al. 2020

Neuroradiol J

View full text Add to dashboard Cite

It is important to correctly distinguish paragangliomas from other tumors such as schwannomas in the preoperative assessment of head and neck tumors because paragangliomas have a propensity to bleed profusely during surgery. Therefore, preoperative embolization is often required while with schwannomas preoperative embolization is generally not required. Occasionally, schwannomas can mimic paragangliomas on routine computed tomography and magnetic resonance imaging of the neck. In this study, we retrospectively evaluated the computed tomography angiography of the neck of 10 patients with carotid space tumors. Seven patients had pathologically proven paraganglioma while three patients had schwannomas. We describe the “computed tomography angiography lightbulb sign” as avid homogeneous enhancement in the arterial phase which can accurately distinguish these entities.

show abstract

Diagnosis and surgical treatment of carotid body tumor: A retrospective analysis of 58 patients

Cited by 17 publications

References 16 publications

Dynamic contrast‐enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma

Dynamic contrast‐enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma

Single-center study: dynamic contrast-enhanced ultrasound in the diagnostic assessment of carotid body tumors

Computed tomography angiography lightbulb sign: Characteristic enhancement pattern on neck computed tomography angiography in differentiating paraganglioma from schwannoma of the carotid space

Contact Info

Product

Resources

About