Diagnosis and significance of cystic hygroma in the first trimester

Cullen, Mark T.; Gabrielli, S.; Green, Jacqueline J.; Rizzo, Nicola; Mahoney, Maurice J.; Salafia, Carolyn; Bovicelli, Luciano; Hobbins, John C.

doi:10.1002/pd.1970101004

Cited by 110 publications

(71 citation statements)

References 24 publications

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“…[13] diagnosed cervical cysts above 2.5-3 mm in diameter as cystic hygroma, we used a discriminatory diameter of 5 mm to avoid any pitfalls and to differentiate between pathological and physiological variation [4,8,14,15]. Another cause might be due to the fact that cases with chromosomal aberrations, which were generally terminated in other studies [5,12,13], were conservatively observed without any intervention in our study.…”

Section: Discussionmentioning

confidence: 99%

“…According to Bronshtein et al [13], non-septated hygroma may represent a temporary accumulation of lymph due to incomplete obstruction of lymphatic drainage and actually most of the non-septated hygroma in their report were transient, indicating that a lack of septation might not be a pathological situation. Cullen et al [4], Shulman et al [5] and Brumfield et al [19], on the other hand, concluded that it is useless to evaluate septation in the prediction of fetal prognosis. Our results coincide with the latter.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of fetal cystic hygroma was made based on transabdominal ultrasonographic findings (Toshiba SSA-270, Tokyo, Japan and Aloka SSD-5000, Tokyo, Japan, with a 3.5-or 5-MHz convex transducer) in which a cystic lesion of 1 5 mm was found in the neck of the fetus with an intact skull and spinal column [4,8].…”

Section: Methodsmentioning

confidence: 99%

“…Although there are a few reports concerning intrauterine treatment of cystic hygroma, the acceptable indication of intrauterine treatment has not yet been established [3]. On the other hand, several investigators have reported that there are some cases of live birth after spontaneous resolution of the cystic lesion [4][5][6]. The long-term prognosis of living infants remains to be clarified [7].…”

Section: Introductionmentioning

confidence: 99%

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In utero Evaluation and the Long-Term Prognosis of Living Infants with Cystic Hygroma

Fujita¹,

Shoji²,

Nakayama³

et al. 2001

Fetal Diagn Ther

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Objective: The aim is to evaluate the natural course and the long-term prognosis of cystic hygroma following live birth. Methods: Of 39 cases, 12 were excluded because of either artificial termination or intrauterine treatment. 27 cases were retrospectively classified into 2 groups based on the outcome, and the clinical profiles were compared. The long-term prognosis was analyzed for live births. Results: 5 (18.5%) and 22 (81.5%) cases resulted in live birth and fetal demise, respectively. Both the frequency of hydrops fetalis and the maximum size of the cyst were more significantly associated with a poor prognosis (p < 0.01). Of 5 live births, 3 cases with chromosomal or structural abnormalities were handicapped. Conclusions: Hydrops fetalis and cyst size are poor prognostic factors, and fetal chromosome and structural malformations should be taken into account when predicting the long-term prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In utero Evaluation and the Long-Term Prognosis of Living Infants with Cystic Hygroma

Fujita¹,

Shoji²,

Nakayama³

et al. 2001

Fetal Diagn Ther

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“…A partir do início da década de 1990, vários trabalhos associaram a presença de uma quantidade anormal de fluido na região da nuca fetal, no primeiro trimestre da gestação [translucência nucal (TN) aumentada], com um aumento do risco de cromossomopatias [1][2][3][4][5][6][7][8] . Diferentes mecanismos fisiopatológicos foram propostos para explicar uma TN aumentada no fim do primeiro trimestre da gestação, entre eles as disfunções cardíacas, as anormalidades na matriz extracelular, o desenvolvimento anormal do sistema linfático, as limitações dos movimentos fetais, a anemia fetal ou a hipoproteinemia e as infecções fetais 5,9,10 .…”

Section: Introductionunclassified

Evolução perinatal e pediátrica de crianças com translucência nucal aumentada e cariótipo normal

Vieira¹,

Silva²,

Faria³

et al. 2013

Rev. Bras. Ginecol. Obstet.

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(45,6%). Nos fetos com cariótipo normal, houve um abortamento na 15ª semana gestacional com pentalogia de Cantrel, um óbito na 24ª semana com diversas anomalias estruturais, um óbito neonatal sem causa definida e dois casos de comunicação intraventricular (CIV) detectados no ECO fetal. Na avaliação ecocardiográfica pós-natal, persistiu um caso de CIV e foi diagnosticado um caso de comunicação interatrial (CIA) e persistência do canal arterial (PCA). Entre os 40 casos sobreviventes, apenas 1 criança apresentou atraso no desenvolvimento da fala e outra apresentou quadro de autismo. Os demais casos resultaram em desenvolvimento neuropsicomotor normal. CONCLUSÃO: No acompanhamento dos fetos com TN aumentada e cariótipo normal, os pais podem ser mais bem aconselhados de que, frente a um exame morfológico-ecocardiográfico do 2° trimestre sem alterações, a probabilidade de a criança nascer viva e bem é alta (93,5%). Abstract PURPOSE:To analyze the perinatal and pediatric outcome of fetuses that showed nuchal translucency (NT) above the 95th percentile (P95) and a normal karyotype in order to obtain data allowing better maternal prenatal counseling. METHODS: fetuses from a tertiary obstetric service with an NT above P95 and a normal karyotype were analyzed between 2005 and 2011. We analyzed gestational ultrasound follow-up, fetal and postnatal echocardiography (ECHO), weight, length and Apgar score at birth, and neuropsychomotor development by the Ages and Stages Questionnaire (ASQ) up to July 2012. RESULTS: During this period, there were 116 cases of nuchal translucency above the 95th percentile, and the fetal karyotype was determined in 79 of them (68%). Forty-three analyses were normal (54.4%) and 36 were altered (45.6%). Among the fetuses with a normal karyotype, one was miscarried at 15 weeks of gestation with Cantrel pentalogy and one died at 24 weeks with several structural abnormalities. There was one neonatal death of unknown cause and two cases of intraventricular communication (IVC) detected by fetal ECHO. Postnatal echocardiography revealed the persistence of IVC in one case and one case of atrial septal defect (ASD) and patent ductus arteriosus (PDA). Of the 40 surviving children, only 1 showed delayed speech development and another presented autism. The remaining cases resulted in normal neurodevelopment. CONCLUSION: During the monitoring of fetuses with increased NT and a normal karyotype, parents can be best advised that when a 2 nd trimester morphologicalechocardiography ultrasound study is normal, the probability of the child being born alive and well is high (93.5%).

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Prenatal Detection of Two Different Monosomic Cell Lines by Chorionic Villus Sampling

et al. 1996

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Diagnosis and significance of cystic hygroma in the first trimester

Cited by 110 publications

References 24 publications

In utero Evaluation and the Long-Term Prognosis of Living Infants with Cystic Hygroma

In utero Evaluation and the Long-Term Prognosis of Living Infants with Cystic Hygroma

Evolução perinatal e pediátrica de crianças com translucência nucal aumentada e cariótipo normal

Prenatal Detection of Two Different Monosomic Cell Lines by Chorionic Villus Sampling

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