Diagnosis and Outcome of Small Bowel Tumors Found by Capsule Endoscopy: A Three-Center Australian Experience

Abstract

Small bowel tumors are a significant finding at CE and are often missed by other methods of investigation. In many patients, detection of a tumor alters management and improves outcome. Even in malignant lesions, treatment is potentially curative in the absence of metastatic disease.

Clinical Characteristics of Small Bowel Tumors Diagnosed by Double-Balloon Endoscopy: KASID Multi-Center Study

“…The mean age of patients with small bowel tumors was 47.1 years, which was lessened by the patients with benign polyps such as Peutz-Jeghers polyps, and the mean age of patients with GISTs/leiomyomata, lymphomas, or adenocarcinomas was above 50 years. Although the mean age of the patients with small bowel tumors was above 60 years in several CE studies [4][5][6][7][8][9][10], the mean age of those patients with small bowel tumors was 53 years in a Japanese DBE study [17], which is comparable with our results. The disagreement is not thought to be because of racial difference but because of the difference of the mean age between patients who received CE and patients who underwent DBE.…”

“…In the past, the diagnosis of small bowel tumors was made mainly through SBFT, abdominal CT, or even laparotomy; however, more accurate diagnosis for small bowel tumors became possible after the development of CE and DBE. The frequency of small bowel tumors in patients who receive CE has been reported to be 1.6-8.9% [4][5][6][7][8][9][10], while the frequency in patients who receive DBE is 10.0, 11.5 and 13.9% according to studies performed in Germany, Portugal, and Japan, respectively [15][16][17]. This difference is because DBE is usually performed to confirm abnormal findings that have been detected by other imaging studies, including CE.…”

“…Although CE is superior to DBE in terms of non-invasiveness and convenience for total enteroscopy, its usefulness is occasionally limited by capsule retention. The incidence of capsule retention can reach 9.7-25% in patients with small bowel tumors [8][9][10], which is much higher than the incidence in all patients receiving CE and even higher than that in patients with small bowel Crohn's disease. Additionally, false positive or false negative findings are frequently observed during CE.…”

“…Although it is a minimally invasive test, capsule endoscopy enables the diagnosis of various disorders of the small intestine, such as vascular abnormalities, ulcerative lesions, and tumors [4][5][6][7][8][9][10]. However, false positive or false negative results for small bowel tumors are limitations of capsule endoscopy [11][12][13], and capsule retention occasionally occurs.…”

Capsule Endoscopy: A Comprehensive Review

“…(Ciresi & Scholten, 1995;DiSario et al, 1994;Lewis, 1994;Lewis et al, 2005;Kariv & Arber 2003). Early clinical studies of CE have reported a frequency of SB tumors ranging between 6% and 9% (Bailey et al,2006;Cobrin et al,2006;de Franchis et al,2004;Estevez et al,2007;Schwartz &Barkin,2007;Urbain et al,2006). This has led to an idea that CE doubled the rate of diagnosing SB tumors.…”