Diagnosis and management of Stage 1A (microinvasive) carcinoma of the cervix

Boutselis, John G.; Ullery, John C.; Charme, Lawrence

doi:10.1016/0002-9378(71)90553-9

Cited by 28 publications

(6 citation statements)

References 10 publications

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“…At the same time, there has been no agreement on the limit of the depth of invasion with advocates for 1 (5) , 3 (6–8) , 4 (9) , 5 (10–15) , and 9 mm (16) . Moreover there is disagreement on the point from which this should be measured.…”

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confidence: 97%

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Early invasive (FIGO stage IA) carcinoma of the cervix: a clinico-pathologic study of 476 cases

Elliott¹,

Coppleson²,

Russell³

et al. 2000

Int J Gynecol Cancer

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The clinical and histologic features of 476 tumors fitting the 1995 FIGO definition of stage IA cervical cancer, treated at a Sydney tertiary referral hospital between 1953 and 1992, are reviewed. Five-year follow-up was complete with a median of 10 years. The diagnosis was increasingly made by histologic examination of colposcopically directed cone biopsy. The majority (88%) of tumors were squamous. The proportion of both younger women (3 mm. Treatment was surgical in 99% and was increasingly more conservative as the study progressed with no apparent increase in treatment failure. From 1973 treatment by cone biopsy rose from 6.5 to 35%, by radical hysterectomy fell from 51 to 21% and by lymphadenectomy from 53 to 26%. Only one of 115 patients treated by cone biopsy died. Positive lymph nodes were detected in 1.7% of 180 patients undergoing lymphadenectomy. There were 16 recurrences (3.4%); six vaginal with no cancer deaths, nine pelvic and one distant, with nine deaths and three new cancers (two deaths). Univariate analysis suggests that older age, glandular tumors and those invading 3 mm were associated with more treatment failures and multivariate analysis showed that both conservative hysterectomy and the omission of lymphadenectomy are associated with higher recurrence rates with >3 mm invasion. The study failed to resolve the dilemma of predicting those tumors with a poor prognosis.

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confidence: 97%

“…Moreover there is disagreement on the point from which this should be measured. The most frequently favored are the epithelial surface (9,12–14,17–19) and the basement membrane (7,20–23) but commonly the method used has been neither recorded nor reported.…”

mentioning

confidence: 99%

Early invasive (FIGO stage IA) carcinoma of the cervix: a clinico-pathologic study of 476 cases

Elliott¹,

Coppleson²,

Russell³

et al. 2000

Int J Gynecol Cancer

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“…Averette mm. Sedlis et al (7) reported that many residual lesions were observed after conization in Ia1 cases with vessel permeation, and Boutselis et al (8) advised the practice of hysterectomy and lymphadenectomy.…”

Section: Discussionmentioning

confidence: 99%

Pathological indications for conservative therapy in treating cervical cancer

Okamoto¹,

Ueki²,

Ueki³

1999

Acta Obstet Gynecol Scand

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“…Wharton et a!28reviewed their experience with micro invasive carcinoma of the vulva in an at tempt to answer this question. In a study of 25 patients with lesions smaller than two cm in diameter and with five mm or less of stromal invasion, they found neither posi tive lymph nodes in 10 patients who had lymphadenectomy nor any deaths due to cancer in the entire series. Wharton et al concluded from this that microinvasive car cinoma of the vulva is a definable stage and that this group of patients may be treated by conservative surgery consisting of radi cal vulvectomy alone.…”

Section: Vulvar Cancermentioning

confidence: 96%

Conservative Management Of the Patient with Early Gynecologic Cancer

DiSaia¹

1989

CA: A Cancer Journal for Clinicians

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Diagnosis and management of Stage 1A (microinvasive) carcinoma of the cervix

Cited by 28 publications

References 10 publications

Early invasive (FIGO stage IA) carcinoma of the cervix: a clinico-pathologic study of 476 cases

Early invasive (FIGO stage IA) carcinoma of the cervix: a clinico-pathologic study of 476 cases

Pathological indications for conservative therapy in treating cervical cancer

Conservative Management Of the Patient with Early Gynecologic Cancer

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