Diagnosis and Management of Sepsis and Septic Shock: An Evidence-Based Review

Tulli, G

doi:10.1007/978-3-319-94189-9_9

Cited by 2 publications

(2 citation statements)

References 114 publications

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“…Complement activation by COVID-19 is another leading theory regarding the mechanism of aHUS precipitated by COVID-19. For example, one case report detailed the findings that lung and skin tissue of patients with severe COVID-19 infection with either respiratory failure or purpuric skin rash had substantial deposits of complement cascade proteins within the microvasculature, suggesting a systemic activation of the complement pathways by COVID-19 [ 13 ]. Lastly, recent evidence suggests the spike protein may directly activate the alternative complement pathway [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reports

et al. 2021

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Background Atypical hemolytic uremic syndrome is an exceedingly rare thrombotic microangiopathy caused by accelerated activation of the alternative complement pathway. Case presentation Here, we report two cases of patients presenting with suspected atypical hemolytic uremic syndrome precipitated by coronavirus disease 2019 infection. The first patient, a 25-year-old Hispanic male, had one prior episode of thrombotic microangiopathy presumed to be atypical hemolytic uremic syndrome precipitated by influenza A, and re-presented with thrombocytopenia, microangiopathic hemolytic anemia, nonoliguric renal failure, and normal ADAMTS13 activity, with confirmed coronavirus disease 2019 positivity. The second patient, a 31-year-old Caucasian female, had no personal history of thrombotic microangiopathy, though reported a family history of suspected atypical hemolytic uremic syndrome. She presented with similar laboratory derangements, oliguric renal failure requiring hemodialysis, and confirmed coronavirus disease 2019 positivity. Both patients were treated with eculizumab with complete resolution of their hematologic and renal complications. Conclusion To our knowledge, this represents the largest case series of atypical hemolytic uremic syndrome precipitated by coronavirus disease 2019 in adults.

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Section: Discussionmentioning

confidence: 99%

Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reports

et al. 2021

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“…Death rate extended to above half, with much higher death rates in sufferers with ischemic bowel, central nervous system (CNS) contamination, scattered disease, and another intra-stomach disease. two Somewhat decline death rates occur in those with obstructive uropathy-related urinary tract disease, enterocolitis/diverticulitis, pyelonephritis, cholecystitis/cholangitis, and intravascular catheter pollution (Tulli, 2019).…”

Section: Mortality Rate Of Sepsismentioning

confidence: 99%

Impact of Septic Bundle on Critically Ill Patients Outcomes: Scoping Review

Rehbeini¹

2020

TIJNR

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Objective: This review is aimed to evaluate the effect of implementing the septic bundle on critically ill patients’ outcomes. Methodology: Cochrane Collaboration, MEDLINE, CINAHL, EMBASE, Science Direct, Web of Science, Scopus and PubMed were searched, covering the period 2008 to 2019. Only cohort, case-control and randomized controlled trial studies with full text in English were eligible. Studies that discussed the effect of implementing the septic bundle on critically ill patients' outcomes were only included. Results: Out of 1,551 articles searched, and after screening inclusion and exclusion criteria; ten articles only were met the inclusion criteria which have considered the effect of implementing a septic bundle on critically ill patients’ outcomes. All of these ten studies revealed a significant effect of the septic bundle on the clinical outcomes of critically ill patients especially mortality. Conclusion: This review confirmed that implementing septic bundle for critically ill patients has been significantly reduced outcomes which are length of hospital stay, length of stay at emergency department, mortality probability, admission to the intensive care unit and mechanical ventilation.

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Diagnosis and Management of Sepsis and Septic Shock: An Evidence-Based Review

Cited by 2 publications

References 114 publications

Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reports

Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reports

Impact of Septic Bundle on Critically Ill Patients Outcomes: Scoping Review

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