Diagnosis and management of optic nerve glioma

Shapey, Jonathan; Danesh‐Meyer, Helen V.; Kaye, Andrew H.

doi:10.1016/j.jocn.2011.09.003

Cited by 76 publications

(70 citation statements)

References 90 publications

(118 reference statements)

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“…Составляя от 3 до 5% интракраниальных опухо-лей у детей и являясь, как правило, пилоидными астроцитомами, ГПЗП занимают 2-е место среди причин слепоты у пациентов с нейрохирургической патологией детского возраста. У взрослого контин-гента ГПЗП встречаются еще реже [1,2]. Считается, что у взрослых пациентов эти опухоли представлены обычно злокачественными астроцитомами или глио-бластомами [3].…”

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Chiasm and optic nerve glioma manifested as hemorrhage (two clinical cases and a literature review)

et al. 2016

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Chiasm and optic nerve glioma manifested as hemorrhage (two clinical cases and a literature review)

et al. 2016

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“…Chiasmal apoplexy rarely occurs in an optic glioma, but the frequency is unknown. Malignant optic gliomas of adulthood usually present with sudden acute visual loss in 70-84 % of patients [15]. The clinical symptoms and time courses of optic pathway CM and glioma often overlap.…”

Section: Epidemiology and Clinical Course Of Optic Pathway Cmsmentioning

confidence: 99%

“…The initial preoperative neuroimaging diagnosis was difficult to make, and CM was not suspected as the initial diagnosis in 34 % of patients [11]. In contrast, the typical MR imaging findings of optic glioma include an iso-to hypointense lesion on T1-weighted images, a hyperintense lesion on T2-weighted images, and homogeneous enhancement with Gd administration, although variable peripheral enhancement may be found with a central area of necrosis or cyst formation [3,15]. Chiasmal gliomas frequently demonstrate a variable contrast enhancement pattern and sometimes have suprasellar extension [5,14].…”

Section: Neuroimaging Findings Of Optic Pathway Cmsmentioning

confidence: 99%

“…If typical hemorrhagic findings are seen in the optic tract on MR imaging, CM should be considered in the differential diagnosis. However, if such typical neuroimaging findings are not obtained, CM is difficult to distinguish from optic glioma [3,11,15]. Fig.…”

Section: Neuroimaging Findings Of Optic Pathway Cmsmentioning

confidence: 99%

“…Historically, there has not been clear consensus over the role of biopsy at diagnosis and the start of therapy against optic pathway tumors, independent of NF1 status. If an optic glioma is highly suspected based on the MR imaging findings, that is included an iso-to hypointense lesion on T1-weighted images, a hyperintense lesion on T2-weighted images, and homogeneous enhancement or peripheral enhancement with Gd administration [3,15], because most optic gliomas are low-grade astrocytoma, biopsy or other surgical interventions are not recommended [18,20]. As recent trends, optic pathway tumors with these typical MR imaging findings as optic gliomas do not require biopsy or surgery, and initially, watch/wait/rescan policy should be adopted if the tumor is small and asymptomatic [3].…”

Section: Optimal Treatment Of Optic Pathway Cms and Management Of Optmentioning

confidence: 99%

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Cavernous malformation of the optic pathway mimicking optic glioma: a case report

et al. 2014

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Purpose Optic pathway cavernous malformations (CMs) are extremely rare, accounting for less than 1 % of all intracranial CMs. We report a case of optic pathway CM mimicking optic glioma because the initial magnetic resonance (MR) images did not disclose hemorrhagic findings such as popcorn-like lesion or hemosiderin ring. Methods A 20-year-old woman presented with subacute left visual acuity loss and visual field defect and was referred to our hospital. Initial MR imaging findings were suggestive of optic glioma. Second MR imaging demonstrated hemorrhagic findings, but the hemorrhage was considered to be intratumoral hemorrhage from left optic pilocytic astrocytoma. She underwent radiochemotherapy and intravenous administration of corticosteroids but her symptoms deteriorated. Third and fourth MR imaging revealed enlargement of the hematoma. Therefore, the radiation therapy was interrupted at a delivered dose of 16.2 Gy, and craniotomy was performed to preserve residual right visual field. The lesion was totally removed and the histological diagnosis was CM. Her right visual field was preserved, but not improved. Results The present case and previous cases suggest that optic pathway CMs sometimes do not initially manifest with signs of hemorrhage, so CMs should be included in the differential diagnosis of optic pathway lesions.Conclusions Histological confirmation with preparation for total resection should be considered for rapidly progressive cases even if the neuroimaging findings are compatible with optic glioma.

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