Diagnosis and Management of Neuropathic Pain

Abstract

A recent revision in the definition of neuropathic pain has highlighted this condition as a distinct disease entity. More accurate search for a lesion in the somatosensory nervous system as the pain-generating mechanism will help target the treatment by pharmacological agents. A multidisciplinary approach is recommended, with pharmacotherapy supplemented by psychological therapy and physical rehabilitation, and appropriate interventional treatment for selected refractory cases.

Go-sha-jinki-Gan (GJG) ameliorates allodynia in chronic constriction injury model mice via suppression of TNF-α expression in the spinal cord

“…7 To date, no ideal treatment for NP has been established. 9 In view of the above issues, the development of novel therapies for NP is highly anticipated.…”

Median Nerve Stimulation as a Nonpharmacological Approach to Bypass Analgesic Tolerance to Morphine: A Proof-of-Concept Study in Mice

“…O pioids are commonly prescribed for postoperative pain 77 or severe neuropathic pain. 75 However, many patients continue to consume opioids well after surgery 21 due to continued pain 18 or postsurgical opioid over-prescription. 5,40 Analgesic tolerance developing after repeated opioid consumption 7 further increases the risk of developing opioid dependence, withdrawal and/or overdose.…”

Consideraciones para el examen clínico del Síndrome de Opérculo Torácico neurogénico inespecífico

“…Esto puede ser complejo fuera del escenario de la Neurología, pero la literatura disponible ofrece herramientas para lograrlo. En ausencia de gold estándar para DN, la historia médica, una distribución neuroanatómicamente plausible del dolor, termoalgesia positiva y la aplicación de la escala LANSS orientan hacia un desorden del sistema somatosensorial como causante del dolor en una topografía típica (38). No siempre se tiene acceso a test diagnósticos objetivos para confirmar con certeza la lesión o enfermedad del sistema somatosensorial.…”