Diagnosis and management of malignant germ cell ovarian tumors in young females

Zalel, Yaron; Piura, Benjamin; Elchalal, Uriel; Czernobilsky, Bernard; S, Antebi; Dgani, R.

doi:10.1016/0020-7292(96)02719-1

Cited by 88 publications

(48 citation statements)

References 50 publications

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“…More studies are being done to assess the immunogenetics of such patients. This is interesting considering most tumours do not have racial bias [4].…”

Section: Discussionmentioning

confidence: 98%

Case Report on Acute Psychosis Due to Anti-NMDAR Encephalitis

S¹,

Karunajeewa²

2014

OJIM

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A 32-year-old female with depression on treatment, was presented with acute psychosis, behavioural symptoms, autonomic instability and a prodromal illness. This occurred on a background of a strong family history of schizophrenia. Despite escalating doses of anti-psychotics, she failed to improve. Her CSF showed a lymphocytic pleocytosis and confirmed the presence of anti-NMDAR antibodies. Following treatment with immunotherapy and excision of her underlying ovarian tumour, she showed a dramatic and seemingly full recovery of her psychotic symptoms. She was weaned off all medications with no residual symptoms. Clinician awareness is important to treat this uncommon but potentially reversible condition. KeywordsPsychosis; Ovarian Teratoma; Encephalitis Case PresentationA 32-year old woman with a previous history of depression and strong family history of schizophrenia was presented to a rural hospital with a three-day history of confusion, insomnia, agitation, auditory and visual hallucinations. She was initially diagnosed with acute psychosis and treated with olanzapine, quetiapine, sodium valproate and clonazepam. Ten days prior to presentation, she had a prodromal viral like illness with headaches and arthralgias treated as migraine with no improvement.This presentation was complicated by significant hemodynamic compromise (fever, hypotension and tachycardia), and she was transferred to our hospital due to concerns regarding neuroleptic malignant syndrome or an underlying meningo-encephalitic process.On examination, she had a temperature of 38.6˚C, sinus tachycardia (pulse = 130 b/min), hypotension (BP = 95/65 mmHg) and hyperreflexia but no meningeal signs. She displayed florid psychotic symptoms-including

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“…More studies are being done to assess the immunogenetics of such patients. This is interesting considering most tumours do not have racial bias [4].…”

Section: Discussionmentioning

confidence: 98%

Case Report on Acute Psychosis Due to Anti-NMDAR Encephalitis

S¹,

Karunajeewa²

2014

OJIM

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“…Ovarian germ cell tumors (OGCTs) arise primarily in young women between 10 and 30 years of age. 10 In a review of the literature on both mixed and pure primary choriocarcinoma of the ovary, the age range of the patients was seven months to 35 years with a mean of about 13 years. 11 Most ovarian choriocarcinomas are gestational in origin, and usually are metastases from uterine or tubal choriocarcinomas.…”

Section: Discussionmentioning

confidence: 99%

Primary Nongestational Choriocarcinoma of the Ovary

Alam¹,

Bhuiyan

Nabi

2014

J Enam Med Col

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“…Dysgerminoma was the most common malignant germ cell tumour followed by mixed germ cell tumours. (19) Leiomyomas were the common uterine tumours associated with pregnancy and their incidence during pregnancy was approximately 2%. (1) Leiomyomas vary in location and may develop as submucosal, subserosal, or intramural growths.…”

Section: Discussionmentioning

confidence: 99%