Diagnosis and management ofCandida utilisinfectious arthritis in a Standardbred filly

Abstract

Summary A 3‐year‐old Standardbred filly was admitted to the hospital for evaluation and management of previously diagnosed infectious arthritis of the right metacarpophalangeal joint (MCPJ). Candida utilis was isolated from multiple synovial samples submitted for bacterial culture and susceptibility. Following treatment with systemic and intra‐articular fluconazole and regional limb perfusion with amphotericin B and a second arthroscopic debridement the lameness improved and subsequent cultures were negative for bacterial or fungal growth. Infectious fungal arthritis should be a differential diagnosis for atypical or unresponsive joint infections especially in horses previously treated with a combination of intra‐articular corticosteroids and antibiotics.

Management of Candida guilliermondii joint infection in a dog

“…The importance of aseptic technique during intra-articular administration of glucocorticoids, in order to decrease the occurrence of secondary infection, has been documented [ 2 , 3 ]. Whilst reports of bacterial synovitis/arthritis in dogs are non-uncommon, reports on Candida-associated arthritis have apparently not been published yet, although fungal joint infections have been reported in horses [ 4 – 8 ]. The purpose of this case report is to document a successful treatment with a combination of joint lavage, systemic and local antifungal drugs of a solitary case of a Candida guilliermondii joint infection in a dog.…”

Clinical challenges of persistent articular sepsis

“…This post injection joint reaction is thought to be the result of Type 4, cell mediated hypersensitivity (Marino et al 2006;Tahiri et al 2007). Cohen et al (2008) are to be commended for thinking beyond the common clinical conditions, since fungal arthritis is uncommon, with only 4 published reports in the literature of fungal arthritis in horses (Reilly and Palmer 1994;Madison et al 1995;Swerczek et al 2001;Sherman et al 2006). Since infectious arthritis due to bacterial contamination is the most common clinical scenario, clinicians often fail to consider other potential aetiological agents.…”

“…In the majority of clinical cases, cost has some role as far as the limitations of treatment. There is no mention by Cohen et al (2008) of the cost for treatment of the horse. Based on a very rough and generally underestimated calculation, the treatment included: 2 general anaesthetic procedures with surgical treatment (~£1500/surgery), the various parenteral and regional antibiotic medication (£1500), bandage changes (45 at £25 = £1125), radiographs (£200) and 35 days of hospitalisation (£1000), giving a total cost of approximately £7000 ($14,000).…”

“…The case report by Cohen et al (2008) provides a useful review of the uncommon condition of fungal arthritis due to Candida utilis in the horse. The case details and the accompanying discussion provide the reader with a thorough review of the treatments for fungal arthritis.…”

Essential Oils Antagonism Against Three Hygiene Significant Yeasts and Juice Spoilage by Saccharomyces Cerevisiae

“…Current study objectives were designated in accordance with several studies who examined plants derived EOs for their various biological properties. EOs were tested as natural antimicrobial active agents in food sanitary[31][32][33][34][35][36][37][38] and as a natural therapeutic treatment of Candida and other dermatophyte infections[9,[18][19][20][21][22][23][24][25]. The antagonistic property detected for EOs from Pru.…”