Diagnosis and Management of Human Parvovirus B19 Infection

Ramírez, Mildred; Mastrobattista, Joan M.

doi:10.1016/j.clp.2005.04.003

Cited by 22 publications

(8 citation statements)

References 20 publications

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“…The seasonality of this study, during the period from 1993 to 1995, was similar to other studies, in other words, between late winter and spring (Cubel et al 1996, Ramirez & Mastrobatista 2005, although in 1996 the incidence was lower than in previous years, and there was no late winter/spring peak.…”

Section: Yearssupporting

confidence: 73%

Parvovirus B19 Frequency in Exanthematic Cases Initialy Suspected as Measles or Rubella Infections in São Paulo, Brazil

Oliveira¹,

Curti²,

Afonso³

et al. 2009

VR&R

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Parvovirus B19 infection may be misdiagnosed as measles, rubella, or other exanthematic diseases which are common in childhood. The clinical differential diagnosis for these infections can be misleading due to their similarity in most mild cases and the occurrence of atypical cases. In order to establish the occurrence of parvovirus B19 infection among children with exanthema, paired serum samples from 881 patients with presumptive diagnoses of measles or rubella were tested for IgM and IgG antibodies against parvovirus B19 through the ELISA capture method from 1993 to 1996, after being proved to be not measles or rubella infections. Parvovirus B 19 infection was confirmed in 80 individuals (9%) with IgM positive antibodies, and 240 (27%) with IgG positive antibodies. Sera positive for B19 corresponded to 1% of measles and 96% of rubella suspected cases. Therefore, parvovirus B19 should be considered for serological analysis when a child presents exanthema.

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Section: Yearssupporting

confidence: 73%

Parvovirus B19 Frequency in Exanthematic Cases Initialy Suspected as Measles or Rubella Infections in São Paulo, Brazil

Oliveira¹,

Curti²,

Afonso³

et al. 2009

VR&R

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“…The presence of IgM class antibodies suggests recent infection. IgM antibodies can be detected 10 to 14 days post infection and may persist for five months, and occasionally even longer [231]. IgG and IgM reach peak titers within one month.…”

Section: G Parvovirus (Erythrovirus) B19mentioning

confidence: 99%

A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2013 Recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)a

Baron

Miller

Weinstein

et al. 2013

Clinical Infectious Diseases

465

339

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The critical role of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician and the microbiologists who provide enormous value to the health care team. This document, developed by both laboratory and clinical experts, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. Sections are divided into anatomic systems, including Bloodstream Infections and Infections of the Cardiovascular System, Central Nervous System Infections, Ocular Infections, Soft Tissue Infections of the Head and Neck, Upper Respiratory Infections, Lower Respiratory Tract infections, Infections of the Gastrointestinal Tract, Intraabdominal Infections, Bone and Joint Infections, Urinary Tract Infections, Genital Infections, and Skin and Soft Tissue Infections; or into etiologic agent groups, including Tickborne Infections, Viral Syndromes, and Blood and Tissue Parasite Infections. Each section contains introductory concepts, a summary of key points, and detailed tables that list suspected agents; the most reliable tests to order; the samples (and volumes) to collect in order of preference; specimen transport devices, procedures, times, and temperatures; and detailed notes on specific issues regarding the test methods, such as when tests are likely to require a specialized laboratory or have prolonged turnaround times. There is redundancy among the tables and sections, as many agents and assay choices overlap. The document is intended to serve as a reference to guide physicians in choosing tests that will aid them to diagnose infectious diseases in their patients.

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“…1 In particular it was demonstrated that PVB19 is the causative agent of erythema infectiosum and may produce a transient aplastic crisis in predisposed patients and has been associated with hydrops fetalis, arthritis and chronic anaemia. 2,3 Moreover different viral infections, such as EpsteinBarr virus, Cytomegalovirus and Parvovirus B19 have been correlated with rheumatoid arthritis (RA).…”

Section: Introductionmentioning

confidence: 99%

Parvovirus B19 and immune disorders

Pugliese

Beltramo

Torre³

et al. 2006

Cell Biochemistry & Function

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Parvovirus B19 (PVB19) is the causative agent of erythema infectiosum and sometimes the infection is correlated with severe haematological complications, or in pregnancy to fetalis hydrops. Moreover some authors suggest an infection involvement in some autoimmune diseases. To this purpose we evaluated seroprevalence for PVB19 in following the autoimmune or dysreactive pathologies: systemic lupus erythematosus (SLE), cryoglobulinemia, idiopathic systemic--ANCA associated vasculitis, rheumatoid arthritis (RA). In the case of LES, 31/42 patients were positive for PVB19 versus 21/42 of blood donors, as controls subjects (73.8% vs. 50%; significant difference for p < 0.05), moreover a significant difference for p < 0.001 was detected comparing mean titre values of IgGs against PVB19 of two groups (UI 1.94 +/- 0.90 vs. 1.24 +/- 0.80). In contrast no significant differences were found in the case of percent seropositivity of cryoglobulinemic subjects (37/57 = 64.9%, the majority of whom were HCV+) in comparison with the control group (50%). However mean units index (UI) was 1.63 +/- 0.81; p = 0.019 versus the control group. Similar result, with regard to the percentage of seropositivity, was found for vasculitis (9/17 = 52.9%). The data reported here can confirm a possible correlation between PVB19 prior infection and LES and also suggest possible implications in the case of cryoglobulinemia. In fact, most of our patients were affected by a nephropathic or systemic form of HCV+ cryoglobulinemia and the presence of other infective cofactors could be suggestive in the evolution of this clinical situation.

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Diagnosis and Management of Human Parvovirus B19 Infection

Cited by 22 publications

References 20 publications

Parvovirus B19 Frequency in Exanthematic Cases Initialy Suspected as Measles or Rubella Infections in São Paulo, Brazil

Parvovirus B19 Frequency in Exanthematic Cases Initialy Suspected as Measles or Rubella Infections in São Paulo, Brazil

A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2013 Recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)a

Parvovirus B19 and immune disorders

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