Diagnosis and management of gastrointestinal complications in adult cancer patients: 2017 updated evidence-based guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Schmidt‐Hieber, Martin; Bierwirth, J.; Buchheidt, Dieter; Cornely, Oliver A.; Hentrich, Marcus; Maschmeyer, Georg; Schalk, Enrico; Vehreschild, Jörg Janne; Vehreschild, Maria J. G. T.

doi:10.1007/s00277-017-3183-7

Cited by 36 publications

(21 citation statements)

References 201 publications

(210 reference statements)

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“…In addition, Gram-negative bacteria are more commonly found as microorganisms causing blood stream infections (BSI) in neutropenic patients, compared with non-neutropenic patients [ 28 , 80 ]. This is likely due to bacterial translocation of gut organisms frequently causing BSI rather than CRI in neutropenic patients [ 81 ]. Increasing rates of antibiotic resistance including multi-drug resistance (MDR) have been reported worldwide in the last decade also in studies focusing on cancer patients [ 82 – 84 ].…”

Section: Resultsmentioning

confidence: 99%

Central venous catheter–related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

et al. 2020

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Cancer patients frequently require central venous catheters for therapy and parenteral nutrition and are at high risk of central venous catheter–related infections (CRIs). Moreover, CRIs prolong hospitalization, cause an excess in resource utilization and treatment cost, often delay anti-cancer treatment, and are associated with a significant increase in mortality in cancer patients. We therefore summoned a panel of experts by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) and updated our previous guideline on CRIs in cancer patients. After conducting systematic literature searches on PubMed, Medline, and Cochrane databases, video- and meeting-based consensus discussions were held. In the presented guideline, we summarize recommendations on definition, diagnosis, management, and prevention of CRIs in cancer patients including the grading of strength of recommendations and the respective levels of evidence. This guideline supports clinicians and researchers alike in the evidence-based decision-making in the management of CRIs in cancer patients.

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Section: Resultsmentioning

confidence: 99%

Central venous catheter–related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

et al. 2020

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“…Infectious diseases are the most frequent and life-threatening complications in cancer patients [20,21]. Antibiotics are frequently used in cancer patients both in hospital and in family for the treatment or prevention of infectious diseases [22,23].…”

Section: Discussionmentioning

confidence: 99%

Cephalosporin Antibiotics Specifically Enhance Conventional Chemotherapy in Nasopharyngeal Cancer

Ye²,

Song³

et al. 2020

Preprint

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Background: Cephalosporin antibiotics can drastically upregulate the expression of HMOX1 in nasopharyngeal carcinoma cells. HMOX1 has dual role in cancer cells, and is involved in chemoresistance. Cephalosporin antibiotics are widely used in the treatment of bacteria infectious diseases in cancer patients. Whether they affect the efficacy of chemotherapy is unknown. Methods: Comparisons between cefotaxime and the combination of cefotaxime and cisplatin were carried out throughout the study. Cell viability was detected by MTT method. Influence on clone formation of cancer cells was investigated by plate clone formation assay. The in vivo anticancer effect was determined via cancer xenograft in mice. Flow cytometry analysis was used to detect the apoptosis. Microarray gene expression profiling was analyzed using Gene Ontology analysis, and the differential genes were validated by RT-qPCR. Results: Cefotaxime specifically, selectively and synergistically enhanced the anticancer efficacy of cisplatin in nasopharyngeal carcinoma both in vitro and in vivo without increasing the toxicity, but it inhibited the cytotoxic effects of cisplatin in other cancers. Combination of cefotaxime and cisplatin significantly regulated 5 genes in direction favoring the enhancement of anticancer efficacy; of which, THBS1 and LAPTM5 were upregulated; PPP3CB, STAG1 and NCOA5 were downregulated jointly. HMOX1 contributes to the anticancer efficacy in combination group. Upregulated genes significantly modulated 18 apoptotic pathways, downregulated genes mainly affected assembly of genetic materials. Conclusion: Cephalosporin antibiotics are excellent and safe sensitizers of conventional chemotherapy in the treatment of nasopharyngeal carcinoma, but should be carefully used in other cancers.

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“…When any of these protective mechanisms are disrupted, infection can ensue. The gastrointestinal tract is a common site of infection in cancer patients, with causes including Clostridium difficile- associated colitis, cytomegalovirus (CMV) colitis, neutropenic enterocolitis, appendicitis, and intestinal perforation with secondary peritonitis and possibly abscess formation [ 34 ]. Clinical manifestations include abdominal pain, fever, diarrhea, and less commonly intestinal hemorrhage.…”

Section: Role Of Imaging In the Cancer Patient Infectionsmentioning

confidence: 99%

Imaging of abdominal and pelvic infections in the cancer patient

et al. 2021

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Diagnosis and management of gastrointestinal complications in adult cancer patients: 2017 updated evidence-based guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Cited by 36 publications

References 201 publications

Central venous catheter–related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Central venous catheter–related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Cephalosporin Antibiotics Specifically Enhance Conventional Chemotherapy in Nasopharyngeal Cancer

Imaging of abdominal and pelvic infections in the cancer patient

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