Diagnosis and Management of Gastroesophageal Reflux Disease in Children: Recommendations of Pediatric Gastroenterology Chapter of Indian Academy of Pediatrics, Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN)

Mohan, Neelam; Matthai, John; Bolia, Rishi; Agarwal, Jaya; Shrivastava, Rimjhim; Borkar, Vibhor

doi:10.1007/s13312-021-2400-6

Cited by 9 publications

(11 citation statements)

References 34 publications

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“…The recommendation is in line with ISPGHAN and NASPGHAN/ESPGHAN guidelines, which also recommend the use of ranitidine for short-term acid suppression in GERD. 5,11 Drug-induced gastritis is considerably prevalent in pediatrics. NSAIDs are the well-identified cause of gastritis in children.…”

Section: Discussionmentioning

confidence: 99%

“…4,39 In contrast to ranitidine, PPIs must be administered 30 to 60 minutes before meals for optimal efficacy, and it has a slow onset of action, making them less efficacious for on-demand use. 11 Nearly one-fourth of critically ill infants and children show complications associated with stress-induced mucosal damage and upper gastrointestinal bleeding. Prophylactic use of ranitidine is suggested in such indications in children.…”

Section: Discussionmentioning

confidence: 99%

“…Rapid onset of action is one of the benefits of H2RAs, which makes them useful for immediate relief of symptoms. 2,11 A randomized, single-dose, double-blind, placebo-controlled study evaluating oral ranitidine 75 mg in 29 children (4-11 years of age) with symptoms of GERD showed that intragastric pH begins to rise approximately 30 min after dosing with ranitidine. 4 On the contrary, PPIs generally require three days to achieve maximum impact; since it does not inhibit all the proton pumps immediately and is slow to achieve steadystate concentration.…”

Section: Evidence Summarymentioning

confidence: 99%

“…Also, PPIs have a slow onset of action, making them less efficacious for on-demand use. 11 Experts agreed that ranitidine is preferred for on-demand use in pediatric patients, and it should be considered when an immediate effect is expected in pediatric patients with gastritis.…”

Section: Evidence Summarymentioning

confidence: 99%

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Ranitidine use in pediatrics: current evidence-based review and recommendations

Pai

Kesavelu

Shah³

et al. 2022

Int J Contemp Pediatr

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Ranitidine plays a pivotal role in routine pediatric practice. The multi-dimensional use and safety of ranitidine are not supported by any practical guidelines, which led to recommendations convened by a group of experts based on evidence and the clinical experience of experts. A group of general pediatricians and pediatric gastroenterologists from India were part of this panel. This group of experts reviewed the literature on topics that were unanimously agreed upon, for which no recommendations were available. The Delphi method was implemented to reach unified decisions, which led to the development of evidence-based recommendations. Gastritis and gastroesophageal reflux disease (GERD) are common conditions seen in pediatric practice. Ranitidine has a rapid onset of action compared to proton pump inhibitors (PPIs). It is a preferred drug for on-demand use for gastritis and managing stress-induced gastric lesions in critically ill pediatric patients. Ranitidine has an established role in the management of GERD, and it also prevents nocturnal acid reflux effectively. It helps in reducing gastric fluid volume when used as preoperative prophylaxis. Also, ranitidine has a better safety profile in comparison to PPIs. Recommendations on the use and safety of ranitidine in pediatrics were developed which will be a guiding tool for all practicing clinicians, highlighting the strength and benefits of ranitidine as a better and safe alternative to PPIs in short-term acid suppression for multiple indications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Evidence Summarymentioning

confidence: 99%

Section: Evidence Summarymentioning

confidence: 99%

See 2 more Smart Citations

Ranitidine use in pediatrics: current evidence-based review and recommendations

Pai

Kesavelu

Shah³

et al. 2022

Int J Contemp Pediatr

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“…También hay evidencia de la existencia de ligandos naturales en el cerebro de personas que modulan el complejo receptor GABA/Benzodiazepina actuando como agonista, lo cual hace plantear la posibilidad de que los estados de ansiedad y el insomnio puedan ser consecuencia del déficit en la disponibilidad de dichos ligandos. El sistema serotoninérgico armoniza la conducta humana, así el descenso en la transmisión serotoninérgica facilita o desinhibe algunas actividades, planteándose por lo tanto que la ansiedad esté relacionada a la serotonina (6). Los estudios realizados han expuesto, que como ocurre con otras manifestaciones complejas del sistema nervioso central, no existe una región única encargada de la integración de la ansiedad.…”

Section: Fisiopatologíaunclassified

Pediatría General Tomo 2

Acuña¹,

Tapia²,

Gutiérrez³

et al. 2023

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Es un libro que se enfoca en proporcionar información detallada y actualizada sobre el cuidado de la salud infantil. El libro es especialmente útil para pediatras, residentes en pediatría y otros profesionales de la salud que trabajan con niños y buscan actualizar sus conocimientos en esta área. Incluye capítulos sobre una variedad de temas, como el desarrollo infantil, las enfermedades infantiles comunes, el manejo de emergencias pediátricas, entre otros. El libro está escrito por expertos en el campo y está ilustrado con imágenes y gráficos para una mejor comprensión. En resumen, es un libro de referencia valioso para los profesionales de la salud interesados en el cuidado de la salud infantil.

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