Diagnosis and Management of Dermatitis, Including Atopic, Contact, and Hand Eczemas

Chan, Cynthia X; Zug, Kathryn A.

doi:10.1016/j.mcna.2021.04.003

Cited by 20 publications

(12 citation statements)

References 60 publications

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“…While contact dermatitis is defined by itching and inflammation of the skin as a result of contact with external substances, atopic dermatitis is an inflammatory condition brought on by hereditary influences on immune cells and proteins that make up the skin. An inflammatory skin condition known as seborrheic dermatitis affects regions with a lot of sebaceous gland 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte

Kim,

Jeong,

Park

et al. 2023

Sci Rep

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The phenolic compounds in Lonicera japonica & Chenpi distillation extract (LCDE) were thoroughly examined for their antioxidant and anti-inflammatory properties. Phenolic compounds in LCDE were analyzed for five peaks using high-performance liquid chromatography (HPLC) combined with mass spectrometry (MS) and determined. Five phenolic compounds were identified from the samples and MS data. Ultrafiltration with LC analysis was used to investigate the ability of bioactive compounds to target DPPH. As a result, it was confirmed that the major compounds exhibited a high binding affinity to DPPH and could be regarded as antioxidant-active compounds. In addition, the anti-inflammatory effect of LCDE was confirmed in vitro, and signal inhibition of anti-inflammation cytokines, MAPK and NF-kB pathways was confirmed. Finally, Molecular docking analysis supplements the anti-inflammatory effect through the binding affinity of selected compounds and inflammatory factors. In conclusion, the phenolic compounds of the LCDE were identified and potential active compounds for antioxidant and anti-inflammatory activities were identified. Additionally, this study will be utilized to provide basic information for the application of LCDE in the pharmaceutical and pharmaceutical cosmetics industries along with information on efficient screening techniques for other medicinal plants.

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Section: Introductionmentioning

confidence: 99%

Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte

Kim,

Jeong,

Park

et al. 2023

Sci Rep

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“…Eczematous dermatitis may present on plantar feet and interdigital spaces such as toe webs [ 16 , 18 ]. While eczematous dermatitis is typically diagnosed clinically, a skin biopsy may be performed in equivocal cases, and patch testing may be used to rule out allergic contact dermatitis [ 31 ]. In a study of etiological causes of toe web intertrigo among 100 patients, Hassab-El-Naby et al identified biopsy-proven interdigital eczema in 52% of patients.…”

Section: Resultsmentioning

confidence: 99%

Gram-Negative Toe Web Infections

Waterton,

Lipner

2024

Dermatol Pract Concept

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Gram-negative bacterial toe web infection (GNTWI) is a common dermatologic condition affecting the interdigital spaces. The clinical presentation ranges from mild erythema to exudative maceration of the web spaces that may extend to in other areas of the foot and lead to cellulitis in severe cases. Pseudomonas aeruginosa is the most commonly identified etiologic agent. Occlusive and humid environments, pre-existing dermatologic conditions, and fungal infections increase the risk of developing GNTWI. GNTWI has a broad differential diagnosis including erythrasma, tinea pedis, pitted keratolysis, eczematous dermatitis, and malignancies. Diagnosis is performed using bacterial and fungal cultures. There is a lack of a standardized treatment regimen for GNTWI. While GNTWI is fairly common, it may still be under-recognized by dermatologists due to the limited medical literature. This article presents a review of GNTWI, its clinical features, epidemiologic factors, etiologic agents, predisposing factors, diagnostic methods, and therapeutic options.

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“…Lichen planus and its variants can have overlapping clinical presentations with diseases such as psoriasis, contact dermatitis, and lichenoid drug reactions. Clinical and histopathological findings may be insufficient to differentiate between lichenoid diseases and lichenoid reactions (caused by tact dermatitis is usually made by exclusion [35].…”

Section: Discussionmentioning

confidence: 99%

Dermatopathological Correlation of Clinically Challenging Cutaneous Lesions: A Single Center Experience of 2184 cases

Özcan¹,

Özlü²,

Karagün³

et al. 2022

Dermatol Pract Concept

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Introduction: Although textbooks provide the ideal clinical and histopathological findings, in practice we usually have fewer, and sometimes contradictory, findings to work with. Objectives: The primary goal of this study is to categorize the diagnoses of clinically challenging skin lesions, thereby identifying the most common diagnostic scenarios encountered by dermatopathologists in practice and the most perplexing differential diagnoses submitted by clinicians. Our secondary aim is to investigate how the case profile and clinician decision-making processes changed during the COVID-19 pandemic.Methods: We classified 2184 pathology reports into four major categories: inflammatory, neoplastic, non-diagnostic, and other. In each category, the three most frequently reported diagnoses were listed. For each listed diagnosis, the top 3 most frequently used differential diagnoses by the clinician prior to biopsy are listed. The period one year after and before the first nationally reported COVID-19 case was compared using the same classification.Results: The most common diagnoses and clinical differential diagnoses were listed for each category, with 45.4% being inflammatory and 27.4% being neoplastic diseases. Non-diagnostic reports accounted for 11.4% of all reports. The overall number of reports has decreased drastically since the pandemic, and the rates of keratinocytic and melanocytic neoplasms have increased, while the rates of other malignancies and spongiotic diseases have decreased.Conclusion: Although a trained eye can easily identify skin lesions when they are typical, even diseases we are familiar with can present atypically in real life. In these cases, histopathological examinations and clinicopathological correlation are critical in making an accurate diagnosis.

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Diagnosis and Management of Dermatitis, Including Atopic, Contact, and Hand Eczemas

Cited by 20 publications

References 60 publications

Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte

Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte

Gram-Negative Toe Web Infections

Dermatopathological Correlation of Clinically Challenging Cutaneous Lesions: A Single Center Experience of 2184 cases

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