Diagnosis and Management of Children With Mycobacterium abscessus Infections in the Head and Neck

Moe, Justine; Rajan, Roy; Caltharp, Shelley A.; Abramowicz, Shelly

doi:10.1016/j.joms.2018.03.016

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…Less frequent are specific cervical inflammations as a consequence of lymph node colliquation caused by the relatively frequent, in children (20%), extrapulmonary manifestation of tuberculosis, non-tuberculous mycobacteria, or actinomycetes [ 49 , 50 , 51 , 52 ] (a serious incident is the occurrence of a local epidemic of nosocomial Mycobacterium abscessus infection in children after dental treatment. The cause was contaminated dental unite cooling water [ 53 , 54 ]).…”

Section: Basic Microbial Findingsmentioning

confidence: 99%

Paediatric Deep Neck Infection—The Risk of Needing Intensive Care

et al. 2022

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Deep neck infections are potentially dangerous complications of upper respiratory tract or odontogenic infections. The pathophysiology, clinical presentation, and potential spreading depend on the complex anatomy of the neck fascia. These infections can lead to severe pathological conditions, such as mediastinitis, sepsis, and especially airway impairment with difficult management. Because of the risk of life-threatening emergency situations and the possible impacts on the overall health status of affected children, their early recognition is of utmost importance. Torticollis, drooling, and stridor are the most common signs of advancing disease. Children presenting with these symptoms should be admitted to the paediatric intensive care unit for vital function monitoring, where the airway could be readily secured if function is compromised.

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Section: Basic Microbial Findingsmentioning

confidence: 99%

Paediatric Deep Neck Infection—The Risk of Needing Intensive Care

et al. 2022

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“…Water extruded from these contaminated DUWS, either as a splatter or aerosol can pose a risk to both the patient as the dental staff [ 7 , 8 ]. Even though infections associated with contaminated DUWS water are likely to be underreported [ 9 ], some cases have been described for nontuberculous mycobacteria, which are associated with post-treatment oral soft tissue infections in both children and the elderly [ [10] , [11] , [12] , [13] ]. Additionally, Pseudomonas and Legionella species have been associated with occupational asthma, Pontiac Fever and even Legionnaire's Disease of dental staff and patients [ [14] , [15] , [16] ].…”

Section: Introductionmentioning

confidence: 99%

The consistent application of hydrogen peroxide controls biofilm growth and removes Vermamoeba vermiformis from multi-kingdom in-vitro dental unit water biofilms

Hoogenkamp

Mazurel

Deutekom-Mulder

et al. 2023

Biofilm

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“…It is imperative to exclude other possible organisms, such as TB, to guarantee proper management 6 . Nonetheless, diagnostic approaches such as the Tuberculin Skin Test (TST), Fine Needle Aspiration, or excisional biopsy have limitations in terms of sensitivity and specificity as well as the inadvertent complications of invasive testing 5 , 6 , 18 , 21 , 22 . The role of Purified Protein Derivative (PPD) has been evaluated with variable reported sensitivity of 5–50% for NTM and only improved role if cut off values are lowered which creates confusion in patients where prior TB exposure happened 4 , 6 , 10 , 13 , 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

“…NTM lymphadenitis has also been associated with hypoechogenicity and intranodal liquefaction on ultrasound 19 . These imaging findings are not considered specific; therefore, diagnostic models rely on the clinical and invasive test results 5 , 16 – 19 , 21 – 25 . More reliable and reproducible noninvasive image-based biomarkers that can increase accuracy for the diagnosis of NTM lymphadenitis would therefore be of great interest.…”

Section: Introductionmentioning

confidence: 99%

Radiomics and machine learning for the diagnosis of pediatric cervical non-tuberculous mycobacterial lymphadenitis

Bulushi

Saint‐Martin

Muthukrishnan

et al. 2022

Sci Rep

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Non-tuberculous mycobacterial (NTM) infection is an emerging infectious entity that often presents as lymphadenitis in the pediatric age group. Current practice involves invasive testing and excisional biopsy to diagnose NTM lymphadenitis. In this study, we performed a retrospective analysis of 249 lymph nodes selected from 143 CT scans of pediatric patients presenting with lymphadenopathy at the Montreal Children’s Hospital between 2005 and 2018. A Random Forest classifier was trained on the ten most discriminative features from a set of 1231 radiomic features. The model classifying nodes as pyogenic, NTM, reactive, or proliferative lymphadenopathy achieved an accuracy of 72%, a precision of 68%, and a recall of 70%. Between NTM and all other causes of lymphadenopathy, the model achieved an area under the curve (AUC) of 89%. Between NTM and pyogenic lymphadenitis, the model achieved an AUC of 90%. Between NTM and the reactive and proliferative lymphadenopathy groups, the model achieved an AUC of 93%. These results indicate that radiomics can achieve a high accuracy for classification of NTM lymphadenitis. Such a non-invasive highly accurate diagnostic approach has the potential to reduce the need for invasive procedures in the pediatric population.

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Diagnosis and Management of Children With Mycobacterium abscessus Infections in the Head and Neck

Cited by 6 publications

References 39 publications

Paediatric Deep Neck Infection—The Risk of Needing Intensive Care

Paediatric Deep Neck Infection—The Risk of Needing Intensive Care

The consistent application of hydrogen peroxide controls biofilm growth and removes Vermamoeba vermiformis from multi-kingdom in-vitro dental unit water biofilms

Radiomics and machine learning for the diagnosis of pediatric cervical non-tuberculous mycobacterial lymphadenitis

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