Diagnosis and management of cervical cancer

Petignat, Patrick; Roy, Michel

doi:10.1136/bmj.39337.615197.80

Cited by 167 publications

(135 citation statements)

References 25 publications

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“…The self-collected testing may be the alternative approach to clinician-collected specimens because it is less costly, less-invasive, and relatively practical in low-resource setting and in remote population (Petignat et al, 2007). In addition, self-collected is overwhelmingly preferred over Pap smear test because it can be done in relative privacy and less invasively.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Detection Sensitivity for Human Papillomavirus between Self-collected Vaginal Swabs and Physician-collected Cervical Swabs by Electrochemical DNA Chip

Nilyanimit¹,

Wanlapakorn²,

Niruthisard³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Human papillomavirus (HPV) DNA testing is an effective method to screen for precancerous changes in the cervix. Samples from self-collection rather than Pap smear can potentially be used to test for HPV as they are more acceptable and preferred for use in certain settings. The objective of this study was to compare HPV DNA testing from self-collected vaginal swabs and physician-collected cervical swabs. Materials and Methods: A total of 101 self-collected vaginal and physician-collected cervical swabs of known cytology from Thai women were tested by electrochemical DNA chip assay. The specimens were divided into 4 groups: 29 with normal cytology, 14 with atypical squamous cells of undetermined significance (ASCUS), 48 with lowgrade squamous intraepithelial lesion (LSIL), and 10 with high-grade squamous intraepithelial lesion (HSIL). Results: Positive detection rates of HPV from self-collected swabs were similar to those from physician-collected swabs. Among specimens with abnormal cytology, HPV was found in 50% of self-collected swabs and 47.2% of physician-collected swabs. In specimens with normal cytology, 17.2% of self-collected swabs and 24.1% of physician-collected swabs were positive for HPV. Concordance was relatively high between results from selfcollected and physician-collected samples. The most common HPV genotype detected was HPV 51. Conclusions: HPV DNA testing using self-collected swabs is a feasible alternative to encourage and increase screening for cervical cancer in a population who might otherwise avoid this important preventive examination due to embarrassment, discomfort, and anxiety.

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Section: Discussionmentioning

confidence: 99%

Comparison of Detection Sensitivity for Human Papillomavirus between Self-collected Vaginal Swabs and Physician-collected Cervical Swabs by Electrochemical DNA Chip

Nilyanimit¹,

Wanlapakorn²,

Niruthisard³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Typically, early cervical cancer is asymptomatic, but abnormal vaginal bleeding can occur, once the cancer becomes invasive (Petignat and Roy, 2007). Cervical cancer is the second most common cancer among women and the third leading cause of cancer deaths among women globally in low-resource settings (Zhao et al, 2012), affecting women at a time of life when they are critical to social and economic stability (Goldie et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Understanding and Responsiveness Level about Cervical Cancer and its Avoidance among Young Women of Pakistan

Khan¹,

Naeem²,

Khan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is one of the leading causes of morbidity and mortality amongst the gynecological cancers worldwide, especially in developing countries. There are few to no initial symptoms and signs. This study was conducted to assess the awareness level of young Pakistani women about cervical cancer and to educate them about this deadly disease. A detailed questionnaire regarding demographic data and information about cervical cancer was distributed in different cities of Punjab. A total of 873 women took part in this survey and 70.1 percent were totally unaware of this cancer. Only 8.5% of the whole surveyed population knew accurately about cancer of cervix, 7% of the surveyed respondents correctly specified the human papilloma virus as the causative agent. Only 5.2% respondents were able to identify the Pap smear test as a diagnostic measure. Out of all the surveyed population only 4.3% of individuals were found to be vaccinated against this disease and the majority was found from the medical profession. Medical professionals, students, working women, housewives and uneducated individuals took active part in this survey. This study demonstrates a low level of awareness among Pakistani women and a need for an active campaign by media and government to increase understanding as well as introducing measures for improved prevention and treatment of cervical cancer.

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“…This system, known as the Bethesda system, was developed in 1988 following a workshop sponsored by the National Cancer Institute which addressed the standardisation of cervical cytopathology reports (3). Premalignant cervical squamous abnormalities were divided into low grade squamous intraepithelial lesions (LSIL), which include features of HPV infection and CIN I (confined to the basal 1/3 of the epithelium), and high grade squamous intraepithelial lesions (HSIL), which include CIN II (confined to the basal 2/3 of the epithelium) and CIN III (2/3 of the entire epithelium) that may involve the full thickness (carcinoma in situ) (4).…”

Section: Introductionmentioning

confidence: 99%

Uterine cervical carcinoma: Role of matrix metalloproteinases (Review)

Libra¹

2009

Int J Oncol

114

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Abstract.Epidemiological and experimental studies have provided evidence that human papillomavirus (HPV) infection is a main player in the development of uterine cervical neoplasms. Migration of cancer cells from the origin tissue to surrounding or distant organs is essential for tumor progression. Many studies of tumor invasion and metastases have focused on the degradation of the extracellular matrix where matrix metalloproteinases (MMPs) play a central role. Two of these enzymes, MMP-2 and MMP-9, have been correlated with the processes of tumor cell invasion and metastasis in human cancers, including uterine neoplasms. It has been shown that the up-regulation of MMPs is associated with progression of cervical uterine neoplasms. This review describes the current understanding of MMP-2 and MMP-9 expression and activity in pre-cancer and cancer lesions of cervical uterine, which may open new strategies for diagnostic and therapeutic interventions.

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Diagnosis and management of cervical cancer

Cited by 167 publications

References 25 publications

Comparison of Detection Sensitivity for Human Papillomavirus between Self-collected Vaginal Swabs and Physician-collected Cervical Swabs by Electrochemical DNA Chip

Comparison of Detection Sensitivity for Human Papillomavirus between Self-collected Vaginal Swabs and Physician-collected Cervical Swabs by Electrochemical DNA Chip

Understanding and Responsiveness Level about Cervical Cancer and its Avoidance among Young Women of Pakistan

Uterine cervical carcinoma: Role of matrix metalloproteinases (Review)

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