Diagnosis and Management of Cardiac Sarcoidosis

Dubrey, Simon W; Falk, Rodney H.

doi:10.1016/j.pcad.2009.11.010

Cited by 132 publications

(121 citation statements)

References 46 publications

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“…Early enhancement of sarcoid granulomas in T2-weighted gadolinium images suggests presence of inflammation and edema, whereas late enhancement indicates fibrotic changes and scarring. 4,7 The most common areas of distribution are usually midmyocardial, with preferential involvement of the basal segments of the septum and lateral walls. 23 In a cohort of 16 patients with proven CS by revised Japanese Criteria, Smedema et al found 12 (75%) with LGE.…”

Section: Clinical Manifestations and Electrocardiogram Findingsmentioning

confidence: 99%

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Cardiac Sarcoid: A Clinician's Review on How to Approach the Patient With Cardiac Sarcoid

Mantini

Williams

Stewart

et al. 2012

Clinical Cardiology

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Cardiac sarcoid is an infiltrative, granulomatous disease of the myocardium. It is more prevalent entity than once believed, especially subclinical disease. It affects heart mechanics causing ventricular failure, and disrupts the cardiac electrical system leading to third degree heart block, malignant ventricular arrhythmias, and sudden cardiac death. This makes early diagnosis and treatment of this devastating disease essential. Based on reviewed literature this paper proposes step‐wise diagnostic and therapeutic algorithms for patients with suspected cardiac sarcoidoisis who do or do not have prior history of systemic sarcoidosis. Clin. Cardiol. 2012 DOI: 10.1002/clc.21982The authors have no funding, financial relationships, or conflicts of interest to disclose.Special thanks to Dr. Maziar Zafari for his help with the editing process.

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Section: Clinical Manifestations and Electrocardiogram Findingsmentioning

confidence: 99%

“…A stepwise diagnostic algorithm that will assist cardiologists in early diagnosis of CS is needed. 7 …”

Section: Introductionmentioning

confidence: 99%

Cardiac Sarcoid: A Clinician's Review on How to Approach the Patient With Cardiac Sarcoid

Mantini

Williams

Stewart

et al. 2012

Clinical Cardiology

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“…[19][20][21][22][23][24] Sarcoidosis of the pericardium can present as a pericardial effusion with or without hemodynamic instability. 25,26 Myocardial ischemia and infarction due to coronary artery involvement have also been described but are rare, 27 and myocardial fibrosis due to CS itself typically occurs in a nonvascular distribution and in some cases is the only evidence of prior active CS.…”

Section: Introductionmentioning

confidence: 99%

Joint SNMMI–ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring

Chareonthaitawee

Beanlands

Chen

et al. 2017

Journal of Nuclear Cardiology

174

133

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“…Emergent neurosurgical intervention may also be needed for obstructive hydrocephalus, due to space-occupying granulomas and communicating hydrocephalus due to involvement of the arachnoid granulations [186,187]. Sarcoid also affects the heart in up to 25% of patients with sarcoidosis and may manifest as left ventricular dysfunction with congestive heart failure, as well as potentially life-threatening arrhythmias due to granulomatous involvement of the conduction system [188].…”

Section: Nonvasculitic Systemic Inflammatory Disorders That Affect Thmentioning

confidence: 99%

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

Geldern¹,

McPharlin

Becker

2012

Neurotherapeutics

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This chapter will review the spectrum of immunemediated diseases that affect the nervous system and may result in an admission to the neurological intensive care unit. Immunomodulatory strategies to treat acute exacerbations of neurological diseases caused by aberrant immune responses are discussed, but strategies for long-term immunosuppression are not presented. The recommendations for therapeutic intervention are based on a synthesis of the literature, and include recommendations by the Cochrane Collaborative, the American Academy of Neurology, and other key organizations. References from recent publications are provided for the disorders and therapies in which randomized clinical trials and large evidenced-based reviews do not exist. The chapter concludes with a brief review of the mechanisms of action, dosing, and side effects of commonly used immunosuppressive strategies in the neurocritical care unit.

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Diagnosis and Management of Cardiac Sarcoidosis

Cited by 132 publications

References 46 publications

Cardiac Sarcoid: A Clinician's Review on How to Approach the Patient With Cardiac Sarcoid

Cardiac Sarcoid: A Clinician's Review on How to Approach the Patient With Cardiac Sarcoid

Joint SNMMI–ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

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