Diagnosis and Management of Basal Cell Carcinoma

Tanese, Keiji

doi:10.1007/s11864-019-0610-0

Cited by 103 publications

(138 citation statements)

References 92 publications

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“…Basal cell carcinomas can be classified in: BCC with adnexal differentiation, basosquamous carcinoma, nodular (solid), micronodular, infiltrative, fibroepithelial, keratotic, and sBCC (Tanese, ). Generally, BCCs have a low metastatic potential, but tumor infiltration may lead to recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, nodular BCCs are considered difficult to treat with topical treatments such as imiquimod and 5‐FU and even pigmented BCCs do not show great improvements with topical therapies (imiquimod). Therefore, an adequate evaluation of BCC subtypes is mandatory to decide the best treatment option (Tanese, ). Regarding our experience, we detected the presence of multiple pigmented sBCC in our patients, in accordance with dermoscopic criteria established by Pan and Lallas.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Basal cell carcinomas (BCC) are the most common cutaneous neoplasms, representing 80% of the total nonmelanoma skin cancers (NMSCs) diagnosed every year (Rubin, Chen, & Ratner, ). BCC is associated with chronic sun exposure, history of sunburns, immunosuppression, and continuous arsenic exposure (Tanese, ). For these reasons, BCC is more frequent among Caucasians on sun‐exposed areas of head and neck (Hoban, Ramachandran, & Strange, ).…”

Section: Introductionmentioning

confidence: 99%

“…BCC is associated with chronic sun exposure, history of sunburns, immunosuppression, and continuous arsenic exposure (Tanese, 2019). For these reasons, BCC is more frequent among Caucasians on sun-exposed areas of head and neck (Hoban, Ramachandran, & Strange, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Basal cell carcinomas treated with 0.5% 5‐fluorouracil and 10% salicylic acid topical solution

Diluvio

Lanna

Lozzi

et al. 2019

Dermatologic Therapy

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Basal cell carcinomas (BCCs) are the most common nonmelanoma skin cancers. Dermoscopy is an indispensable tool to differentiate superficial BCC from other subtypes and between pigmented and not pigmented ones. Although surgery is considered the gold‐standard therapy, new current pharmacological options are available and focus on tumor eradication, increasing cosmetic results and functionality. 5‐fluorouracil (5‐FU) is a cytostatic drug associated with antimetabolite effects and already approved as monotherapy for superficial BCCs treatment. A recent formulation combining of 5‐FU 0.5% with salicylic acid 10% has been indicated for the management of slightly palpable and/or moderately thick hyperkeratotic actinic keratosis of the face, forehead, and balding scalp in immunocompetent adult patients. This formulation has never been used as treatment for superficial BCC. In this article, we reported superficial BCC clinical and dermoscopic outcomes in two patients treated with this new topical agent, to assess its role in treating these lesions and to point out dermoscopy's usefulness in supporting clinical diagnosis and excluding tumor persistence or recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Basal cell carcinomas treated with 0.5% 5‐fluorouracil and 10% salicylic acid topical solution

Diluvio

Lanna

Lozzi

et al. 2019

Dermatologic Therapy

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Ultrasound Assessment of Skin Tumors Local Recurrence

Catalano

Crişan²,

Díaz

et al. 2023

J of Ultrasound Medicine

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Skin cancer may recur at or around the surgical site despite wide excisions. Prompt clinical and sonographic detection of local recurrence is important since subjects with relapsing melanomas or nonmelanoma malignancies can be managed efficaciously, with a relevant impact on morbidity and survival. Ultrasound is being employed with increasing frequency in the assessment of skin tumors, but most of the published articles relate to initial pretherapeutic diagnosis and staging. This review aims to offer an illustrated guide to the sonographic evaluation of locally recurring skin cancer. We introduce the topic, then we provide some sonographic tips for patient follow‐up, then we describe the ultrasound findings in case of local recurrence, illustrating the main mimickers, and finally, we mention the role of ultrasound in guiding diagnostic and therapeutic percutaneous procedures.

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Comparison of optical coherence tomography and in vivo reflectance confocal microscopy with dermoscopy for the diagnosis and management of nonmelanoma skin cancer: A randomized controlled trial

Hobelsberger,

Steininger,

Laske

et al. 2023

JEADV Clinical Practice

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BackgroundOptical coherence tomography (OCT) and reflectance confocal microscopy (RCM) can yield improved diagnostic accuracy of nonmelanoma skin cancer (NMSC) in comparison with dermoscopy alone.ObjectivesThe aim of this study was to compare the diagnostic performance of OCT and RCM together and individually with that of dermoscopy.MethodsPatients with lesions suspicious for NMSC were randomized into two groups in a prospective, single‐centre study. In the intervention group (IG), every lesion was examined with dermoscopy, OCT and RCM, while in the control group (CG), every lesion was examined with dermoscopy alone.ResultsA total of 365 lesions of 250 patients (105 female, 145 male) were included in the study. A total of 208 basal cell carcinomas (BCCs), 65 squamous cell carcinomas (SCCs) and 31 SCCs in situ were examined histologically. The IG involved significantly fewer biopsies than the CG (14 vs. 27, p = 0.029) and required fewer additional inpatient stays due to positive biopsy results (2 vs. 12, p = 0.001). For the diagnosis of BCC, diagnostic accuracy was 81% with dermoscopy, 84% with OCT, 83% with RCM and 85% with the combination of OCT and RCM (OCT/RCM). The diagnostic accuracy of OCT for BCC subtypes was as follows: superficial, 89%; nodular, 79%; sclerodermiform, 82%; and nodular‐cystic BCC, 75%. For the diagnosis of SCC, diagnostic accuracy was 85% with dermoscopy, 87% with OCT, 89% with RCM and 87% with OCT/RCM. For the diagnosis of in situ SCC, diagnostic accuracy was 87% with dermoscopy, 89% with OCT, 89% with RCM and 91% with OCT/RCM.ConclusionsDiagnostic accuracy increased with OCT and RCM and was even higher when both methods were used together. OCT and RCM could facilitate optimization of lesion management by reducing the number of punch biopsies and reducing additional inpatient stays due to positive biopsy results.

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Diagnosis and Management of Basal Cell Carcinoma

Cited by 103 publications

References 92 publications

Basal cell carcinomas treated with 0.5% 5‐fluorouracil and 10% salicylic acid topical solution

Basal cell carcinomas treated with 0.5% 5‐fluorouracil and 10% salicylic acid topical solution

Ultrasound Assessment of Skin Tumors Local Recurrence

Comparison of optical coherence tomography and in vivo reflectance confocal microscopy with dermoscopy for the diagnosis and management of nonmelanoma skin cancer: A randomized controlled trial

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