Diagnosis and management of antiphospholipid syndrome

Heuser, Cara; Branch, Ware

doi:10.1002/9781119072980.ch31

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…Corticosteroids, hydroxycloroquine and some immunosuppressive agents are reported to reduce aPL titres [21] [22].…”

Section: Treatmentmentioning

confidence: 99%

Antiphospholipid Syndrome: Nephrologists’ Perspective

Abdou¹,

Shoeib²,

Zahran³

2020

OJIM

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Introduction: Antiphospholipid antibody syndrome is a complex autoimmune disease that can affect all systems of the body and characterized by presence of antiphospholipid antibodies that cause vascular thrombosis and pregnancy complications, kidney involvement is very common in patients with antiphospholipid syndrome and leads to many serious complications. Objectives: study the effect of antiphospholipid syndrome on kidneys. Data Sources: By searching and reviewing Medline databases (Pub Med and Medscape) and all renal involvement in antiphospholipid syndrome materials available till 2019. Study Selection: All studies were independently assessed for inclusion. They were included if they fulfilled the following criteria: 1) published in English language; 2) published in peer-reviewed journals; 3) discussed the involvement of kidney in antiphospholipid syndrome. Data Extraction: Data from each eligible study were independently abstracted using a data collection form to capture information related to our concerned study outcomes. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment includes if ethical approval is gained, eligibility criteria specified, adequate information and defined assessment measured. Data Synthesis: Structured review with the results tabulated was made for comparison. Conclusions: We can conclude that kidney affection in patients with antiphospholipid syndrome has a wide spectrum and variation.

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“…Corticosteroids, hydroxycloroquine and some immunosuppressive agents are reported to reduce aPL titres [21] [22].…”

Section: Treatmentmentioning

confidence: 99%

Antiphospholipid Syndrome: Nephrologists’ Perspective

Abdou¹,

Shoeib²,

Zahran³

2020

OJIM

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“…The precise mechanisms underlying the pathogenesis of APS remain unclear; however, a multifactorial process similar to other autoimmune diseases has been posited involving a complex interplay between genetic predisposition, antigenic stimuli, and the presence of specific autoantibodies. APS is thought to involve the activation of several cell types, such as endothelial cells, monocytes, platelets, and trophoblast cells, the activation of the coagulation and complement systems, and the inhibition of fibrinolytic processes by antiphospholipid antibodies (aPLs) via cell surface receptors, including toll-like receptors (TLRs) [5,8]. Toll-like receptors (TLRs) are members of the pattern recognition receptor (PRR) family and play crucial functions in the innate immune system.…”

Section: Introductionmentioning

confidence: 99%

Genetic variation in toll-like receptor 4 gene with primary antiphospholipid syndrome susceptibility: a cohort of Egyptian patients

Mahdy

Elkader

Kassim

et al. 2022

Egypt J Med Hum Genet

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Background As toll-like receptor 4 (TLR4) plays important roles in cellular immunity and TLR4 polymorphisms have been shown to be associated with susceptibility to a range of diseases, the present study aimed to investigate the association between TLR4 gene polymorphisms and the incidence of primary antiphospholipid syndrome (PAPS). Methods Two TLR4 single nucleotide polymorphisms (rs4986790 and rs4986791) were assessed in 110 subjects of Egyptian ethnicity, including 65 female patients with PAPS and 45 matched healthy controls, using polymerase chain reaction-restriction fragment length polymorphism. Results were verified using automated sequencing. Results The homozygous wild-type (AA, aspartic acid) rs4986790 variant and (CC, threonine) rs4986791 variant were the predominant genotypes in the control and PAPS groups. Conclusion The results of this preliminary study of TLR4 gene variants among patients with PAPS in an Egyptian population found no association between the rs4986790 and rs4986791 variants and susceptibility to PAPS.

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