Diagnosis and follow-up of genital chlamydial infection by direct methods and by detection of serum IgG, IgA and secretory IgA

Fresse, AS; Sueur, JM; Hamdad, Farida

doi:10.4103/0255-0857.71823

Cited by 8 publications

(1 citation statement)

References 20 publications

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“…IgA is present both in serum and secretions of mucosal surfaces [4,5]. Its specific detection is considered a high-quality serological marker for other infectious diseases and it only persists as long as antigenic stimulation exists [6,7]. Except for one recent report [8], IgA has not been systematically evaluated in syphilitic patients for more than 25 years, despite being a potentially good marker for active infections, whose sensitivity and specificity could equal or exceed that of existing tests.…”

Section: Introductionmentioning

confidence: 99%

Anti-Treponema pallidum IgA response as a potential diagnostic marker of syphilis

Rodríguez,

Noda,

Bosshard

et al. 2023

Clinical Microbiology and Infection

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Section: Introductionmentioning

confidence: 99%

Anti-Treponema pallidum IgA response as a potential diagnostic marker of syphilis

Rodríguez,

Noda,

Bosshard

et al. 2023

Clinical Microbiology and Infection

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Effects ofChlamydia trachomatisinfection on sperm chromatin condensation and DNA integrity

et al. 2017

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The present study was performed to investigate the relation of Chlamydia trachomatis infection to sperm chromatin/DNA integrity in a population of infertile men (male partner of infertile couples) from Iran. Blood, semen and first-void urine samples were obtained from 250 infertile men. Data were analysed with regard to the results of (i) serological analysis for specific antibodies to C. trachomatis in serum; (ii) the presence of C. trachomatis and DNA in first-void urine; and (iii) in the semen sample of the male partner, in addition to sperm analysis, four different tests (aniline blue, chromomycin A3, acridine orange and TUNEL) were used to detect sperm chromatin and DNA abnormalities. The main conclusions of the results were: (i) no evidence of C. trachomatis infection in semen samples was found; (ii) sperm DNA fragmentation and chromatin studies were not correlated with C. trachomatis diagnosis; (iii) the percentage of DNA fragmentation is positively correlated with the percentage of immotile sperm but negatively with semen volume, normal morphology; and (iv) in sperm chromatin evaluations, only the percentage of chromatin protamination was related to male age.

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Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia

Naglak

Morrison

2017

Infect Immun

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Determining the effector populations involved in humoral protection against genital chlamydia infection is crucial to development of an effective chlamydial vaccine. Antibody has been implicated in protection studies in multiple animal models, and we previously showed that the passive transfer of immune serum alone does not confer immunity in the mouse. Using the Chlamydia muridarum model of genital infection, we demonstrate a protective role for both Chlamydia-specific immunoglobulin G (IgG) and polymorphonuclear neutrophils and show the importance of an antibody/effector cell interaction in mediating humoral immunity. While neutrophils were found to contribute significantly to antibody-mediated protection in vivo, natural killer (NK) cells were dispensable for protective immunity. Furthermore, gamma interferon (IFN-γ)-stimulated primary peritoneal neutrophils (PPNs) killed chlamydiae in vitro in an antibody-dependent manner. The results from this study support the view that an IFN-γ-activated effector cell population cooperates with antibody to protect against genital chlamydia and establish neutrophils as a key effector cell in this response.

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Diagnosis and follow-up of genital chlamydial infection by direct methods and by detection of serum IgG, IgA and secretory IgA

Abstract: Combining the positive direct methods and/or positive sIgA antibody results from cervical or urethral specimens had an indication of current C. trachomatis infection.

Cited by 8 publications

References 20 publications

Anti-Treponema pallidum IgA response as a potential diagnostic marker of syphilis

Anti-Treponema pallidum IgA response as a potential diagnostic marker of syphilis

Effects ofChlamydia trachomatisinfection on sperm chromatin condensation and DNA integrity

Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia

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