Diagnosis and clinical evaluation of neurogenic bladder

Amarenco, G.; Ismaël, Samer Sheikh; Chesnel, C.; Charlanes, A.; Breton, F. Le

doi:10.23736/s1973-9087.17.04992-9

Cited by 42 publications

(29 citation statements)

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“…Neurological disease commonly manifests in bladder dysfunction [175]. Autonomic nervous system lesions (stroke, tumor, traumatic spinal cord injury, myelopathies due to cervico-arthrosis spina bifida), disseminated lesions (Parkinson's disease, brain trauma, multiple sclerosis, meningo-encephalitis,) and peripheral neuropathies (diabetes mellitius) have all been identified as mechanisms of bladder dysfunction [175] and act in part by disrupting coordination between the detrusor, urinary sphincter, and central nervous system [173,174]. While there are many examples of environmental chemicals causing neuropathies, the consequences on lower urinary tract function are rarely examined.…”

Section: Urethral Mechanisms Of Male Lutdmentioning

confidence: 99%

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research

Peterson

Vezina

2022

Toxics

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Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research. Therefore, we direct this review to toxicologists who are considering male LUTD as a new aspect of chemical toxicity studies. We focus on the LUTD disease process in men, as well as in the male mouse as a leading research model. To introduce the disease process, we describe the physiology of the male lower urinary tract and the cellular composition of lower urinary tract tissues. We discuss known and suspected mechanisms of male LUTD and examples of environmental chemicals acting through these mechanisms to contribute to LUTD. We also describe mouse models of LUTD and endpoints to diagnose, characterize, and quantify LUTD in men and mice.

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Section: Urethral Mechanisms Of Male Lutdmentioning

confidence: 99%

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research

Peterson

Vezina

2022

Toxics

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“…Neurogenic lower urinary tract dysfunction (NLUTD) refers to abnormal function of either the bladder, bladder neck, and/or its sphincters caused by lesions to the central or peripheral nervous system ( Jahromi, Mure & Gomez, 2014 ; Panicker, DeSèze & Fowler, 2013 ). It is often clinically manifested as poor urination, urinary retention, abnormal ejaculation and other symptoms such as lower urinary tract and sexual dysfunction ( Amarenco et al, 2017 ). NLUTD could cause a series of urinary complications, such as hydronephrosis, pyelonephritis and urinary tract infection (UTI) ( Lima et al, 2015 ; Manack et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Early warning model construction and validation for urinary tract infection in patients with neurogenic lower urinary tract dysfunction (NLUTD): a retrospective study

Zhou

Liang

Qin³

et al. 2022

PeerJ

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Background This study was performed to construct and validate an early risk warning model of urinary tract infection in patients with neurogenic lower urinary tract dysfunction (NLUTD). Methods Eligible patients with NLUTD admitted to Shenzhen Longcheng hospital from January 2017 to June 2021 were recruited for model construction, internal validation and external validation. The first time point of data collection was within half a month of patients first diagnosed with NLUTD. The second time point was at the 6-month follow-up. The early warning model was constructed by logistic regression. The model prediction effects were validated using the area under the Receiver Operating Characteristic curve, the Boostrap experiment and the calibration plot of the combined data. The model was externally validated using sensitivity, specificity and accuracy. Results Six predictors were identified in the model, namely patients ≥65 years old (OR = 2.478, 95%CI [1.215– 5.050]), female (OR = 2.552, 95%CI [1.286–5.065]), diabetes (OR = 2.364, 95%CI) [1.182–4.731]), combined with urinary calculi (OR = 2.948, 95%CI [1.387–6.265]), indwelling catheterization (OR = 1.988, 95%CI [1.003 –3.940]) and bladder behavior training intervention time ≥2 weeks (OR = 2.489, 95%CI [1.233–5.022]); and the early warning model formula was Y = 0.907 × age+ 0.937 × sex + 0.860 × diabetes +1.081 × combined with urinary calculi+ 0.687 × indwelling catheterization+ 0.912 × bladder behavior training intervention time-2.570. The results show that the area under the ROC curve is 0.832, which is close to that of 1,000 Bootstrap internal validation (0.828). The calibration plot shows that the early warning model has good discrimination ability and consistency. The external validation shows the sensitivity is 62.5%, the specificity is 100%, and the accuracy is 90%. Conclusion The early warning model for urinary tract infection in patients with NLUTD is suitable for clinical practice, which can provide targeted guidance for the evaluation of urinary tract infection in patients with NLUTD.

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“…1 An affected element of this related system may lead to lower urinary tract dysfunction (LUTD). 2 LUTD is seen in the course of many neurologic diseases. In general, focal lesions (spinal cord injury, stroke, tumor), disseminated lesions (Parkinson disease, multiple sclerosis), and peripheral neuropathies (diabetes mellitus) are possible etiologies behind neurogenic bladder (NB).…”

Section: Introductionmentioning

confidence: 99%

“…In general, focal lesions (spinal cord injury, stroke, tumor), disseminated lesions (Parkinson disease, multiple sclerosis), and peripheral neuropathies (diabetes mellitus) are possible etiologies behind neurogenic bladder (NB). 2 NB refers to the dysfunction of the urinary bladder secondary to diseases of the nervous system that result in problems with bladder filling, emptying, or both. 3 Quality of life (QoL) of individuals with NB may be significantly impaired, 4 resulting in substantial psychological and economic burden.…”

Section: Introductionmentioning

confidence: 99%

“…8 NB patients have already an increased risk of having recurrent UTIs. 2 By emptying the residual urine in the bladder, clean intermittent catheterization (CIC) can help in reducing the risk of UTIs, but this procedure remains also a source for bacteria introduction into the urinary tract, putting the patients at a higher risk of developing symptomatic recurrent urinary tract infections (UTIs). 9 When neurological disorders are added to the loop, UTIs can become recurrent and extremely bothersome in some patients.…”

Section: Introductionmentioning

confidence: 99%

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Bladder instillation for urinary tract infection prevention in neurogenic bladder patients practicing clean intermittent catheterization: A systematic review

et al. 2021

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Objective: To assess the efficacy and safety of different modalities of bladder instillation in patients with neurogenic bladder practicing intermittent catheterization. Methods: A systematic review of the literature were conducted using two databases: Medline via PubMed and Scopus. Articles evaluating bladder instillation in patients with neurogenic bladder, who are practicing intermittent catheterization, were collected and assessed for the efficacy and safety of the studied agent by two different reviewers. Results: Among the 1896 studies, eight involving 346 patients with neurogenic bladder, were included in this systematic review according to the PRISMA protocols. Gentamicin, Hyaluronic acid, and Lactobacillus rhamnosus was found to decrease the incidence of urinary tract infections, the former reduced multidrug-resistant organisms. Kanamycin-colistin, showed a drop in the mean incidence of bacteriuria in males only. Trisdine, the only studied antiseptic, significantly reduced bacteriuria. Neomycin, however, showed no efficacy in term of bacteriuria. Regarding safety, when evaluated, no major adverse events were reported with any of the studied modalities. Conclusion: Bladder instillations of either antibiotics, antiseptics, hyaluronic acid, or Lactobacillus rhamnosus GG are efficient and safe in patients having neurogenic bladder, with recurrent urinary tract infections and practicing clean intermittent catheterization, with gentamicin being the most recommended product among the different studied agents.

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Diagnosis and clinical evaluation of neurogenic bladder

Cited by 42 publications

References 0 publications

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research

Early warning model construction and validation for urinary tract infection in patients with neurogenic lower urinary tract dysfunction (NLUTD): a retrospective study

Bladder instillation for urinary tract infection prevention in neurogenic bladder patients practicing clean intermittent catheterization: A systematic review

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