Diagnosis and assessment of food allergy in children and young people: summary of NICE guidance

Sackeyfio, Alfred; Senthinathan, A.; Kandaswamy, P.; Barry, PW; Shaw, Briony; Baker, Mark

doi:10.1136/bmj.d747

Cited by 31 publications

(25 citation statements)

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“…Seventy-nine infants were enrolled (34 infants with FA and 45 healthy controls) ( Table 1). FA was diagnosed and assessed according to the National Institute for Health and Clinical Excellence (NICE) guidelines (1,15). Infants with suspected FA who were brought to the Department of Pediatrics of Peking University Third Hospital for evaluation between June 2012 and June 2013 had their FA established by means of clinical history or symptoms and confirmed with skin prick tests (SPTs) and oral food challenges with successive doses of milk, eggs, wheat, nut, peanuts, fish, shrimp, and soy beans.…”

Section: Methodsmentioning

confidence: 99%

“…ood allergy (FA) is a common allergic disorder characterized by adverse immune and hypersensitivity reactions to food proteins (1). The prevalence of FA has been increasing worldwide in recent decades, reaching 6% among children Ͻ3 years of age and approximately 4% of adults in the United States, resulting in a considerable public health and economic burden (2).…”

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confidence: 99%

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Altered Fecal Microbiota Composition Associated with Food Allergy in Infants

Ling

Liu

et al. 2014

Appl Environ Microbiol

303

260

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Increasing evidence suggests that perturbations in the intestinal microbiota composition of infants are implicated in the pathogenesis of food allergy (FA), while the actual structure and composition of the intestinal microbiota in human beings with FA remain unclear. Microbial diversity and composition were analyzed with parallel barcoded 454 pyrosequencing targeting the 16S rRNA gene hypervariable V1-V3 regions in the feces of 34 infants with FA (17 IgE mediated and 17 non-IgE mediated) and 45 healthy controls. Here, we showed that several key FA-associated bacterial phylotypes, but not the overall microbiota diversity, significantly changed in infancy fecal microbiota with FA and were associated with the development of FA. The proportion of abundant Bacteroidetes, Proteobacteria, and Actinobacteria phyla were significantly reduced, while the Firmicutes phylum was highly enriched in the FA group (P < 0.05). Abundant Clostridiaceae 1 organisms were prevalent in infants with FA at the family level (P ‫؍‬ 0.016). FA-enriched phylotypes negatively correlated with interleukin-10, for example, the genera Enterococcus and Staphylococcus. Despite profound interindividual variability, levels of 20 predominant genera were significantly different between the FA and healthy control groups (P < 0.05). Infants with IgE-mediated FA had increased levels of Clostridium sensu stricto and Anaerobacter and decreased levels of Bacteroides and Clostridium XVIII (P < 0.05). A positive correlation was observed between Clostridium sensu stricto and serum-specific IgE (R ‫؍‬ 0.655, P < 0.001). The specific microbiota signature could distinguish infants with IgE-mediated FA from non-IgE-mediated ones. Detailed microbiota analysis of a well-characterized cohort of infants with FA showed that dysbiosis of fecal microbiota with several FA-associated key phylotypes may play a pathogenic role in FA.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Altered Fecal Microbiota Composition Associated with Food Allergy in Infants

Ling

Liu

et al. 2014

Appl Environ Microbiol

303

260

View full text Add to dashboard Cite

show abstract

“…A clear cause and effect between food ingestion and symptoms might not be clear because the symptoms of these types of food allergy are typically chronic versus immediate but on toxic effects. Non that are immune whereas non immune [15]. Intradermal tests, total serum IgE measure, and atopy patch tests were not recommended for use in diagnosing food allergy in the NIAID-sponsored guidelines and in the Diagnosis and Rationale for Action against Cow's Milk Allergy guidelines sponsored by the World Allergy Organization mediated react.…”

Section: Mixed Ige-and Non-ige-mediated or Non-ige Mediated Food Allergymentioning

confidence: 99%

The Progress of Food Allergy Concept, Classifications and Diagnosis

Kamal-Alahmad¹

2016

IJNFS

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Food allergies, defined as an immune response to food proteins, affect as many as 8% of young children and 5% of adults in most countries, and their prevalence appears to be rising like all allergic diseases, In addition to well-recognized urticaria and anaphylaxis triggered by IgE antibody-mediated immune responses. Food allergy is a rapidly growing public health concern because of its increasing prevalence and life-threatening potential. Food allergic reaction can be further subdivided into IgE mediated and non IgE mediated. The diagnosis of food allergy is made from the history, supported by investigations and by responses to avoidance of specific food triggers. So in this work we want to introduce some concepts in food allergy such as classification of allergic and diagnosis of food triggers and finally how to manage this problem and minimize the prevalence of food allergy.

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“…Physical examination of the patient can identify signs of an allergic reaction, but also can detect signs of a nonallergic disorder that would require investigation. Usual laboratory tests can detect eosinophilia [17].…”

Section: Diagnostic Approachmentioning

confidence: 99%

Food Allergy: Always a Threat, How do We Treat it?

Floca¹

2013

Pharmaceut Anal Acta

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Diagnosis and assessment of food allergy in children and young people: summary of NICE guidance

Cited by 31 publications

References 1 publication

Altered Fecal Microbiota Composition Associated with Food Allergy in Infants

Altered Fecal Microbiota Composition Associated with Food Allergy in Infants

The Progress of Food Allergy Concept, Classifications and Diagnosis

Food Allergy: Always a Threat, How do We Treat it?

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