Diagnosing Lymphoproliferative Disorders Using Core Needle Biopsy Versus Surgical Excisional Biopsy: Three-Year Experience of a Reference Center in Lebanon

Assaf, Nada; Nassif, Samer; Tamim, Hani; Bazarbachi, Ali; Zaatari, Ghazi; Chakhachiro, Zaher

doi:10.1016/j.clml.2019.11.013

Cited by 12 publications

(16 citation statements)

References 31 publications

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“…In this study, the specimens obtained via this puncture method had an overall positive rate of 79.2% in histopathological diagnosis, with no significantly statistical difference compared to CNB. In fact, domestic and foreign scholars ( 17 – 19 ) have reported that the overall positive rate of CNB ranges from 79.0% to 95.9%, which is close to the overall positive rate of CNB obtained in the current study. Therefore, we believe that the overall diagnostic positive rate of the modified needle biopsy method is close to that of CNB, which implies that the former has high diagnostic properties.…”

Section: Discussionsupporting

confidence: 89%

The diagnostic value and safety of modified needle aspiration biopsy for superficial lymphadenectasis

Hua

Zhao

et al. 2022

Front. Surg.

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ObjectiveTo explore the safety and diagnostic value of modified needle aspiration biopsy for superficial enlarged lymph nodes.MethodsA total of 88 patients with unknown diagnosis of superficial lymphadenopathy in our hospital (Wuxi Fifth People's Hospital) from January 2018 to July 2021 were recruited and then divided into two groups using the simple random grouping method. The study group included 48 patients who were punctured via modified needle aspiration biopsy, while the control group included 40 patients who were punctured via core needle biopsy (CNB) and had a better clinical evaluation. A BARD® automatic biopsy gun with a 18 G needle was used to puncture any enlarged lymph nodes, and specimens were obtained for pathological examination. The diagnostic positive rate of the two puncture methods was then compared and the complications involved in the two methods were observed.ResultsThe positive rate of definite pathological diagnosis was 79.2% (38/48) in the study group and 82.5% (33/40) in the control group. Both groups had similar diagnostic positive rates regarding tuberculosis and metastatic tumours in the lymph nodes (P > 0.05). Only slight bleeding was observed during the operations using the two puncture methods, with the bleeding rate of the study group 20.8% and that of the control group 15.0%, and the difference was not statistically significant (P > 0.05). No other complications were observed across both groups. Among the 48 patients with enlarged lymph nodes in the study group, there was no difference in the positive rate of diagnosis between enlarged lymph nodes larger than 20 mm and those smaller than 20 mm in the pathological, bacterial culture and cytology examinations (P > 0.05). The sensitivity, specificity, positive predictive values and negative prediction values of the improved lymph node lesions were 83.3%, 100%, 100% and 90.9%, respectively.ConclusionThe diagnostic efficacy and safety of modified needle aspiration biopsy in superficial swollen lymph nodes are equivalent to those of CNB, but the former is a more economical, simple and practical method for clinical settings and one that could be popularised in primary hospitals.

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Section: Discussionsupporting

confidence: 89%

The diagnostic value and safety of modified needle aspiration biopsy for superficial lymphadenectasis

Hua

Zhao

et al. 2022

Front. Surg.

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“…We propose that image‐guided CNB should be considered the first‐line diagnostic intervention of choice in suitable patients and that SNB should be reserved for cases where diagnostic uncertainty exists. Specific guidelines need to be updated on how best to use CNB in conjunction with ancillary diagnostic tests, such that diagnostic accuracy continues to remain optimal 29 …”

Section: Resultsmentioning

confidence: 99%

Image‐guided core needle biopsy as the first‐line diagnostic approach in lymphoproliferative disorders—A review of the current literature

Seviar

Yousuff

Chia

et al. 2020

European J of Haematology

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The World Health Organization (WHO) and numerous expert guidelines for lymphoma diagnosis and subclassification advocate the use of histology from surgical nodal excision biopsy (SEB) over core needle biopsy (CNB) due to perceived higher diagnostic yield. CNB is associated with lower morbidity and is more cost‐effective compared to SEB. Furthermore, current practice increasingly demonstrates material obtained from CNB can rapidly diagnose individuals with a clinical suspicion of lymphoma and allow initiation of treatment in the majority of patients. We performed a literature review to assess the suitability of CNB in lymphoma diagnosis given recent advances in radiological and histopathological techniques in obtaining and processing tissue. Additionally, expert international guidelines in lymphoma diagnosis were compared. We found that CNB demonstrated a diagnostic efficacy between 79% and 97% (median 91%) where the diagnostic outcome was conclusive with full lymphoma subclassification. Studies demonstrate that there is a high diagnostic reproducibility amongst haematopathologists (87%‐93%) in lymphoma diagnoses with full subtyping from material obtained via CNB. Furthermore, CNB is a safe, rapid and reliable method of obtaining tissue from lymph nodes for histopathological analysis. These procedures are minimally invasive, well‐tolerated and should be considered the first‐line diagnostic approach in clinical practice in patients with suspected lymphoproliferative disorders.

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“…Among the 96 patients with nodal lesions diagnosed as lymphomatous on the reference standard, 90 were classified in the same way, that is, as HL, by reference standard as they were by CNB; consequently, the accuracy rate of lymph node status was 94% (95% CI 87–97%) for PDUS‐guided 16‐G CNB (Table II). 6,11,15 Noteworthy, in our hands, the rate of failure with core biopsy was very low. In fact, stiffened tissue of the nodal sclerosis HL, which was seated in the sub‐clavicular area (a particulary difficult region) led to a sampling error of CNB in only a minority of patients, that is, six patients with fibrotic samples, that necessarily required re‐biopsy (surgical resection) for correctly diagnosing the disease.…”

Section: Characteristic All Patients True‐positive Cnb False‐negativementioning

confidence: 56%

Correspondence in reference to the previously published Epub manuscript by Peter Hokland et al. ‘How I treat advanced Hodgkin lymphoma – a global view’. Br J Haematol. 2020;190:837–50

et al. 2021

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Diagnosing Lymphoproliferative Disorders Using Core Needle Biopsy Versus Surgical Excisional Biopsy: Three-Year Experience of a Reference Center in Lebanon

Cited by 12 publications

References 31 publications

The diagnostic value and safety of modified needle aspiration biopsy for superficial lymphadenectasis

The diagnostic value and safety of modified needle aspiration biopsy for superficial lymphadenectasis

Image‐guided core needle biopsy as the first‐line diagnostic approach in lymphoproliferative disorders—A review of the current literature

Correspondence in reference to the previously published Epub manuscript by Peter Hokland et al. ‘How I treat advanced Hodgkin lymphoma – a global view’. Br J Haematol. 2020;190:837–50

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