Diagnosing clinical subsets of autoimmune liver diseases based on a multivariable model

Abstract

A seven-variable formula based on three laboratory tests and four histological features gives significant information for the diagnosis of AILD.

Application and Validation of a New Histologic Staging and Grading System for Primary Biliary Cirrhosis

“…In this current study, we validated our new system using liver biopsy specimens of prototypic PBC and compared our analysis with our new classification system to the classical classification system. histological findings assessed by three hepatopathologists) in our previous study, 13 portal fibrosis, bile duct injury (including CNSDC and granulomatous cholangitis), bile duct loss, interface hepatitis, and lobular hepatitis were used for our classification system in this study.…”

Leberwerterhöhung bei rheumatoider Arthritis

“…In Assoziation zur Zöliakie treten aber auch die primär biliäre Zirrhose (PBC) und die primär sklerosierende Cholangitis (PSC) auf [18]. Negative antimitochondriale Antikörper und ANCA sowie der hö-here Anstieg von ALT und AST als der von Gamm-GT und AP sprachen (bei Annahme eines autoimmunen Geschehens) jedoch mehr für die AIH als für die letztgenannten Erkrankungen [30].…”

Is the new diagnostic scoring system of Zeniya and colleagues useful for autoimmune liver diseases?

“…In this issue of the Journal of Gastroenterology, Zeniya and colleagues 22 have reported seven variables that may be important for the diagnosis of autoimmune liver diseases. 22 They performed multiple logistic regression analyses to determine variables that could distinguish AIH and PBC from non-AIH and non-PBC, respectively, in a prototype group.…”

“…This can be seen in serial liver biopsy sections. Thirdly, in the system proposed by Zeniya et al, 22 there are many pathological findings compared to clinical markers, and diagnosis according to the pathological findings may not be easy for general physicians.…”

“…22 They performed multiple logistic regression analyses to determine variables that could distinguish AIH and PBC from non-AIH and non-PBC, respectively, in a prototype group. Seven variables-three laboratory tests (ALP, ALT, and AMA) and four histological findings (bile duct injury, bile duct loss, hepatocyte rosette formation, and lobular hepatitis)-were selected.…”