Diagnosing Celiac Disease

Baudon, Jean-Jacques; Johanet, Catherine; Absalon, Yvan Boniface; Morgant, Georges; Cabrol, Sylvie; Jf, Mougenot

doi:10.1001/archpedi.158.6.584

Cited by 38 publications

(8 citation statements)

References 35 publications

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“…Our study is in accordance with previous studies showing that AGA-IgA should no longer be performed because of a lack of specificity or a lack of sensitivity when compared with tTG-IgA and EMA-IgA (11,15,22,23). Another study gave the same results, showing that all of the AGA-IgA-positive results in the presence of negative tTG/EMA were false-positives (17).…”

Section: Discussionsupporting

confidence: 92%

Are Immunoglobulin A Anti‐gliadin Antibodies Helpful in Diagnosing Coeliac Disease in Children Younger Than 2 Years?

Foucher

Johanet²,

Jego-Desplat³

et al. 2012

J. pediatr. gastroenterol. nutr.

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The usefulness of immumoglobulin (Ig) A antibodies to gliadin (AGA-IgA) in addition to IgA anti-endomysium and tissue transglutaminase antibodies was evaluated in 4122 children younger than 2 years with a suspicion of coeliac disease (CD). Eight percent (312/4122) displayed IgA anti-endomysium and/or IgA anti-tissue transglutaminase, whereas 2.1% (85/4122) displayed only AGA-IgA. Clinical data were obtained for 62 of 85 children with isolated AGA-IgA, and 33 children underwent a duodenal biopsy. Histologically proven CD was established for 5 patients, whereas 57 children were diagnosed to experience other diseases. The systematic detection of AGA-IgA using native gliadin conferred no additional diagnostic benefit for the diagnosis of CD in children younger than 2 years of age, except for rare cases.

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Section: Discussionsupporting

confidence: 92%

Are Immunoglobulin A Anti‐gliadin Antibodies Helpful in Diagnosing Coeliac Disease in Children Younger Than 2 Years?

Foucher

Johanet²,

Jego-Desplat³

et al. 2012

J. pediatr. gastroenterol. nutr.

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“…The anti-tTG assay emerged as a great hope for celiac disease screening, since it is an easily-executed test with a relatively low cost and can be used in screening studies, with similar results to those obtained using AEA, which is considered the best serological test for this disease (14,(16)(17)(18) . The AEA takes longer, costs more and is operator-dependent, which can lead to errors (14,17,19,20) .…”

Section: Discussionmentioning

confidence: 93%

Soropositividade para doença celíaca em crianças e adolescentes com baixa estatura

Gueiros¹,

Silva²

2009

Rev. paul. pediatr.

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OBJETIVO: Avaliar a frequência da positividade do marcador sorológico para doença celíaca em crianças e adolescentes com baixa estatura, utilizando-se o anticorpo anti-transglutaminase humana como teste de triagem. MÉTODOS: Estudo descritivo com amostra obtida por conveniência. Foi realizado no período de abril a setembro de 2004 no Ambulatório Geral de Pediatria do Instituto Materno Infantil Professor Fernando Figueira e no Ambulatório de Crescimento e Desenvolvimento do Hospital das Clínicas. Foram considerados casos as crianças e os adolescentes portadores de baixa estatura, definida como aquela abaixo do percentil 3 para idade e sexo, utilizando como referência o gráfico de altura/idade do National Center for Health Statistics, 2000. Foi pesquisado o anticorpo anti-transglutaminase humana (AATGh), considerado positivo se concentração >20U/mL e, nos positivos, o anticorpo antiendomísio (AAE). RESULTADOS: Foram avaliados 78 pacientes, sendo 41 (53%) do sexo feminino. O AATGh foi positivo em 3/78 (3,8%) dos pacientes. O AAE foi positivo em um paciente, naquele com concentração mais elevada do AATGh. Considerando-se a positividade para os dois testes, a soropositividade foi de 1,3%. CONCLUSÕES: A presença de marcador sorológico para doença celíaca em crianças e adolescentes portadoras de baixa-estatura e pertencentes a famílias de baixa-renda aponta para a necessidade de investigação sistemática da doença celíaca nesses pacientes.

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“…Over recent years, attempts have been made to find other diagnostic methods with good sensitivity and specificity for the screening and diagnosis of celiac patients .The anti-tTG assay emerged as a great hope for celiac disease screening, since it is an easily-executed test with a relatively low cost and can be used in screening studies (7)(8)(9) . The AEA takes longer, costs more and is operator-dependent, which can lead to errors (8,(10)(11)(12) . Based on the available evidence and on practical considerations, anti-tTG is the primary test recommended for screening (8,11) .…”

Section: Discussionmentioning

confidence: 99%

Percentage of Patient with Celiac Disease among Children with Short Stature

Abed¹

2016

Kufa Jour. Nurs. Sci.

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Background: Clinical features of celiac disease vary considerably. Intestinal symptoms are common in children whose disease is diagnosed within the 1st 2 years of life. As the age at presentation of the disease shifts to later in childhood, and with the more liberal use of serologic screening tests, extra-intestinal manifestations and associated disorders, without any accompanying digestive symptoms, have increasingly become recognized, including short stature. We aim in this study to determine the percentage of celiac disease among patients with short stature. Objectives of the Study: (1) to show the percentage of patient with celiac disease in short stature children. (2) to show the effect celiac disease on treatment of short stature children. Methodology: A cross sectional study that carried out at the Endocrine Pediatrics Clinic at A Zahraa Teaching Hospital for a period in 1st of January 2013 to end of October 2013; a total of 167 children and adolescents, aged range of 2 to 18 years were registered with short stature . 91 children of them only have been enrolled in this study according to inclusion criteria. Enzyme immunoassay (Biosystems, Spain) was used to determine IgA tTG using microplate tests. Samples with concentrations >20U/mL were defined as positive. Patients with positive anti-tTGserology were referred to the gastroenterology clinic to continue investigation of celiac disease by endoscopy and biopsy. Data were analyzed by SPSS software in IBM version 20 using chi square and paired T-test. Result: A total of 167 patients were evaluated 91 of them only have been enrolled in our study according to inclusion criteria; 59 (65%) were female and 32 (35%) were male. Median age was 9 years (of 2 - 18 years).The anti-tTG assays were positive in 16.5% of patients (15/91). Out of 15 patient whose diagnosed as anti-tTG positive, 11 (73%) have been diagnosed as celiac disease by endoscopy and biopsy according to modified marsh classification. All children diagnosed to have celiac disease were kept on a gluten-free diet. Patients were followed-up for six months and showed improvement in growth rate. Conclusion: Celiac disease a cause of short stature that should be included in diagnostic investigations of short stature.Recommendation: anti-tTG antibody as routine test recommended for all patients with short statures. All patients with idiopathic short statures and anti-tTG test positive with normal IgA level should be subjected to intestinal biopsy to prove the diagnosis of celiac disease.

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Diagnosing Celiac Disease

Abstract: The presence of human anti-tTG is a reliable indicator for the diagnosis and follow-up of CD.

Cited by 38 publications

References 35 publications

Are Immunoglobulin A Anti‐gliadin Antibodies Helpful in Diagnosing Coeliac Disease in Children Younger Than 2 Years?

Are Immunoglobulin A Anti‐gliadin Antibodies Helpful in Diagnosing Coeliac Disease in Children Younger Than 2 Years?

Soropositividade para doença celíaca em crianças e adolescentes com baixa estatura

Percentage of Patient with Celiac Disease among Children with Short Stature

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