Diagnosing and Treating Inflammatory Myofibroblastic Tumor of the Bladder

Abstract

Inflammatory myofibroblastic tumor (IMT) is an uncommon condition that is rarely encountered in the urinary tract. In this report, we present a case of IMT of the bladder in a woman with multiple previous pelvic surgeries. We further review the relevant literature to highlight this rare but important clinical presentation.

Inflammatory myofibroblastic tumour of the bladder: a case report and review of the literature

“… 2 Although partial or even radical cystectomy can ensure complete tumour excision, the course of the disease is generally benign, and a less invasive endoscopic resection (TURBT) may be preferable, particularly in patients hesitant to undergo radical surgery or for patients who are poor candidates for major surgery. 2 , 7 Recurrence is seen in as many as 10–25% of cases, but such recurrences have been observed to have a relatively benign course. 7 Tumours that have been incompletely excised have been seen to regress or remain stable.…”

“… 2 , 7 Recurrence is seen in as many as 10–25% of cases, but such recurrences have been observed to have a relatively benign course. 7 Tumours that have been incompletely excised have been seen to regress or remain stable. 8 There is a lack of evidence to support chemotherapy or radiotherapy in the treatment of these tumours.…”

Robot-assisted Partial Cystectomy for Treatment of Inflammatory Myofibroblastic Tumor of the Bladder

“…IMTs are generally benign in nature without reported cases of metastasis. Even incomplete resection of IMTs has proven beneficial as remaining IMT cells are noted to remain stable or regress spontaneously 3, 4…”

“…The mainstay of treatment for IMTs of the urinary bladder is local surgical resection, including partial cystectomy and transurethral resection of the bladder tumor (TURBT) 4 . Recurrence after resection occurs in 10%–25% of patients but usually follows an indolent course 4 . Here we present a case of inflammatory myofibroblastic tumor of the bladder in an otherwise healthy young man.…”

“…Translocation in the anaplastic lymphoma kinase (ALK) gene on band 2p23 is present in 30%–66% of IMTs and immunohistochemical staining can allow for differentiation of IMTs from other spindle cell lesions of the bladder 3 . The mainstay of treatment for IMTs of the urinary bladder is local surgical resection, including partial cystectomy and transurethral resection of the bladder tumor (TURBT) 4 . Recurrence after resection occurs in 10%–25% of patients but usually follows an indolent course 4 .…”