Diagnosing and Treating Food Allergy

Canani, Roberto Berni; Nocerino, Rita; Pezzella, Vincenza; Leone, Ludovica; Cozzolino, Tommaso; Aitoro, Rosita; Paparo, Lorella; Costanzo, Margherita Di; Cosenza, Linda; Troncone, Riccardo

doi:10.1007/s40124-013-0027-3

Cited by 5 publications

(2 citation statements)

References 59 publications

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“…The concomitant presence of a positive family history for atopic disorders, vomiting, stool pattern modifications or extra-intestinal symptoms of atopy (eczema and/or wheezing) strongly suggests the presence of FA in a subject with IC. In this case, a prompt evaluation of the infant, including in-depth patient history, physical examination, response to elimination diet and to oral food challenge (OFC), is important to confirm a final diagnosis of FAs [ 49 ]. FA screening tests (skin prick test, atopy patch test, serum-specific IgE) could be useful, but they are not mandatory for diagnosis [ 50 , 51 ].…”

Section: Evidencementioning

confidence: 99%

The Controversial Role of Food Allergy in Infantile Colic: Evidence and Clinical Management

et al. 2015

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Food allergies (FAs) are an increasing problem in Western countries, affecting up to 10% of young children. FAs are frequently associated with gastrointestinal manifestations. The role of FAs as a potential causative factor for infantile colic (IC) is still controversial. We report the most recent evidence on the pathogenesis, clinical and diagnostic aspects of FA-induced infantile colic (IC) and suggest a stepwise diagnostic approach. We selected articles on clinical and immunologic features, pathogenesis and management of FAs and IC from of 1981 to 2015. Original and review articles were identified through selective searches performed on PubMed, using the following terms: colic, infantile colic, food allergy and infantile colic, infantile colic treatment. The possible relationship between FAs and IC derives from the presence of dysmotility with visceral hypersensitivity and dysbiosis, demonstrated in both conditions, and the clinical response to dietary interventions. Unfortunately, the design of the studies, poor characterization of atopy and different dietary approaches limit the understanding of the importance of FAs in subjects with IC. The role of FAs in IC subjects without other symptoms of atopy remains controversial. However, where there is a suspicion of FAs, a short trial with an extensively hydrolyzed cow’s proteins formula or, if breast fed, with maternal elimination diet may be considered a reasonable option.

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Section: Evidencementioning

confidence: 99%

The Controversial Role of Food Allergy in Infantile Colic: Evidence and Clinical Management

et al. 2015

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“…Adverse immune responses to foods affect approximately 5% of young children and 3–4% of adults in Westernized countries and appear to have increased in prevalence . There are eight major sources of food allergens: egg, milk, peanut, tree nuts, fish, shellfish, wheat, and soy . Fish is widely appreciated by consumers because of its delicious taste and rich nutritional value.…”

Section: Introductionmentioning

confidence: 99%

Effect of tyrosinase‐catalyzed crosslinking on the structure and allergenicity of turbot parvalbumin mediated by caffeic acid

Tian

Ahmed

et al. 2019

J Sci Food Agric

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BACKGROUND Enzymatic treatment of allergenic protein can alter their functional properties under a mild reaction condition due to specificity of enzymes. Phenolic compounds act as mediators and enhance the crosslinking reactions. The study aimed to assess the changes in the structure and immunoglobulin G (IgG) binding capacity of turbot parvalbumin (PV) upon crosslinking with tyrosinase (Tyr) in the absence and presence of caffeic acid. RESULTS Sodium dodecyl sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE) analysis revealed the appearance of higher molecular weight bands (24, 36 kDa) in the crosslinked PV. The secondary structure of crosslinked PV became loosened and disordered. The results of intrinsic fluorescence and ultraviolet absorption spectral analyses, as well as surface hydrophobicity and free amino group analyses also revealed structural changes. As observed by western blot analysis, the intensity of the PV bands reduced upon Tyr treatment, indicating reduced binding of specific IgG to PV. Moreover, the indirect ELISA (enzyme‐linked immunosorbent assay) analysis confirmed that the IgG binding ability of crosslinked PV was reduced 34.94%. CONCLUSION Enzymatic treatment mitigated the allergenicity of fish PV, which was closely related to the alterations in the conformational structure. This treatment showed potential for developing hypoallergenic fish products under mild reaction conditions. © 2019 Society of Chemical Industry

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Effect of tyrosinase and caffeic acid crosslinking of turbot parvalbumin on the digestibility, and release of mediators and cytokines from activated RBL-2H3 cells

Ahmed

Liu

et al. 2019

Food Chemistry

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Diagnosing and Treating Food Allergy

Cited by 5 publications

References 59 publications

The Controversial Role of Food Allergy in Infantile Colic: Evidence and Clinical Management

The Controversial Role of Food Allergy in Infantile Colic: Evidence and Clinical Management

Effect of tyrosinase‐catalyzed crosslinking on the structure and allergenicity of turbot parvalbumin mediated by caffeic acid

Effect of tyrosinase and caffeic acid crosslinking of turbot parvalbumin on the digestibility, and release of mediators and cytokines from activated RBL-2H3 cells

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