Diagnosed Tuberculosis During the Follow-up of a Cohort of Human Immunodeficiency Virus-Infected Children in Abidjan, C??te d??Ivoire

Elenga, Narcisse; Ka, Kouakoussui; Bonard, Dominique; Franco, Patricia; Mf, Anaky; Ml, Wemin; Dick-Amon-Tanoh, F.; Raffi, François; Thouvenot, Vincent; Msellati, Philippe

doi:10.1097/01.inf.0000190008.91534.b7

Cited by 48 publications

(23 citation statements)

References 15 publications

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“…HIV-infected children, however, have a higher propensity for more extensive disease, more extrapulmonary disease and a higher rate of intracranial mass lesions [43,44 ,45]. Recurrent tuberculosis has been noted in 17 [43] and 10% [46] of patients, and this can be caused either by recurrence of the original infection or reinfection with a second strain of M. tuberculosis [46].…”

Section: Tuberculosis In Human Immunodeficiency Virus-infected Childrenmentioning

confidence: 98%

New concepts in childhood tuberculosis

Starke

2007

Current Opinion in Pediatrics

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Section: Tuberculosis In Human Immunodeficiency Virus-infected Childrenmentioning

confidence: 98%

New concepts in childhood tuberculosis

Starke

2007

Current Opinion in Pediatrics

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“…Adults with HIV disease have an increased incidence of pulmonary and extra pulmonary TB and also present with atypical pulmonary TB, less frequently being sputum smear-positive, and have a higher mortality rate [ 11,12]. A number of reports are available on the clinical manifestations and the outcome in small numbers of pediatric patients with HIV infection and TB [6,16,17,21]. In the most studies on HIV infection and TB in children from the developing countries, TB is not confirmed by culture.…”

Section: Introductionmentioning

confidence: 99%

Clinical Presentation, Treatment Outcome and Survival Among the HIV Infected Children with Culture Confirmed Tuberculosis

Kumar

Pandey²,

Kumari³

2007

CHR

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“…uman immunodeficiency virus (HIV) infection in children increases the risk of developing active tuberculosis (TB) (1)(2)(3)(4) and is associated with a 2-to 6-foldgreater risk of dying from TB (3,(5)(6)(7)(8). The poor TB treatment outcome in HIV-infected children is in part due to ongoing immunosuppression and delay in initiation of antiretroviral therapy (9).…”

mentioning

confidence: 99%

Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection

Antwi

Yang

Enimil

et al. 2017

Antimicrob Agents Chemother

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Although human immunodeficiency virus (HIV) coinfection is the most important risk factor for a poor antituberculosis (anti-TB) treatment response, its effect on the pharmacokinetics of the first-line drugs in children is understudied. This study examined the pharmacokinetics of the four first-line anti-TB drugs in children with TB with and without HIV coinfection. Ghanaian children with TB on isoniazid, rifampin, pyrazinamide, and ethambutol for at least 4 weeks had blood samples collected predose and at 1, 2, 4, and 8 hours postdose. Drug concentrations were determined by validated liquid chromatography-mass spectrometry methods and pharmacokinetic parameters calculated using noncompartmental analysis. The area under the concentration-time curve from 0 to 8 h (AUC 0 -8 ), maximum concentration (C max ), and apparent oral clearance divided by bioavailability (CL/F) for each drug were compared between children with and without HIV coinfection. Of 113 participants, 59 (52.2%) had HIV coinfection. The baseline characteristics were similar except that the coinfected patients were more likely to have lower weight-for-age and height-for-age Z scores (P Ͻ 0.05). Rifampin, pyrazinamide, and ethambutol median body weight-normalized CL/F values were significantly higher, whereas the plasma AUC 0 -8 values were lower, in the coinfected children than in those with TB alone. In the multivariate analysis, drug dose and HIV coinfection jointly influenced the apparent oral clearance and AUC 0 -8 for rifampin, pyrazinamide, and ethambutol. Isoniazid pharmacokinetics were not different by HIV coinfection status. HIV coinfection was associated with lower plasma exposure of three of the four first-line anti-TB drugs in children. Whether TB/HIV-coinfected children need higher dosages of rifampin, pyrazinamide, and ethambutol requires further investigation. (This study has been registered at ClinicalTrials.gov under identifier NCT01687504.)

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Diagnosed Tuberculosis During the Follow-up of a Cohort of Human Immunodeficiency Virus-Infected Children in Abidjan, C??te d??Ivoire

Abstract: The risk of tuberculosis among HIV-infected children in Côte d'Ivoire is strongly associated with the degree of immunodeficiency in HIV infection.

Cited by 48 publications

References 15 publications

New concepts in childhood tuberculosis

New concepts in childhood tuberculosis

Clinical Presentation, Treatment Outcome and Survival Among the HIV Infected Children with Culture Confirmed Tuberculosis

Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection

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