Diagnose und Therapie von Virusinfektionen bei Kindern und Jugendlichen mit neoplastischen Erkrankungen

Schuster, Friedhelm R.; Simon, A.; Laws, Hans‐Jürgen; Beutel, Karin; Groll, Andreas H.; Jäger, Gundula; Schuster, Verónica

doi:10.1055/s-2005-872519

Cited by 4 publications

(4 citation statements)

References 59 publications

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“…Viral infections in allogeneic hematopoietic stem cell transplant recipients are frequent complications 11 . Morbidity and letality of these infections are mainly influenced by the virus itself, recipient-and donor-specific factors like the immune status but also by graft source, immunosuppressive prophylaxis and therapy and occurrence of GvHD.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Refractory CMV-Infection Following Hematopoietic Stem Cell Transplantation with the Combination of Foscarnet and Leflunomide

et al. 2006

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Section: Introductionmentioning

confidence: 99%

Treatment of Refractory CMV-Infection Following Hematopoietic Stem Cell Transplantation with the Combination of Foscarnet and Leflunomide

et al. 2006

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“…Due to the nature of their disease and related therapy, children with cancer are at high risk of developing viral infections. 11 Likewise, it is logical to expect higher infectivity of COVID-19 in children with cancer. At our center, we found an even higher proportion of children having cancer as comorbidity.…”

Section: Discussionmentioning

confidence: 99%

Profile and Outcomes of COVID-19 Infection in Pediatric Patients with and without Cancer: A Case–Control Study

Sahi,

Kumar,

Gupta

et al. 2024

Indian J Med Paediatr Oncol

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Objectives Pediatric patients with cancer are considered a vulnerable population to the ill effects of coronavirus disease 2019 (COVID-19). We hereby studied the difference between clinical characteristics, lab parameters, and outcomes of COVID-19 among children suffering from cancer and those without cancer. We also analyzed risk factors for the occurrence of moderate-to-severe COVID-19 disease in pediatric cancer patients. Materials and Methods This retrospective case–control study was carried out using the medical record review method over 6 months in a tertiary-care center in India. All patients below 18 years of age, with reverse-transcriptase polymerase chain reaction (RTPCR) confirmed COVID-19, were screened for enrolment. Patients were split into two groups: Group A comprised of patients with cancer, while group B consisted of patients without any underlying comorbidity. Patients with other comorbidity except cancer and inadequately recorded case sheets were excluded. Details regarding demography, clinical features, investigations, treatment, and outcomes were recorded. Statistical Analysis Microsoft Excel and Statistical Package for the Social Sciences (SPSS) software, version 25 was used for data analysis. A p-value less than 0.05 was considered significant. Results Two-hundred-five pediatric inpatients with RTPCR-established COVID-19 infection were screened and final analyses were performed on 97 patients, of which 31 children were classified into group A and 66 into group B. Median age of enrolled children was 5 years with 58.8% males. The prevalence of cancer as a comorbidity in pediatric inpatients with COVID-19 was 15%. Fifty-five percent of cancer patients had hematological malignancies, while 45% had solid tumors. Fever (p = 0.001) and gastrointestinal manifestations (p = 0.0001) were significantly less common among pediatric cancer patients. Children with cancer had significantly more leukopenia (p = 0.003), neutropenia (p = 0.003), and lymphopenia (p = 0.005). The case fatality rate was higher in children with cancer (3.2%) as compared to noncancer patients (1.5%, p = 1.0). Few risk factors for moderate-to-severe COVID-19 among children with cancer included age less than 2 years (p = 0.06), undernutrition (p = 0.33), advanced stage of cancer (p = 0.49), and presence of coinfection (p = 0.35) Conclusion Cancer is a significant comorbidity among pediatric COVID-19 patients. While children with cancer have less severe COVID-19, their case fatality rate is higher than those without cancer. Younger age, undernutrition, advanced stage of cancer, and presence of coinfections may predispose to the development of moderate-to-severe COVID-19 among pediatric cancer patients.

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“…Due to the nature of their disease and related therapy, cancer patients are at high risk for developing various infections [1][2][3][4][5]. These infectious processes have a significant impact on morbidity and mortality, with higher standard mortality ratios compared to other causes of mortality [2,3].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and clinical characteristics of viral infections in hospitalized children and adolescents with cancer in Lebanon

et al. 2020

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Background Viral infections in children and adolescents with malignancy are commonly encountered and have a significant impact on morbidity and mortality. Studies and epidemiological data regarding viral infections in children with cancer in developing countries are lacking. This retrospective cohort study aims to assess the burden of viral infections in children and adolescents with cancer, by assessing prevalence, risk factors, as well as morbidity and mortality of common viruses over a period of 8 years. Methods and findings Medical records of cancer patients treated at the Children Cancer Center of Lebanon were reviewed and 155 participants under the age of 21 were identified with at least one documented viral infection during the period from July 2009 to November 2017. This subset included 136 participants with active malignancy and 19 participants with a history of cancer who underwent hematopoietic stem cell transplantation [HSCT] and were in remission; the latter group was analyzed separately. Information regarding participant characteristics, hospital course, and complications were obtained. Associations between viral infections and certain factors were assessed. In the cohort, 64% were male, 81% were Lebanese. In participants with active malignancy, 90% received chemotherapy in the 6 months preceding the viral infection episode, 11% received radiotherapy. 51% of participants were neutropenic at the time of viral detection, and 77% were lymphopenic. 17% experienced a bacterial coinfection, and 3 experienced a viral co-infection. Among 162 viral infection episodes,

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Diagnose und Therapie von Virusinfektionen bei Kindern und Jugendlichen mit neoplastischen Erkrankungen

Cited by 4 publications

References 59 publications

Treatment of Refractory CMV-Infection Following Hematopoietic Stem Cell Transplantation with the Combination of Foscarnet and Leflunomide

Treatment of Refractory CMV-Infection Following Hematopoietic Stem Cell Transplantation with the Combination of Foscarnet and Leflunomide

Profile and Outcomes of COVID-19 Infection in Pediatric Patients with and without Cancer: A Case–Control Study

Epidemiology and clinical characteristics of viral infections in hospitalized children and adolescents with cancer in Lebanon

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