Diagnose und Behandlung des Status epilepticus auf der Intensivstation

Müllges, Wolfgang

doi:10.1007/s00063-019-0581-8

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Seizure control can be achieved by administering benzodiazepines, such as lorazepam 2 mg or diazepam 5 mg, at 5-minute intervals. 5 If the seizure is reoccurring, it is recommended to administer a bolus of an antiepileptic drug (AED) together with benzodiazepines. One option is to administer phenytoin at a dose of 15-20 mg/kg for 25-50 minutes.…”

Section: Discussionmentioning

confidence: 99%

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Misoprostol-induced seizures following self-abortion: a rare, but repeated occurrence

Purushotmanan

2024

MYJA

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Misoprostol is a synthetic prostaglandin E1 (PGE) analogue used for medical termination of pregnancy, managing miscarriage, inducing labour, cervical ripening, and treating postpartum haemorrhage. Generally, it is safe and well-tolerated, with dose-dependent adverse effects such as nausea, vomiting, diarrhoea, abdominal pain, fever, and headache that usually resolve within a few days. However, seizures are a rare complication, occurring primarily in patients with a history of epilepsy or a predisposition to seizures and is associated with high doses and rapid administration. This case report highlights the repercussions of a misoprostol overdose used for pregnancy termination, leading to seizures induced by hyperthermia. The first patient required temporary invasive ventilation and resuscitation but recovered, whereas the second patient receiving a lower dose, exhibited milder symptoms. Both patients received psychosocial counselling prior to discharge.

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Section: Discussionmentioning

confidence: 99%

“…One option is to administer phenytoin at a dose of 15-20 mg/kg for 25-50 minutes. 5 In cases where phenytoin is contraindicated, IV levetiracetam of 40-60 mg/kg over 15 minutes is preferred.…”

Section: Discussionmentioning

confidence: 99%

Misoprostol-induced seizures following self-abortion: a rare, but repeated occurrence

Purushotmanan

2024

MYJA

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Intensivmedizin bei neurologischen Erkrankungen

Steigerwald¹,

Sitzer²,

Wilhelm³

2023

Praxis Der Intensivmedizin

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Status Epilepticus Diagnostic and Management Approach in Emergency Department

Alshehri¹,

Alotaibi²,

Alghanim³

et al. 2022

World Journal of Environmental Biosciences

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Status Epilepticus (SE) is a condition that arises from existing neurological disorders, including epilepsy syndromes. It refers to a state of incessant clinical and/or electrographic seizure activity, or recurrent seizure activity within 5 minutes during which the patient does not recover to a normal level of consciousness between seizures. It is also a medical emergency with a high complication rate. The Medline, PubMed, Embase, NCBI, and Cochrane databases were searched for studies of patients with SE. The incidence, etiology, and management options were analyzed. The reason why it is best to broadly classify SE as convulsive and nonconvulsive is that there are many types of seizures as there are types of SE. The complications likely to arise are both medical and neurological, as well as immediate and delayed. Neurological complications include recurrent status epilepticus and progression to chronic epilepsy. Patients with refractory status epilepticus are also likely to exhibit permanent neurological damage caused by abnormal and prolonged electrical activity in the brain, which induces hyper-metabolic activity. This is why it is recommended to begin treatment before the patient has even reached the hospital.

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Diagnose und Behandlung des Status epilepticus auf der Intensivstation

Cited by 3 publications

References 25 publications

Misoprostol-induced seizures following self-abortion: a rare, but repeated occurrence

Misoprostol-induced seizures following self-abortion: a rare, but repeated occurrence

Intensivmedizin bei neurologischen Erkrankungen

Status Epilepticus Diagnostic and Management Approach in Emergency Department

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