We establish the existence of a cutoff phenomenon for a natural analogue of the Brownian motion on free orthogonal quantum groups. We compute in particular the cutoff profile, whose type is different from the previously known examples and involves free Poisson laws and the semi-circle distribution. We prove convergence in total variation (and even in L p -norm for all p greater than 1) at times greater than the cutoff time and convergence in distribution for smaller times. We also study a similar process on quantum permutation groups, as well as the quantum random transposition walk. The latter yields in particular a quantum analogue of a recent result of the second-named author on random transpositions. 2020 Mathematics Subject Classification. 46L53, 60G10, 20G42. Key words and phrases. Cut-off phenomenon, Lévy process, quantum groups, random transpositions. 1 We do here (and sometimes in the sequel) a common abuse of notations, not writing the sequence indices.