Diacerein for osteoarthritis

Clinical Study on the Effects of Diacerein and Diacerein Combined with Chondroitin Sulfate on Canine Hip Osteoarthritis

“…But in clinical usage, there was no significant difference between 50 and 150 mg per day for pain score and clinical signs of OA [19] . The present study used 50 mg and 100 mg in the experimental design because previous human studies reported that the effective dose of diacerein was between 50-150 mg per day [13,19] . However, because the weights of all animals in this study were not more than 25 kg, we limited the dosage to 50 and 100 mg per day, while in human studies the highest dose was 150 mg for an average body weight of 60 kg.…”

“…Previous in vitro studies have reported that diacerein inhibits the secretion of IL-1β in a dose-dependent manner [9,19] . But in clinical usage, there was no significant difference between 50 and 150 mg per day for pain score and clinical signs of OA [19] .…”

“…In humans, the main side effects that have been reported are diarrhea/soft stools and dark urine [19] . Our study is the first to report on the side effects of diacerein in dogs.…”

Clinical Study on the Effects of Diacerein and Diacerein Combined with Chondroitin Sulfate on Canine Hip Osteoarthritis

“…But in clinical usage, there was no significant difference between 50 and 150 mg per day for pain score and clinical signs of OA [19] . The present study used 50 mg and 100 mg in the experimental design because previous human studies reported that the effective dose of diacerein was between 50-150 mg per day [13,19] . However, because the weights of all animals in this study were not more than 25 kg, we limited the dosage to 50 and 100 mg per day, while in human studies the highest dose was 150 mg for an average body weight of 60 kg.…”

“…Previous in vitro studies have reported that diacerein inhibits the secretion of IL-1β in a dose-dependent manner [9,19] . But in clinical usage, there was no significant difference between 50 and 150 mg per day for pain score and clinical signs of OA [19] .…”

“…In humans, the main side effects that have been reported are diarrhea/soft stools and dark urine [19] . Our study is the first to report on the side effects of diacerein in dogs.…”

Dealing with substantial heterogeneity in Cochrane reviews. Cross-sectional study

“…An additional review described the heterogeneity (I 2 = 71%, P = 0.06) but ignored it due to "lack of stability of the known tests" [ 29 ], which is not a valid reason for ignoring heterogeneity. In another review, the authors divided the analysis into subgroups because they had found heterogeneity, but although the consequence was that the chi-square test for heterogeneity was no longer significant due to loss of power, the I 2 actually increased , which the authors failed to comment on [ 30 ]. In yet another review, which was discussed above, the authors pooled two risk scores measured on different scales that varied by a factor of ten [ 11 ].…”

Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis

“…4 65 With these guidelines, the effect of the weight loss may be achieved within a few months, resulting in a clinical ES larger than most non-operative treatments systematically reviewed, applying meta-analyses, [66][67][68][69] and at least comparable to the possible effect of walking. 70 In the present meta-analysis, it is obvious that the strategies applied in the individual RCTs combine great diversity in both magnitude and intensity of the (weight-reducing) dietary strategies.…”

Clinical Study on the Effects of Diacerein and Diacerein Combined with Chondroitin Sulfate on Canine Hip Osteoarthritis

“…But in clinical usage, there was no significant difference between 50 and 150 mg per day for pain score and clinical signs of OA [19] . The present study used 50 mg and 100 mg in the experimental design because previous human studies reported that the effective dose of diacerein was between 50-150 mg per day [13,19] . However, because the weights of all animals in this study were not more than 25 kg, we limited the dosage to 50 and 100 mg per day, while in human studies the highest dose was 150 mg for an average body weight of 60 kg.…”

“…Previous in vitro studies have reported that diacerein inhibits the secretion of IL-1β in a dose-dependent manner [9,19] . But in clinical usage, there was no significant difference between 50 and 150 mg per day for pain score and clinical signs of OA [19] .…”

“…In humans, the main side effects that have been reported are diarrhea/soft stools and dark urine [19] . Our study is the first to report on the side effects of diacerein in dogs.…”

Dealing with substantial heterogeneity in Cochrane reviews. Cross-sectional study

“…An additional review described the heterogeneity (I 2 = 71%, P = 0.06) but ignored it due to "lack of stability of the known tests" [ 29 ], which is not a valid reason for ignoring heterogeneity. In another review, the authors divided the analysis into subgroups because they had found heterogeneity, but although the consequence was that the chi-square test for heterogeneity was no longer significant due to loss of power, the I 2 actually increased , which the authors failed to comment on [ 30 ]. In yet another review, which was discussed above, the authors pooled two risk scores measured on different scales that varied by a factor of ten [ 11 ].…”

Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis

“…4 65 With these guidelines, the effect of the weight loss may be achieved within a few months, resulting in a clinical ES larger than most non-operative treatments systematically reviewed, applying meta-analyses, [66][67][68][69] and at least comparable to the possible effect of walking. 70 In the present meta-analysis, it is obvious that the strategies applied in the individual RCTs combine great diversity in both magnitude and intensity of the (weight-reducing) dietary strategies.…”

Clinical Study on the Effects of Diacerein and Diacerein Combined with Chondroitin Sulfate on Canine Hip Osteoarthritis

“…But in clinical usage, there was no significant difference between 50 and 150 mg per day for pain score and clinical signs of OA [19] . The present study used 50 mg and 100 mg in the experimental design because previous human studies reported that the effective dose of diacerein was between 50-150 mg per day [13,19] . However, because the weights of all animals in this study were not more than 25 kg, we limited the dosage to 50 and 100 mg per day, while in human studies the highest dose was 150 mg for an average body weight of 60 kg.…”

“…Previous in vitro studies have reported that diacerein inhibits the secretion of IL-1β in a dose-dependent manner [9,19] . But in clinical usage, there was no significant difference between 50 and 150 mg per day for pain score and clinical signs of OA [19] .…”

“…In humans, the main side effects that have been reported are diarrhea/soft stools and dark urine [19] . Our study is the first to report on the side effects of diacerein in dogs.…”

Dealing with substantial heterogeneity in Cochrane reviews. Cross-sectional study

“…An additional review described the heterogeneity (I 2 = 71%, P = 0.06) but ignored it due to "lack of stability of the known tests" [ 29 ], which is not a valid reason for ignoring heterogeneity. In another review, the authors divided the analysis into subgroups because they had found heterogeneity, but although the consequence was that the chi-square test for heterogeneity was no longer significant due to loss of power, the I 2 actually increased , which the authors failed to comment on [ 30 ]. In yet another review, which was discussed above, the authors pooled two risk scores measured on different scales that varied by a factor of ten [ 11 ].…”

Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis

“…4 65 With these guidelines, the effect of the weight loss may be achieved within a few months, resulting in a clinical ES larger than most non-operative treatments systematically reviewed, applying meta-analyses, [66][67][68][69] and at least comparable to the possible effect of walking. 70 In the present meta-analysis, it is obvious that the strategies applied in the individual RCTs combine great diversity in both magnitude and intensity of the (weight-reducing) dietary strategies.…”