Diabetische Retinopathie und diabetisches Fußsyndrom bei Diabetikern in Kinshasa (Demokratische Republik Kongo)

Knappe, S.; Stoll, D.; Mt, Bambi; Kilangalanga, Janvier; Rf, Guthoff

doi:10.1055/s-0032-1315251

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Diabetic retinopathy patients are at high risk of DF. Knappe, Stoll, Bambi, Kilangalanga, and Guthoff () found there was a considerable discrepancy between partly extensive foot ulcerations and only mild to moderate diabetic retinopathy in most of the diabetic patients. Furthermore, Karam et al () found that an increased presence of retinopathy in patients was significant with an increased risk grade of DF.…”

Section: Introductionmentioning

confidence: 96%

An educational intervention on foot self‐care behaviour among diabetic retinopathy patients with visual disability and their primary caregivers

Guo

2019

Journal of Clinical Nursing

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Aims and objectives To assess the effectiveness of a 12‐week educational intervention on foot self‐care behaviour among diabetic retinopathy patients with visual disability and their primary caregivers in China. Background Diabetes with the coexistence of diabetic retinopathy and foot problems complicating diabetes not only represents a personal disaster, but also becomes a serious burden to public health in China. A foot self‐care educational intervention is both cost‐effective and feasible even in a health resource‐limited setting, which should be developed and evaluated. Design Quasi‐experimental. Methods From July–September 2017, we enrolled 80 eligible hospitalised diabetic retinopathy patients and their primary caregivers by convenient sampling method in a first‐class comprehensive hospital in Nantong, in China. Before and after the educational intervention that is in accordance with the TREND statement (for details, see the “Supplementary File 1”), researchers and subjects filled out the self‐designed questionnaire on foot problems complicating diabetes and the Diabetic Foot Self‐care Behavior Scale, respectively. Results Scores of foot self‐care behaviour among the subjects significantly improved from 54.19 ± 8.01–75.85 ± 5.04. The number of patients with fasting blood glucoses <7.0 mmol/L improved from 43 (53.75%)–80 (100%). The results of incidence of foot problems complicating diabetes were not statistically significant. The complete execution of each item in Diabetic Foot Self‐care Behavior Scale of subjects was apparently higher. Conclusions This educational intervention can facilitate positive foot self‐care behaviours among the diabetic retinopathy patients with visual disability and their primary caregivers in China. Relevance to clinical practice. This study adds to the evidence of the effectiveness of an educational intervention to foster positive foot self‐care behaviours. This educational intervention appears to be prospective in promoting diabetic home‐based self‐management in China, and the delivery method of the intervention may be applied to other chronic diseases.

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Section: Introductionmentioning

confidence: 96%

An educational intervention on foot self‐care behaviour among diabetic retinopathy patients with visual disability and their primary caregivers

Guo

2019

Journal of Clinical Nursing

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Diabetic Foot Syndrome and Corneal Subbasal Nerve Plexus Changes in Congolese Patients with Type 2 Diabetes

et al. 2015

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BackgroundTo study the severity of diabetic neuropathy, diabetic retinopathy and grades of diabetic foot syndrome for correlations with corneal subbasal nerve plexus (SBP) changes in Congolese patients with type 2 diabetes.Methodology/Principal FindingsTwenty-eight type 2 diabetes patients with diabetes-related foot ulceration were recruited in a diabetic care unit in Kinshasa, Democratic Republic of Congo. Corneal SBP was investigated by confocal laser-scanning microscopy to analyse nerve fibre density (NFD) [µm/ µm²], number of branches [n] and number of connectivity points [n]. Foot ulceration was graded using the Wagner ulcer classification. Corneal sensitivity (Cochet-Bonnet), Neuropathy Symptom Score (NSS), Neuropathy Disability Score (NDS), ankle-brachial index (ABI) and ophthalmological status were evaluated. Foot ulceration was ranked as mild (Wagner 0-1: 13 patients/46.4%), moderate (Wagner 2-3: 10 patients/35.7%) and severe (Wagner 4-5: 5 patients/17.9%). The correlation between Wagner Score and NFD (p=0.017, r = - 0,454), NDS and NFD (p=0,039, r = - 0.400) as well as Wagner Score and HbA1c (p=0,007, r = - 0.477) was stated. Significant differences in confocal SBP parameters were observed between Wagner 0-1 and Wagner 4 5 (number of branches (p=0.012), number of connectivity points (p=0.001), nerve fibre density (p=0.033)) and ABI (p=0.030), and between Wagner 2-3 and Wagner 4-5 (number of branches (p=0.003), number of connectivity points (p=0.005) and nerve fibre density (p=0.014)). Differences in NDS (p=0.001) and corneal sensation (p=0.032) were significant between Wagner 0-1 and Wagner 2-3. Patients with diabetic retinopathy had significantly longer diabetes duration (p=0.03) and higher NDS (p=0.01), but showed no differences in SBP morphology or corneal sensation.Conclusions/SignificanceWhile confirming the diabetic aetiology of foot ulceration due to medial arterial calcification, this study indicates that the grade of diabetic foot syndrome correlates with corneal SBP changes and corneal sensation in patients in sub-Saharan Africa.

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Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions

Bi¹,

Song²,

Shang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.We investigated the effect of atorvastatin on vascular endothelial growth inhibitor (VEGI) expression in rats with diabetic retinopathy. Wistar rats were divided into a blank group and diabetic model group, which was further randomly divided into treatment and control groups. Rats in the treatment group received 10 mg/kg atorvastatin daily, while rats in the blank and control groups received normal saline. Rats were randomly euthanized at 3 or 6 months. Immunohistochemical staining was used to determine changes in VEGI and vascular endothelial growth factor, interleukin-4, and tumor necrosis factor α levels in rats with diabetic retinopathy. Survival rate in the treatment group was 84% (63/75) after 6 months, which was significantly higher than that in the control group (P < 0.05); rats in the control group showed the lowest survival rate. Survival in the treatment group was higher than that in the control group but not significant compared with the blank group after 3 months. VEGI, vascular endothelial growth factor, tumor necrosis factor α, and interluekin-4 expression was lower than that in the control group, but higher than the blank group after 3 months. The (2015) expression of each factor decreased to the blank group level in the treatment group and was significantly lower than that in the control group after 6 months (P < 0.05). Expression in control and blank groups was similar at 3 and 6 months. Atorvastatin can inhibit VEGI and vascular endothelial growth factor expression to protect rats from diabetic retinopathy.

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Diabetische Retinopathie und diabetisches Fußsyndrom bei Diabetikern in Kinshasa (Demokratische Republik Kongo)

Cited by 3 publications

References 30 publications

An educational intervention on foot self‐care behaviour among diabetic retinopathy patients with visual disability and their primary caregivers

An educational intervention on foot self‐care behaviour among diabetic retinopathy patients with visual disability and their primary caregivers

Diabetic Foot Syndrome and Corneal Subbasal Nerve Plexus Changes in Congolese Patients with Type 2 Diabetes

Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions

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