Diabetic Wound Healing and Limb Salvage in an Outpatient Wound Care Program

Keyser, John

doi:10.1097/00007611-199303000-00013

Cited by 22 publications

(13 citation statements)

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“…[2][3][4] The effectiveness of patient education on wound care can be shown by various studies on improving health outcomes such as reducing hospital admissions, improving wound healing time, reducing fi nancial costs and home visits, preventing wounds from deteriorating, and reducing wound complications such as infection and lower limb amputation. [2][3][4] The effectiveness of patient education on wound care can be shown by various studies on improving health outcomes such as reducing hospital admissions, improving wound healing time, reducing fi nancial costs and home visits, preventing wounds from deteriorating, and reducing wound complications such as infection and lower limb amputation.…”

Section: Instrumentmentioning

confidence: 99%

The Effect of Patient Education With Telephone Follow-up on Wound Healing in Adult Patients With Clean Wounds

Chan

Lai

2014

Journal of Wound, Ostomy &Amp; Continence Nursing

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Section: Instrumentmentioning

confidence: 99%

The Effect of Patient Education With Telephone Follow-up on Wound Healing in Adult Patients With Clean Wounds

Chan

Lai

2014

Journal of Wound, Ostomy &Amp; Continence Nursing

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“…offloading of pressure on the area, frequent debridement, dressings and management of infection 8,9 . Surgeons will be involved in more radical debridements.…”

Section: Clinical Problem Of Diabetic Foot Ulcersmentioning

confidence: 99%

“…It is a member of the FGF family 60 (and as such is now also called FGF7 61 ); it is produced only by fibroblasts. There is increased expression of KGF during re-epithelialization of normal skin, and it induces the proliferation and migration of keratinocytes 8,59 . It may constitute the dermal/epidermal signal stimulating re-epithelialization of a wound, and may be important in diabetic foot ulcers where re-epithelialization of a healing wound can be non-existent.…”

Section: Keratinocyte Growth Factormentioning

confidence: 99%

Growth factors in the treatment of diabetic foot ulcers

Bennett

Griffiths

Schor

et al. 2003

British Journal of Surgery

283

208

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There has been a generally disappointing clinical outcome from growth factor trials, although topical platelet-derived growth factor has shown significant benefit and should be considered in non-healing, well perfused ulcers after failure of conventional wound care. The modulatory role of the extracellular matrix in the cellular response to growth factors and data from regenerative-type fetal wound healing are further areas of interest. The chemical induction of microvessel formation may become a future therapeutic option.

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“…in vivo prospective controlled studies as well as retrospective and cost effectiveness studies documenting the effects of this therapy have been published [20-23]. Its biocompatible and biodegradable properties prevent the PRP from inducing foreign body reactions, tissue necrosis, or extensive fibrosis [24-27].…”

Section: Discussionmentioning

confidence: 99%

Favorable Vocal Fold Wound Healing Induced by Platelet-Rich Plasma Injection

Woo

Jeong

Kim

et al. 2014

Clin Exp Otorhinolaryngol

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ObjectivesTo introduce a new injection material for vocal fold diseases, which could be readily translated to clinical practice, we investigated the effectiveness of platelet-rich plasma (PRP) injection on the injured vocal fold in terms of histological recovery.MethodsBlood samples were drawn from New Zealand White rabbits and PRP was isolated through centrifugation and separation of the samples. Using a CO2 laser, we made a linear wound in the 24 vocal fold sides of 12 rabbits and injected each wound with PRP on one vocal fold side and normal saline (NS) on the other. Morphologic analyses were conducted at 2, 4, and 12 weeks after injection, and inflammatory response, collagen deposit, and changes in growth factors were assessed using H&E and masson trichrome (MT) staining and western blot assay.ResultsPRP was prepared in approximately 40 minutes. The mean platelet concentration was 1,315,000 platelets/mm3. In morphological analyses, decreased granulation was observed in the PRP-injected vocal folds (P<0.05). However, the irregular surface and atrophic change were not difference. Histological findings revealed significant inflammation and collagen deposition in NS-injected vocal folds, whereas the PRP-injected vocal folds exhibited less (P<0.05). However, the inflammatory reaction and fibrosis were not difference. In western blot assay, increased amounts of growth factors were observed in PRP-injected vocal folds.ConclusionInjection of injured rabbit vocal folds with PRP led to improved wound healing and fewer signs of scarring as demonstrated by decreased inflammation and collagen deposition. The increased vocal fold regeneration may be due to the growth factors associated with PRP.

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Diabetic Wound Healing and Limb Salvage in an Outpatient Wound Care Program

Cited by 22 publications

References 0 publications

The Effect of Patient Education With Telephone Follow-up on Wound Healing in Adult Patients With Clean Wounds

The Effect of Patient Education With Telephone Follow-up on Wound Healing in Adult Patients With Clean Wounds

Growth factors in the treatment of diabetic foot ulcers

Favorable Vocal Fold Wound Healing Induced by Platelet-Rich Plasma Injection

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