Diabetic visceral neuropathy of gastroparesis: Gastric mucosal innervation and clinical significance

Tseng, Ping‐Huei; Chao, Chi‐Chao; Cheng, Ya-Yin; Chen, Chieh‐Chang; Yang, Ping‐Hao; Yang, Wen-Chieh; Wu, Sheng; Wu, Yen-Wen; Cheng, Mei‐Fang; Yang, Wei–Shiung; Wu, Ming–Shiang; Hsieh, Sung‐Tsang

doi:10.1111/ene.15333

Cited by 8 publications

(5 citation statements)

References 58 publications

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“…Although HbA1c levels are associated with the glycemic control status of diabetic patients, we were unable to determine the causal relationship between blood sugar levels (including overall blood sugar levels, fasting blood sugar levels and 2-hour blood sugar levels) and gastric cancer. Some studies have shown a negative correlation between gastric mucosal innervation density (MID) with fasting blood sugar levels and glycated hemoglobin levels (33), besides, vagotomy inhibits gastric cancer development by inhibiting tumor cell proliferation through suppressing WNT signaling pathway (34,35), which may help explain our results.…”

Section: The Association Between T2dm With Gastric and Colorectal Cancersupporting

confidence: 55%

T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis

An,

Zhang,

Sha

et al. 2024

Front. Oncol.

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IntroductionType 2 diabetes mellitus (T2DM) was associated with digestive system tumors. We analyzed publicly available data from GWAS studies using Mendelian randomization methods to clarify its causal relationship and mechanisms. Five common digestive system tumors and four diabetes-related phenotypes were included.MethodsInverse variance weighted method was the main analytical method. Meta-analysis was used to summarize results of multiple data sources. Horizontal pleiotropy was tested using Egger-intercept method and validated by MRPRESSO method. Heterogeneity and sensitivity analysis were conducted by Cochran’s Q test and leave-one-out method, respectively.ResultsT2DM is associated with a reduced risk of esophageal (OR: 0.77, 95% CI: 0.71 to 0.83, P< 0.001), gastric (OR: 0.87, 95% CI: 0.84 to 0.90, P< 0.001) and colorectal cancer (OR: 0.88, 95% CI: 0.85 to 0.91, P< 0.001) and hepatocellular carcinoma (OR: 0.92, 95% CI: 0.86 to 0.97, P = 0.005) and an increased risk of pancreatic cancer (OR: 1.92, 95% CI: 1.47 to 2.50, P< 0.001) in East Asian population. T2DM causes decreased fasting insulin levels (OR = 0.966, 95% CI: 0.95 to 0.98, P< 0.001) and increased glycated hemoglobin levels (OR=1.41, 95% CI: 1.39 to 1.44, P<0.001). Elevated fasting insulin levels increase the risk of esophageal cancer (OR = 10.35, 95% CI: 1.10 to 97.25, P = 0.041), while increased glycated hemoglobin levels increase pancreatic cancer risk (OR=2.33, 95% CI: 1.37 to 3.97, P=0.002) but decrease gastric cancer risk (OR=0.801, 95% CI: 0.65 to 0.99, P=0.044).ConclusionT2DM is associated with a reduced risk of esophageal, gastric and colorectal cancer and hepatocellular carcinoma in East Asian populations. The causal relationships between T2DM with esophageal and gastric cancer are partially mediated by decreased fasting insulin and increased glycated hemoglobin levels, respectively. T2DM indirectly increases the risk of pancreatic cancer by increasing glycated hemoglobin levels.

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Section: The Association Between T2dm With Gastric and Colorectal Cancersupporting

confidence: 55%

T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis

An,

Zhang,

Sha

et al. 2024

Front. Oncol.

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“…A total of 3,200,177 participants with DM were included in the meta-analysis, with 50,833 of them having gastroparesis. Because the diagnostic criteria for DGP have not been standardised and its prevalence varies significantly in national and international reports, the main modalities currently used to diagnose DGP are the Gastroparesis Cardinal Symptom Index (GCSI) 16 and GES 17 . The GCSI scale total score is a more reliable tool for assessing early gastroparesis, with a significant relationship found between the severity of symptoms assessed by the clinician and the GCSI total score 18 .…”

Section: Resultsmentioning

confidence: 99%

Prevalence of gastroparesis in diabetic patients: a systematic review and meta-analysis

Li,

Wang,

Long

et al. 2023

Sci Rep

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Although there was no significant heterogeneity in the meta-publication, sensitivity analyses revealed significant heterogeneity. Overall, the prevalence was higher in women (N = 6, R = 4.6%, 95% CI 3.1%, 6.0%, and I2 = 99.8%) than in men (N = 6, R = 3.4%, 95% CI 2.0%, 4.7%, and I2 = 99.6the %); prevalence of type 2 diabetes (N = 9, R = 12.5%, 95% CI 7.7%, 17.3%, and I2 = 95.4%) was higher than type 1 diabetes (N = 7, R = 8.3%, 95% CI 6.4%, 10.2%, and I2 = 93.6%); the prevalence of DGP was slightly lower in DM patients aged over 60 years (N = 6, R = 5.5%, 95% CI 3.3%, 7.7%, and I2 = 99.9%) compared to patients under 60 years of age (N = 12, R = 15.8%, 95% CI 11 15.8%, 95% CI 11.4%, 20.2%, and I2 = 88.3%). In conclusion, our findings indicate that the combined estimated prevalence of gastroparesis in diabetic patients is 9.3%. However, the sensitivity of the results is high, the robustness is low, and there are significant bias factors. The subgroup analysis revealed that the prevalence of DM-DGP is associated with factors such as gender, diabetes staging, age, and study method.

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Section: The Association Between T2dm With Gastric and Colorectal Cancersupporting

confidence: 55%

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Diabetic visceral neuropathy of gastroparesis: Gastric mucosal innervation and clinical significance

Cited by 8 publications

References 58 publications

T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis

T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis

Prevalence of gastroparesis in diabetic patients: a systematic review and meta-analysis

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